Rpe65 (retinoid isomerohydrolase RPE65) - Rat Genome Database

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Gene: Rpe65 (retinoid isomerohydrolase RPE65) Rattus norvegicus
Analyze
Symbol: Rpe65
Name: retinoid isomerohydrolase RPE65
RGD ID: 621396
Description: Enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Involved in several processes, including circadian rhythm; neural retina development; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65); PARTICIPATES IN retinoid cycle metabolic pathway; altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium 65; retinal pigment epithelium 65-like; retinal pigment epithelium, 65 kDa; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65; retinoid isomerohydrolase; retinol isomerase; RPE65, retinoid isomerohydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22248,766,497 - 248,798,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2248,766,612 - 248,798,403 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2256,482,408 - 256,514,178 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02254,375,936 - 254,407,703 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02249,342,889 - 249,374,020 (+)NCBIRnor_WKY
Rnor_6.02266,141,581 - 266,169,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2266,141,581 - 266,169,197 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02284,774,159 - 284,804,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.12257,860,998 - 257,893,921 (+)NCBI
Celera2240,512,281 - 240,537,640 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased light damage susceptibility at night does not correlate with RPE65 levels and rhodopsin regeneration in rats. Beatrice J, etal., Exp Eye Res. 2003 Jun;76(6):695-700.
2. A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement. Bowne SJ, etal., Eur J Hum Genet. 2011 Oct;19(10):1074-81. doi: 10.1038/ejhg.2011.86. Epub 2011 Jun 8.
3. The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium. Bridges CD and Alvarez RA, Science. 1987 Jun 26;236(4809):1678-80.
4. Distribution of retinol isomerase in vertebrate eyes and its emergence during retinal development. Bridges CD Vision Res. 1989;29(12):1711-7.
5. RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. Chen Y, etal., Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1177-84.
6. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Expression of RPE65, a putative receptor for plasma retinol-binding protein, in nonmelanocytic skin tumours. Hinterhuber G, etal., Br J Dermatol. 2005 Oct;153(4):785-9.
10. Localizations of visual cycle components in retinal pigment epithelium. Huang J, etal., Mol Vis. 2009;15:223-34. Epub 2009 Jan 26.
11. Retinal gene expression and visually evoked behavior in diabetic long evans rats. Kirwin SJ, etal., Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7654-63. doi: 10.1167/iovs.10-6609.
12. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, etal., Biochim Biophys Acta. 2012 Jan;1821(1):137-51. Epub 2011 Apr 5.
13. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. Mandal MN, etal., J Biol Chem. 2011 Sep 16;286(37):32491-501. Epub 2011 Jul 24.
14. Rat messenger RNA for the retinal pigment epithelium-specific protein RPE65 gradually accumulates in two weeks from late embryonic days. Manes G, etal., FEBS Lett 1998 Feb 20;423(2):133-7.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Experimental autoimmune uveitis induced by immunization with retinal pigment epithelium-specific 65-kDa protein peptides. Nakamura H, etal., Curr Eye Res. 2005 Aug;30(8):673-80.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinal. Samardzija M, etal., Hum Mol Genet. 2008 Jan 15;17(2):281-92. Epub 2007 Oct 12.
25. Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats. Tanito M, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1864-72.
26. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Wang NK, etal., Transplantation. 2010 Apr 27;89(8):911-9. doi: 10.1097/TP.0b013e3181d45a61.
27. Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis. Woodruff ML, etal., Nat Genet 2003 Oct;35(2):158-64. Epub 2003 Sep 21.
28. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
29. The Rpe65 rd12 allele exerts a semidominant negative effect on vision in mice. Wright CB, etal., Invest Ophthalmol Vis Sci. 2014 Apr 17;55(4):2500-15. doi: 10.1167/iovs.13-13574.
Additional References at PubMed
PMID:11897783   PMID:15557452   PMID:16150724   PMID:17251447   PMID:17272282   PMID:18195010   PMID:21052544   PMID:25112876   PMID:28500718   PMID:28874556   PMID:29569173   PMID:29659842  


Genomics

Comparative Map Data
Rpe65
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22248,766,497 - 248,798,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2248,766,612 - 248,798,403 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2256,482,408 - 256,514,178 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02254,375,936 - 254,407,703 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02249,342,889 - 249,374,020 (+)NCBIRnor_WKY
Rnor_6.02266,141,581 - 266,169,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2266,141,581 - 266,169,197 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02284,774,159 - 284,804,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.12257,860,998 - 257,893,921 (+)NCBI
Celera2240,512,281 - 240,537,640 (+)NCBICelera
Cytogenetic Map2q45NCBI
RPE65
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,428,822 - 68,449,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl168,428,822 - 68,449,954 (-)EnsemblGRCh38hg38GRCh38
GRCh37168,894,505 - 68,915,637 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,667,095 - 68,688,230 (-)NCBINCBI36Build 36hg18NCBI36
Build 34168,606,465 - 68,627,663NCBI
Celera167,184,748 - 67,205,854 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef167,004,313 - 67,025,452 (-)NCBIHuRef
CHM1_1169,009,866 - 69,031,001 (-)NCBICHM1_1
T2T-CHM13v2.0168,306,207 - 68,327,339 (-)NCBIT2T-CHM13v2.0
Rpe65
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393159,304,712 - 159,330,944 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3159,304,812 - 159,330,958 (+)EnsemblGRCm39 Ensembl
GRCm383159,599,075 - 159,625,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3159,599,175 - 159,625,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv373159,262,145 - 159,288,271 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363159,534,526 - 159,560,092 (+)NCBIMGSCv36mm8
Celera3166,038,618 - 166,064,587 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map382.52NCBI
Rpe65
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,183,937 - 23,208,282 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542323,184,326 - 23,208,206 (+)NCBIChiLan1.0ChiLan1.0
RPE65
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1169,623,775 - 69,644,894 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,623,775 - 69,644,904 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0167,666,784 - 67,687,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RPE65
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1676,887,399 - 76,911,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl676,887,399 - 76,911,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha679,498,666 - 79,521,615 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0677,481,101 - 77,504,927 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,481,101 - 77,504,925 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,031,835 - 77,055,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0676,935,191 - 76,959,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,422,281 - 77,446,314 (+)NCBIUU_Cfam_GSD_1.0
Rpe65
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505881,055,133 - 81,142,276 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365913,347,346 - 3,368,062 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPE65
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,206,078 - 144,229,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16144,206,078 - 144,229,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26133,491,901 - 133,514,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPE65
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12064,662,777 - 64,684,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2064,664,358 - 64,683,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603352,929,980 - 52,950,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rpe65
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,302,453 - 27,319,203 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474227,302,222 - 27,319,549 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87hepatic copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000051951
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 1 11 24 8 17 8 3 3 22 8 10 9 3
Below cutoff 1 10 6 6 1 6 5 7 10 2 9 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051951   ⟹   ENSRNOP00000040609
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2248,767,519 - 248,798,403 (+)Ensembl
Rnor_6.0 Ensembl2266,141,581 - 266,169,197 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078187   ⟹   ENSRNOP00000069757
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2248,766,612 - 248,798,403 (+)Ensembl
Rnor_6.0 Ensembl2266,141,581 - 266,169,197 (+)Ensembl
RefSeq Acc Id: NM_053562   ⟹   NP_446014
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22248,766,612 - 248,798,403 (+)NCBI
Rnor_6.02266,141,581 - 266,169,197 (+)NCBI
Rnor_5.02284,774,159 - 284,804,254 (+)NCBI
Celera2240,512,281 - 240,537,640 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103279   ⟹   XP_038959207
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22248,766,498 - 248,797,975 (+)NCBI
RefSeq Acc Id: XM_039103280   ⟹   XP_038959208
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22248,766,497 - 248,797,975 (+)NCBI
RefSeq Acc Id: XM_039103281   ⟹   XP_038959209
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22248,766,498 - 248,797,975 (+)NCBI
RefSeq Acc Id: XM_039103282   ⟹   XP_038959210
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22248,766,498 - 248,797,975 (+)NCBI
RefSeq Acc Id: XM_039103283   ⟹   XP_038959211
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22248,766,500 - 248,789,699 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446014   ⟸   NM_053562
- UniProtKB: F1M8Q2 (UniProtKB/Swiss-Prot),   O70276 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040609   ⟸   ENSRNOT00000051951
RefSeq Acc Id: ENSRNOP00000069757   ⟸   ENSRNOT00000078187
RefSeq Acc Id: XP_038959208   ⟸   XM_039103280
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038959207   ⟸   XM_039103279
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959209   ⟸   XM_039103281
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038959210   ⟸   XM_039103282
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038959211   ⟸   XM_039103283
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70276-F1-model_v2 AlphaFold O70276 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621396 AgrOrtholog
BioCyc Gene G2FUF-50686 BioCyc
BioCyc Pathway PWY-6861 [the visual cycle I (vertebrates)] BioCyc
Ensembl Genes ENSRNOG00000009582 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040609.4 UniProtKB/TrEMBL
  ENSRNOP00000069757 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051951.4 UniProtKB/TrEMBL
  ENSRNOT00000078187 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Carotenoid_Oase UniProtKB/Swiss-Prot
KEGG Report rno:89826 UniProtKB/Swiss-Prot
NCBI Gene 89826 ENTREZGENE
PANTHER PTHR10543 UniProtKB/Swiss-Prot
Pfam RPE65 UniProtKB/Swiss-Prot
PhenoGen Rpe65 PhenoGen
UniProt A0A8L2QKB1_RAT UniProtKB/TrEMBL
  F1M8Q2 ENTREZGENE
  O70276 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1M8Q2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Rpe65  retinoid isomerohydrolase RPE65  Rpe65  RPE65, retinoid isomerohydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-13 Rpe65  RPE65, retinoid isomerohydrolase  Rpe65  retinal pigment epithelium-specific protein 65  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-04-02 Rpe65  retinal pigment epithelium-specific protein 65  Rpe65  retinal pigment epithelium 65  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rpe65  retinal pigment epithelium 65    retinal pigment epithelium, 65 kDa  Name updated 1299863 APPROVED
2002-08-07 Rpe65  retinal pigment epithelium, 65 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL