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Term:
Parent Terms Term With Siblings Child Terms
1-hydroxy-2-naphthoate 1,2-dioxygenase activity 
2,3-dihydroxy-p-cumate dioxygenase activity 
2,3-dihydroxybenzoate 2,3-dioxygenase activity 
2,3-dihydroxybenzoate 3,4-dioxygenase activity 
2,3-dihydroxybiphenyl 1,2-dioxygenase activity 
2,3-dihydroxyindole 2,3-dioxygenase activity 
2,4'-dihydroxyacetophenone dioxygenase activity 
2,5-dihydroxypyridine 5,6-dioxygenase activity 
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity 
3,4-dihydroxyphenylacetate 2,3-dioxygenase activity 
3-carboxyethylcatechol 2,3-dioxygenase activity 
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity 
3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity 
3-hydroxyanthranilate 3,4-dioxygenase activity  
4-hydroxycatechol 1,2-dioxygenase activity 
4-hydroxymandelate synthase activity  
4-hydroxyphenylpyruvate dioxygenase activity  
5,6-dimethylbenzimidazole synthase activity 
7,8-dihydroxykynurenate 8,8a-dioxygenase activity 
9-cis-10'-apo-beta-carotenal cleavage oxygenase activity 
9-cis-beta-carotene 9',10'-cleavage oxygenase activity 
acetylacetone-cleaving enzyme activity 
acireductone dioxygenase (Ni2+-requiring) activity  
acireductone dioxygenase [iron(II)-requiring] activity  
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity 
all-trans-beta-apo-10'-carotenal cleavage oxygenase activity 
arachidonate 12(R)-lipoxygenase activity  
arachidonate 12(S)-lipoxygenase activity  
Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
arachidonate 15-lipoxygenase activity  
arachidonate 5-lipoxygenase activity  
arachidonate 8(R)-lipoxygenase activity  
arachidonate 8(S)-lipoxygenase activity  
beta,beta-carotene-9',10'-cleaving oxygenase activity  
beta-carotene 15,15'-dioxygenase activity  
biphenyl-2,3-diol 1,2-dioxygenase activity 
caffeate 3,4-dioxygenase activity 
carotenoid dioxygenase activity +   
catechol 1,2-dioxygenase activity 
catechol 2,3-dioxygenase activity 
chloridazon-catechol dioxygenase activity 
chlorite O2-lyase activity 
cysteamine dioxygenase activity  
cysteine dioxygenase activity  
fatty acid alpha-dioxygenase activity 
gallate dioxygenase activity 
gentisate 1,2-dioxygenase activity 
homogentisate 1,2-dioxygenase activity  
hydroxyquinol 1,2-dioxygenase activity 
indole 2,3-dioxygenase activity 
indoleamine 2,3-dioxygenase activity  
lignostilbene alpha beta-dioxygenase activity 
linoleate 11-lipoxygenase activity 
linoleate 13S-lipoxygenase activity  
linoleate 8R-lipoxygenase activity 
linoleate 9S-lipoxygenase activity  
linolenate 9R-lipoxygenase activity 
p-cumate 2,3-dioxygenase activity 
protocatechuate 3,4-dioxygenase activity 
protocatechuate 4,5-dioxygenase activity 
pyrogallol 1,2-oxygenase activity 
quercetin 2,3-dioxygenase activity  
stizolobate synthase activity 
stizolobinate synthase activity 
sulfur dioxygenase activity  
sulfur oxygenase/reductase activity 
tryptophan 2,3-dioxygenase activity  
violaxanthin oxygenase activity 

Synonyms
Broad Synonyms: leukotriene A4 synthase
Related Synonyms: 12-lipoxygenase activity ;   12Delta-lipoxygenase activity ;   12S-lipoxygenase activity ;   C-12 lipoxygenase activity ;   LTA4 synthase activity ;   arachidonate:oxygen 12-oxidoreductase activity ;   delta12-lipoxygenase activity
Xrefs: EC:1.13.11.31 ;   KEGG_REACTION:R01596 ;   MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN ;   RHEA:10428 ;   Reactome:R-HSA-2161948 "Arachidonate is converted to 12-oxoETE by ALOX12" ;   Reactome:R-HSA-2161950 "Arachidonate is oxidised to 12R-HpETE by ALOX12B" ;   Reactome:R-HSA-2161964 "Arachidonate is oxidised to 12S-HpETE by ALOX12/15" ;   reactome:R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA" ;   reactome:R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6" ;   reactome:R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3"
Definition Sources: EC:1.13.11.31, RHEA:10428

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