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ONTOLOGY REPORT - ANNOTATIONS

Term:phospholipase C-activating G protein-coupled receptor signaling pathway
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Accession:GO:0007200 term browser browse the term
Definition:A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.
Synonyms:exact_synonym: G protein signaling, coupled to IP3 second messenger (phospholipase C activating);   G protein signalling, coupled to IP3 second messenger (phospholipase C activating);   G-protein coupled receptor signaling pathway coupled to IP3 second messenger;   PLC-activating GPCR signaling pathway;   protein kinase C-activating G protein-coupled receptor signaling pathway
 related_synonym: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

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phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24367707) MGI
Ensembl		 PMID:24367707 GO_REF:0000107 NCBI chrNW_004936481:9,823,790...9,847,291
Ensembl chrNW_004936481:9,824,392...9,847,104 		JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:9,653,233...9,683,258
Ensembl chrNW_004936475:9,671,868...9,681,988 		JBrowse link
G Adora2a adenosine A2a receptor ISO in PC12 cells, PKCs epsilon and zeta activated after short-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9590558) Ensembl
TreeGrafter
MGI		 PMID:9590558 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936757:149,366...237,710
Ensembl chrNW_004936757:150,496...237,710 		JBrowse link
G Adra1b adrenoceptor alpha 1B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936515:3,523,799...3,572,467
Ensembl chrNW_004936515:3,523,797...3,572,596 		JBrowse link
G Adra1d adrenoceptor alpha 1D involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936485:14,514,395...14,538,389
Ensembl chrNW_004936485:14,515,494...14,537,631 		JBrowse link
G Agtr1 angiotensin II receptor type 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:11906170 GO_REF:0000107 RGD:70819 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Ano1 anoctamin 1 involved_in ISO (PMID:22634729) UniProt PMID:22634729 NCBI chrNW_004936599:647,230...726,371
Ensembl chrNW_004936599:648,659...719,310 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:6,415,544...6,423,863
Ensembl chrNW_004936557:6,415,547...6,424,711 		JBrowse link
G C3ar1 complement C3a receptor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936892:347,547...355,143
Ensembl chrNW_004936892:347,842...349,296 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936664:1,026,216...1,033,438
Ensembl chrNW_004936664:1,032,304...1,033,374 		JBrowse link
G C5ar2 complement C5a receptor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936664:1,047,997...1,050,612
Ensembl chrNW_004936664:1,047,997...1,049,016 		JBrowse link
G Calca calcitonin related polypeptide alpha involved_in ISO (PMID:9685362) UniProt PMID:9685362 NCBI chrNW_004936528:3,800,801...3,806,000
Ensembl chrNW_004936528:3,800,577...3,805,004 		JBrowse link
G Casr calcium sensing receptor ISO RGD PMID:22192592 RGD:7207059 NCBI chrNW_004936536:8,574,064...8,599,446
Ensembl chrNW_004936536:8,574,064...8,599,454 		JBrowse link
G Cck cholecystokinin ISO RGD PMID:12496267 RGD:1626097 NCBI chrNW_004936695:2,776,705...2,782,280
Ensembl chrNW_004936695:2,776,831...2,782,061 		JBrowse link
G Cckbr cholecystokinin B receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936842:329,551...341,491
Ensembl chrNW_004936842:329,376...341,808 		JBrowse link
G Cmklr2 chemerin chemokine-like receptor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936631:2,544,951...2,580,306
Ensembl chrNW_004936631:2,545,241...2,546,308 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO in transfected HEK cells RGD PMID:15932935 RGD:1626241 NCBI chrNW_004936541:2,288,847...2,333,129
Ensembl chrNW_004936541:2,288,841...2,331,689 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:19439178 RGD:5130951 NCBI chrNW_004936478:6,901,098...6,947,719
Ensembl chrNW_004936478:6,899,017...6,947,790 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:28,508,726...28,535,640
Ensembl chrNW_004936473:28,510,523...28,535,627 		JBrowse link
G Dgka diacylglycerol kinase alpha involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936646:351,589...367,985
Ensembl chrNW_004936646:351,414...369,971 		JBrowse link
G Dgkb diacylglycerol kinase beta involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936546:964,387...1,615,928
Ensembl chrNW_004936546:963,064...1,615,984 		JBrowse link
G Dgkd diacylglycerol kinase delta involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936525:3,826,929...3,897,618
Ensembl chrNW_004936525:3,828,939...3,897,529 		JBrowse link
G Dgkg diacylglycerol kinase gamma involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936578:3,572,424...3,762,270
Ensembl chrNW_004936578:3,572,245...3,761,617 		JBrowse link
G Dgkh diacylglycerol kinase eta involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936747:1,562,173...1,728,588
Ensembl chrNW_004936747:1,563,323...1,728,767 		JBrowse link
G Dgki diacylglycerol kinase iota involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936592:1,843,438...2,136,905
Ensembl chrNW_004936592:1,844,315...2,270,814 		JBrowse link
G Dgkk diacylglycerol kinase kappa involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936721:1,804,746...1,934,854
Ensembl chrNW_004936721:1,804,746...1,934,527 		JBrowse link
G Dgkq diacylglycerol kinase theta involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936477:22,225,624...22,238,825
Ensembl chrNW_004936477:22,225,618...22,238,803 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936562:2,690,907...2,733,455
Ensembl chrNW_004936562:2,690,858...2,733,620 		JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO (PMID:1331329) BHF-UCL PMID:1331329 NCBI chrNW_004936612:1,094,686...1,154,149
Ensembl chrNW_004936612:1,094,680...1,154,798 		JBrowse link
G Edn1 endothelin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2542249) Ensembl
MGI		 PMID:2542249 GO_REF:0000107 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Edn2 endothelin 2 ISO RGD PMID:1533364 RGD:1581817 NCBI chrNW_004936474:23,061,219...23,064,525
Ensembl chrNW_004936474:23,060,905...23,064,566 		JBrowse link
G Ednra endothelin receptor type A ISO RGD PMID:12628492 RGD:728499 NCBI chrNW_004936535:1,950,117...2,005,786
Ensembl chrNW_004936535:1,949,941...2,005,910 		JBrowse link
G Ednrb endothelin receptor type B ISO RGD PMID:15245872 RGD:1581866 NCBI chrNW_004936511:3,446,864...3,478,434
Ensembl chrNW_004936511:3,446,839...3,478,434 		JBrowse link
G Esr1 estrogen receptor 1 involved_in ISO PMID:15705806 UniProt PMID:15705806 RGD:8553914 NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171 		JBrowse link
G F2r coagulation factor II thrombin receptor involved_in IEA
ISO		 Ensembl
TreeGrafter
RGD		 PMID:12644441 PMID:15145074 GO_REF:0000107 GO_REF:0000118 RGD:1582290 RGD:1582293 NCBI chrNW_004936549:226,508...247,024
Ensembl chrNW_004936549:225,371...247,042 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936549:142,281...153,575
Ensembl chrNW_004936549:141,512...153,602 		JBrowse link
G F2rl2 coagulation factor II thrombin receptor like 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936549:336,871...342,992
Ensembl chrNW_004936549:337,024...342,948 		JBrowse link
G Ffar1 free fatty acid receptor 1 involved_in ISO (PMID:31664108) MGI PMID:31664108 NCBI chrNW_004936570:955,102...957,437 JBrowse link
G Ffar4 free fatty acid receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936601:1,413,236...1,434,036
Ensembl chrNW_004936601:1,413,208...1,433,455 		JBrowse link
G Fshr follicle stimulating hormone receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10330114) Ensembl
MGI		 PMID:10330114 GO_REF:0000107 NCBI chrNW_004936508:3,601,205...3,754,234
Ensembl chrNW_004936508:3,601,315...3,753,706 		JBrowse link
G Galr2 galanin receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:1,236,281...1,239,213
Ensembl chrNW_004936594:1,236,061...1,239,113 		JBrowse link
G Gna11 G protein subunit alpha 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:1,770,777...1,789,143
Ensembl chrNW_004936588:1,770,771...1,789,170 		JBrowse link
G Gna15 G protein subunit alpha 15 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10629036) RGD
MGI
Ensembl		 PMID:9685675 PMID:10629036 GO_REF:0000107 RGD:728647 NCBI chrNW_004936588:1,802,576...1,816,772
Ensembl chrNW_004936588:1,804,231...1,816,782 		JBrowse link
G Gnb1 G protein subunit beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10570481) Ensembl
MGI		 PMID:10570481 GO_REF:0000107 NCBI chrNW_004936737:1,518,855...1,554,926
Ensembl chrNW_004936737:1,524,325...1,555,102 		JBrowse link
G Gng13 G protein subunit gamma 13 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10570481) Ensembl
MGI
InterPro		 PMID:10570481 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936501:230,439...232,426
Ensembl chrNW_004936501:232,009...232,413 		JBrowse link
G Gpr139 G protein-coupled receptor 139 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16378626) Ensembl
TreeGrafter
MGI		 PMID:16378626 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936501:5,585,278...5,620,667
Ensembl chrNW_004936501:5,585,798...5,620,385 		JBrowse link
G Gpr143 G protein-coupled receptor 143 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936644:196,344...236,659
Ensembl chrNW_004936644:196,263...235,305 		JBrowse link
G Gpr157 G protein-coupled receptor 157 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936623:3,264,409...3,281,857
Ensembl chrNW_004936623:3,264,403...3,281,931 		JBrowse link
G Gpr17 G protein-coupled receptor 17 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936469:43,652,244...43,656,661
Ensembl chrNW_004936469:43,653,481...43,654,497 		JBrowse link
G Gpr174 G protein-coupled receptor 174 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936547:1,170,718...1,171,958
Ensembl chrNW_004936547:1,170,747...1,171,748 		JBrowse link
G Gpr18 G protein-coupled receptor 18 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936472:11,240,287...11,242,157
Ensembl chrNW_004936472:11,240,880...11,241,875 		JBrowse link
G Gpr20 G protein-coupled receptor 20 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:10,101,950...10,103,020
Ensembl chrNW_004936470:10,101,950...10,103,020 		JBrowse link
G Gpr33 G protein-coupled receptor 33 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936494:6,074,140...6,078,747
Ensembl chrNW_004936494:6,074,140...6,078,747 		JBrowse link
G Gpr35 G protein-coupled receptor 35 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936745:993,375...994,292
Ensembl chrNW_004936745:993,375...994,373 		JBrowse link
G Gpr4 G protein-coupled receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,999,218...2,001,176
Ensembl chrNW_004936706:1,999,340...2,000,428 		JBrowse link
G Gpr55 G protein-coupled receptor 55 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936525:5,869,416...5,888,789
Ensembl chrNW_004936525:5,869,416...5,888,789 		JBrowse link
G Gpr83 G protein-coupled receptor 83 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936674:541,934...553,191
Ensembl chrNW_004936674:541,934...553,677 		JBrowse link
G Grid1 glutamate ionotropic receptor delta type subunit 1 involved_in ISO (PMID:27276689) UniProt PMID:27276689 NCBI chrNW_004936804:487,609...1,182,335
Ensembl chrNW_004936804:488,427...1,182,100 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 involved_in ISO (PMID:27276689) UniProt PMID:27276689 NCBI chrNW_004936625:91,229...468,242
Ensembl chrNW_004936625:90,299...466,395 		JBrowse link
G Grpr gastrin releasing peptide receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:5,533,256...5,565,827
Ensembl chrNW_004936470:5,533,256...5,565,869 		JBrowse link
G Hcrt hypocretin neuropeptide precursor ISO RGD PMID:16247802 RGD:1600968 NCBI chrNW_004936490:17,007,001...17,008,363
Ensembl chrNW_004936490:17,006,997...17,008,369 		JBrowse link
G Hcrtr2 hypocretin receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15256537) Ensembl
MGI		 PMID:15256537 GO_REF:0000107 NCBI chrNW_004936476:5,838,663...5,933,174
Ensembl chrNW_004936476:5,838,830...5,933,207 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936499:1,002,083...1,109,446
Ensembl chrNW_004936499:1,004,732...1,109,377 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:7859920 RGD:1600108 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936577:3,896,455...4,198,396
Ensembl chrNW_004936577:3,896,390...4,198,411 		JBrowse link
G Kiss1 KiSS-1 metastasis suppressor ISO kisspeptin-10 peptide is 100% identical in rat, mouse and human RGD PMID:11457843 PMID:16222076 RGD:1357971 RGD:1599289 NCBI chrNW_004936567:584,443...595,045
Ensembl chrNW_004936567:584,443...586,837 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:3026357 GO_REF:0000107 GO_REF:0000118 RGD:2292621 NCBI chrNW_004936508:3,928,467...3,983,481
Ensembl chrNW_004936508:3,928,466...3,983,890 		JBrowse link
G LOC101956095 C-X-C chemokine receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:688,698...690,563
Ensembl chrNW_004936569:681,301...690,563 		JBrowse link
G LOC101963529 putative P2Y purinoceptor 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936547:1,004,802...1,005,832
Ensembl chrNW_004936547:1,004,846...1,005,832 		JBrowse link
G LOC101971238 free fatty acid receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:895,364...896,356
Ensembl chrNW_004936570:895,364...896,356 		JBrowse link
G LOC101971779 N-formyl peptide receptor 2-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004937026:169,334...170,717
Ensembl chrNW_004937026:167,935...170,389 		JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha involved_in ISO
IEA		 RGD
Ensembl		 PMID:9677408 GO_REF:0000107 RGD:1598490 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
G LOC101973797 fMet-Leu-Phe receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22859307) MGI
TreeGrafter
Ensembl		 PMID:22859307 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004937026:155,550...156,608
Ensembl chrNW_004937026:155,550...156,608 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936559:2,187,791...2,331,587
Ensembl chrNW_004936559:2,259,420...2,332,806 		JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936547:821,950...834,069
Ensembl chrNW_004936547:750,947...834,069 		JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936565:1,688,218...1,689,876
Ensembl chrNW_004936565:1,688,314...1,689,348 		JBrowse link
G Ltb4r leukotriene B4 receptor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936722:232,320...233,802 JBrowse link
G Mc1r melanocortin 1 receptor involved_in ISO (PMID:18292087) BHF-UCL PMID:18292087 NCBI chrNW_004936641:193,885...198,730 JBrowse link
G Myh9 myosin heavy chain 9 ISO RGD PMID:20068007 RGD:6902910 NCBI chrNW_004936492:4,384,215...4,466,229
Ensembl chrNW_004936492:4,384,215...4,466,262 		JBrowse link
G Nmur1 neuromedin U receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936525:5,355,570...5,386,284
Ensembl chrNW_004936525:5,382,372...5,385,788 		JBrowse link
G Npr3 natriuretic peptide receptor 3 ISO RGD PMID:15044621 RGD:1581459 NCBI chrNW_004936518:8,093,111...8,158,862
Ensembl chrNW_004936518:8,093,561...8,158,868 		JBrowse link
G Ntsr2 neurotensin receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8795617) Ensembl
MGI		 PMID:8795617 GO_REF:0000107 NCBI chrNW_004936532:7,525,354...7,533,489
Ensembl chrNW_004936532:7,525,133...7,533,489 		JBrowse link
G Oprd1 opioid receptor delta 1 involved_in ISO PMID:9572309 UniProt PMID:9572309 RGD:8553369 NCBI chrNW_004936474:12,860,293...12,902,389
Ensembl chrNW_004936474:12,860,293...12,903,466 		JBrowse link
G Oprk1 opioid receptor kappa 1 involved_in ISO PMID:9572309 UniProt PMID:9572309 RGD:8553369 NCBI chrNW_004936496:280,593...305,900
Ensembl chrNW_004936496:280,558...305,904 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:11,264,392...11,273,584
Ensembl chrNW_004936514:11,258,335...11,273,592 		JBrowse link
G Oprm1 opioid receptor mu 1 involved_in ISO PMID:9572309 UniProt PMID:9572309 RGD:8553369 NCBI chrNW_004936489:6,506,207...6,567,136
Ensembl chrNW_004936489:6,506,207...6,548,946 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 involved_in ISO (PMID:31664108) MGI PMID:31664108 NCBI chrNW_004936558:2,730,098...2,743,062 JBrowse link
G P2ry1 purinergic receptor P2Y1 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936519:865,756...872,466
Ensembl chrNW_004936519:866,208...872,393 		JBrowse link
G P2ry12 purinergic receptor P2Y12 involved_in ISO PMID:18183622
PMID:20091784		 ARUK-UCL PMID:18183622 PMID:20091784 RGD:13673786 RGD:6480646 NCBI chrNW_004936758:1,581,828...1,624,332
Ensembl chrNW_004936758:1,581,897...1,592,222 		JBrowse link
G P2ry2 purinergic receptor P2Y2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936498:2,432,436...2,444,495
Ensembl chrNW_004936498:2,432,448...2,444,354 		JBrowse link
G P2ry8 P2Y receptor family member 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936644:3,768,646...3,770,610
Ensembl chrNW_004936644:3,768,463...3,770,500 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma involved_in ISO (PMID:22728827) UniProt PMID:22728827 NCBI chrNW_004936479:17,084,006...17,112,264
Ensembl chrNW_004936479:17,084,920...17,112,258 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:10,548,966...11,254,139
Ensembl chrNW_004936485:10,548,966...11,253,761 		JBrowse link
G Plcb2 phospholipase C beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:3,756,978...3,776,452
Ensembl chrNW_004936471:3,756,970...3,776,392 		JBrowse link
G Plcb3 phospholipase C beta 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:4,934,123...4,950,564
Ensembl chrNW_004936599:4,934,060...4,950,570 		JBrowse link
G Plcd1 phospholipase C delta 1 ISO RGD PMID:16709602 RGD:2300424 NCBI chrNW_004936473:27,364,404...27,387,337
Ensembl chrNW_004936473:27,364,389...27,387,412 		JBrowse link
G Plce1 phospholipase C epsilon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936601:817,151...1,105,824
Ensembl chrNW_004936601:816,190...1,105,830 		JBrowse link
G Plch2 phospholipase C eta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936737:1,066,860...1,131,627
Ensembl chrNW_004936737:1,066,825...1,133,216 		JBrowse link
G Plek pleckstrin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:12,762,421...12,818,249
Ensembl chrNW_004936491:12,762,328...12,818,306 		JBrowse link
G Prkcg protein kinase C gamma involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936994:87,525...105,125
Ensembl chrNW_004936994:87,519...105,134 		JBrowse link
G Prkd1 protein kinase D1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936494:4,469,092...4,601,183
Ensembl chrNW_004936494:4,469,089...4,601,214 		JBrowse link
G Prkd2 protein kinase D2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936664:524,532...551,451
Ensembl chrNW_004936664:522,910...551,469 		JBrowse link
G Prkd3 protein kinase D3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936663:979,136...1,047,633
Ensembl chrNW_004936663:979,130...1,049,427 		JBrowse link
G Ptafr platelet activating factor receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:12,333,905...12,337,140
Ensembl chrNW_004936474:12,336,071...12,337,099 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936581:2,069,355...2,072,535
Ensembl chrNW_004936581:2,067,546...2,070,893 		JBrowse link
G Ptger3 prostaglandin E receptor 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7945376) MGI
TreeGrafter		 PMID:7945376 GO_REF:0000118 NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410 		JBrowse link
G Pth1r parathyroid hormone 1 receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12194850) RGD
MGI
Ensembl		 PMID:9054374 PMID:12194850 GO_REF:0000107 RGD:7207455 NCBI chrNW_004936596:674,088...693,191
Ensembl chrNW_004936596:674,088...693,213 		JBrowse link
G Rasgrp4 RAS guanyl releasing protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936801:1,166,676...1,180,508
Ensembl chrNW_004936801:1,167,708...1,180,508 		JBrowse link
G Rxfp3 relaxin family peptide receptor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16378626) Ensembl
MGI		 PMID:16378626 GO_REF:0000107 NCBI chrNW_004936518:7,140,512...7,143,656 JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO RGD PMID:9765227 RGD:1581785 NCBI chrNW_004936748:1,244,962...1,250,093
Ensembl chrNW_004936748:1,245,538...1,250,093 		JBrowse link
G Sele selectin E involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:16,915,203...16,921,840
Ensembl chrNW_004936481:16,915,182...16,921,840 		JBrowse link
G Stim1 stromal interaction molecule 1 involved_in ISO (PMID:31664108)
(PMID:30131394), (PMID:31664108)		 MGI PMID:30131394 PMID:31664108 NCBI chrNW_004936498:849,775...1,063,552
Ensembl chrNW_004936498:849,739...1,063,552 		JBrowse link
G Taar1 trace amine associated receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:675,500...676,522
Ensembl chrNW_004936560:675,500...676,522 		JBrowse link
G Tgm2 transglutaminase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 PMID:7911253 MGI
Ensembl		 PMID:7911253 GO_REF:0000107 RGD:8553754 NCBI chrNW_004936561:3,178,244...3,207,551
Ensembl chrNW_004936561:3,178,293...3,207,561 		JBrowse link
G Trhr thyrotropin releasing hormone receptor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:35,808,569...35,844,062
Ensembl chrNW_004936470:35,806,397...35,844,267 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:6,031,627...6,052,211
Ensembl chrNW_004936473:6,029,976...6,052,159 		JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bicd1 BICD cargo adaptor 1 involved_in ISO PMID:20164183
(PMID:20164183)		 BHF-UCL PMID:20164183 RGD:8693367 NCBI chrNW_004936607:3,893,350...4,126,813
Ensembl chrNW_004936607:3,895,634...4,126,880 		JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:18,893,958...19,022,450
Ensembl chrNW_004936486:18,893,909...19,022,477 		JBrowse link
phospholipase C-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in ISO PMID:19011682 BHF-UCL PMID:19011682 RGD:5688340 NCBI chrNW_004936757:149,366...237,710
Ensembl chrNW_004936757:150,496...237,710 		JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:1,837,785...1,841,019
Ensembl chrNW_004936486:1,838,176...1,839,630 		JBrowse link
phospholipase C-activating angiotensin-activated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:16,186,844...16,248,394
Ensembl chrNW_004936484:16,186,642...16,248,400 		JBrowse link
G Agtr1 angiotensin II receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G LOC101965218 proto-oncogene Mas involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:11,366,657...11,367,631
Ensembl chrNW_004936489:11,366,657...11,367,631 		JBrowse link
phospholipase C-activating dopamine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15016423)
(PMID:17194762)		 Ensembl
MGI		 PMID:15016423 PMID:17194762 GO_REF:0000107 NCBI chrNW_004936609:790,647...795,187
Ensembl chrNW_004936609:792,276...793,613 		JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17194762)
(PMID:15016423)		 MGI
TreeGrafter
Ensembl		 PMID:15016423 PMID:17194762 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936612:1,094,686...1,154,149
Ensembl chrNW_004936612:1,094,680...1,154,798 		JBrowse link
G Drd3 dopamine receptor D3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936536:1,580,732...1,616,726
Ensembl chrNW_004936536:1,580,732...1,616,725 		JBrowse link
G Drd4 dopamine receptor D4 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936888:468,334...471,254
Ensembl chrNW_004936888:468,403...471,205 		JBrowse link
G Gna11 G protein subunit alpha 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17194762) Ensembl
TreeGrafter
MGI		 PMID:17194762 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936588:1,770,777...1,789,143
Ensembl chrNW_004936588:1,770,771...1,789,170 		JBrowse link
G Gna15 G protein subunit alpha 15 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936588:1,802,576...1,816,772
Ensembl chrNW_004936588:1,804,231...1,816,782 		JBrowse link
G LOC101971412 guanine nucleotide-binding protein subunit alpha-14 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936503:12,860,296...13,056,880
Ensembl chrNW_004936503:12,859,715...13,056,244 		JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha acts_upstream_of_or_within ISO (PMID:17194762) MGI PMID:17194762 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20200151) Ensembl
MGI		 PMID:20200151 GO_REF:0000107 NCBI chrNW_004936594:119,808...136,620
Ensembl chrNW_004936594:119,770...136,789 		JBrowse link
phospholipase C-activating endothelin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcb4 phospholipase C beta 4 involved_in ISO (PMID:35284927) UniProt PMID:35284927 NCBI chrNW_004936485:9,991,731...10,353,231
Ensembl chrNW_004936485:9,991,299...10,353,123 		JBrowse link
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa7 annexin A7 acts_upstream_of_or_within_positive_effect ISO (PMID:10570150) MGI PMID:10570150 NCBI chrNW_004936521:5,639,193...5,671,369
Ensembl chrNW_004936521:5,651,719...5,671,050 		JBrowse link
G Chrm3 cholinergic receptor muscarinic 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:13,953,141...14,373,174
Ensembl chrNW_004936484:13,954,887...13,956,659 		JBrowse link
G Gna11 G protein subunit alpha 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:1,770,777...1,789,143
Ensembl chrNW_004936588:1,770,771...1,789,170 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936577:3,896,455...4,198,396
Ensembl chrNW_004936577:3,896,390...4,198,411 		JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha involved_in ISO (PMID:20440069) MGI PMID:20440069 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:10,548,966...11,254,139
Ensembl chrNW_004936485:10,548,966...11,253,761 		JBrowse link
G Prkcb protein kinase C beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:8,410,273...8,729,238
Ensembl chrNW_004936501:8,437,715...8,728,716 		JBrowse link
G Stim1 stromal interaction molecule 1 involved_in ISO (PMID:18452988) MGI PMID:18452988 NCBI chrNW_004936498:849,775...1,063,552
Ensembl chrNW_004936498:849,739...1,063,552 		JBrowse link
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna11 G protein subunit alpha 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:1,770,777...1,789,143
Ensembl chrNW_004936588:1,770,771...1,789,170 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chrNW_004936625:91,229...468,242
Ensembl chrNW_004936625:90,299...466,395 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in IEA UniProt
Ensembl		 GO_REF:0000107 GO_REF:0000117 NCBI chrNW_004936736:623,118...1,060,273
Ensembl chrNW_004936736:623,013...1,064,054 		JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
phospholipase C-activating serotonin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna11 G protein subunit alpha 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:1,770,777...1,789,143
Ensembl chrNW_004936588:1,770,771...1,789,170 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936890:154,252...157,044
Ensembl chrNW_004936890:155,233...156,408 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:17010161 GO_REF:0000107 GO_REF:0000118 RGD:1624387 NCBI chrNW_004936565:335,238...394,683
Ensembl chrNW_004936565:334,393...394,715 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936525:5,711,894...5,729,074
Ensembl chrNW_004936525:5,712,329...5,729,831 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:12435801 GO_REF:0000107 GO_REF:0000118 RGD:1598460 NCBI chrNW_004936499:1,002,083...1,109,446
Ensembl chrNW_004936499:1,004,732...1,109,377 		JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
G Plcb3 phospholipase C beta 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:4,934,123...4,950,564
Ensembl chrNW_004936599:4,934,060...4,950,570 		JBrowse link
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A ISO RGD PMID:11257446 RGD:6907050 NCBI chrNW_004936733:915,700...927,220
Ensembl chrNW_004936733:915,830...927,409 		JBrowse link
G F2 coagulation factor II, thrombin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650 		JBrowse link
G Gpr27 G protein-coupled receptor 27 acts_upstream_of_or_within ISO (PMID:22253604) MGI PMID:22253604 NCBI chrNW_004936603:3,241,741...3,289,996 JBrowse link
G Grp gastrin releasing peptide involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:5,473,293...5,487,344
Ensembl chrNW_004936497:5,476,800...5,487,358 		JBrowse link
G Nrxn1 neurexin 1 involved_in ISO (PMID:26078884) ARUK-UCL PMID:26078884 NCBI chrNW_004936508:1,889,640...2,954,039 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16037
    cellular process 15650
      signal transduction 5694
        G protein-coupled receptor signaling pathway 1536
          phospholipase C-activating G protein-coupled receptor signaling pathway 141
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 2
            phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 8
            phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 4
            phospholipase C-activating adrenergic receptor signaling pathway 2
            phospholipase C-activating angiotensin-activated signaling pathway + 3
            phospholipase C-activating dopamine receptor signaling pathway + 9
            phospholipase C-activating endothelin receptor signaling pathway 1
            phospholipase C-activating opsin-mediated signaling pathway + 0
            phospholipase C-activating serotonin receptor signaling pathway 7
            phospholipase C-activating tachykinin receptor signaling pathway 0
            positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 5
            regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 7
Path 2
Term Annotations click to browse term
  biological_process 16037
    biological regulation 11269
      regulation of biological process 10908
        signaling 6187
          signal transduction 5694
            G protein-coupled receptor signaling pathway 1536
              phospholipase C-activating G protein-coupled receptor signaling pathway 141
                negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 2
                phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 8
                phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 4
                phospholipase C-activating adrenergic receptor signaling pathway 2
                phospholipase C-activating angiotensin-activated signaling pathway + 3
                phospholipase C-activating dopamine receptor signaling pathway + 9
                phospholipase C-activating endothelin receptor signaling pathway 1
                phospholipase C-activating opsin-mediated signaling pathway + 0
                phospholipase C-activating serotonin receptor signaling pathway 7
                phospholipase C-activating tachykinin receptor signaling pathway 0
                positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 5
                regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 7
paths to the root