Agtr1 (angiotensin II receptor type 1) - Rat Genome Database

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Gene: Agtr1 (angiotensin II receptor type 1) Ictidomys tridecemlineatus
Analyze
Symbol: Agtr1
Name: angiotensin II receptor type 1
RGD ID: 12578538
Description: ENCODES a protein that exhibits angiotensin type I receptor activity (ortholog); D1 dopamine receptor binding (ortholog); protein kinase binding (ortholog); INVOLVED IN activation of Janus kinase activity (ortholog); cellular response to dexamethasone stimulus (ortholog); dopamine biosynthetic process (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); aceruloplasminemia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN basolateral plasma membrane (ortholog); cytoplasmic vesicle (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: type-1 angiotensin II receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560282,859,961 - 82,902,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,831,096 - 6,873,985 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,831,096 - 6,873,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
aceruloplasminemia  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
cerebrovascular disease  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (ISO)
essential hypertension  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Friedreich ataxia  (ISO)
genetic disease  (ISO)
glomerulosclerosis  (ISO)
glycogen storage disease XV  (ISO)
Huntington's disease  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
IgA glomerulonephritis  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
patent ductus arteriosus  (ISO)
Pituitary Neoplasms  (ISO)
placental insufficiency  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
sarcoidosis  (ISO)
Spontaneous Abortions  (ISO)
Ventricular Remodeling  (ISO)
vesicoureteral reflux  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (ISO)
angiotensin-activated signaling pathway  (IEA)
calcium-mediated signaling  (IEA)
cell chemotaxis  (IEA)
cellular response to dexamethasone stimulus  (ISO)
chemokine-mediated signaling pathway  (IEA)
dopamine biosynthetic process  (ISO)
drinking behavior  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
immune response  (IEA)
kidney development  (IEA)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (IEA)
neutrophil chemotaxis  (IEA)
phospholipase C-activating angiotensin-activated signaling pathway  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of phospholipase A2 activity  (ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of receptor recycling  (ISO)
positive regulation of superoxide anion generation  (ISO)
regulation of pH  (ISO)
regulation of vasoconstriction  (IEA)
renin-angiotensin regulation of aldosterone production  (ISO)
response to activity  (ISO)
response to angiotensin  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to salt stress  (ISO)
Rho protein signal transduction  (IEA)
symbiont entry into host cell  (IEA)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway   (ISO)
angiotensin II signaling pathway   (ISO)
angiotensin II signaling pathway via AT1 receptor  (ISO)
angiotensin III signaling pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
benazepril pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
candesartan pharmacodynamics pathway  (ISO)
captopril pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
cilazapril pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
enalapril pharmacodynamics pathway  (ISO)
eprosartan pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forasartsn pharmacodynamics pathway  (ISO)
fosinopril pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galpha12/Galpha13 family  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
irbesartan pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lisinopril pharmacodynamics pathway   (ISO)
losartan pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
moexipril pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
olmesartan pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
perindopril pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinapril pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
ramipril pharmacodynamics pathway   (ISO)
renin-angiotensin cascade pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spirapril pharmacodynamics pathway  (ISO)
telmisartan pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
trandolapril pharmacodynamics pathway  (ISO)
valsartan pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Agtr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560282,859,961 - 82,902,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,831,096 - 6,873,985 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,831,096 - 6,873,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36Build 36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
T2T-CHM13v2.03151,448,936 - 151,494,033 (+)NCBIT2T-CHM13v2.0
Agtr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,368,637 - 20,421,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl320,368,637 - 20,421,341 (-)EnsemblGRCm39 Ensembl
GRCm38320,314,473 - 20,367,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl320,314,473 - 20,367,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv37320,213,395 - 20,266,099 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36320,505,546 - 20,558,250 (-)NCBIMGSCv36mm8
Celera320,303,573 - 20,356,081 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.37NCBI
Agtr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,383,397 - 34,435,523 (-)NCBIGRCr8
mRatBN7.21734,173,446 - 34,226,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
Agtr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,733,942 - 8,781,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,733,942 - 8,781,305 (-)NCBIChiLan1.0ChiLan1.0
AGTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,594,053 - 146,639,172 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13146,599,078 - 146,643,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03145,722,475 - 145,767,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13153,301,331 - 153,346,268 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,341,947 - 153,345,380 (+)Ensemblpanpan1.1panPan2
AGTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,569,658 - 43,617,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,614,035 - 43,616,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2343,434,074 - 43,481,582 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02344,190,631 - 44,238,133 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12343,779,664 - 43,827,179 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02343,832,799 - 43,880,312 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02344,086,806 - 44,134,323 (+)NCBIUU_Cfam_GSD_1.0
AGTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1388,934,868 - 88,983,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11388,934,873 - 88,980,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21396,933,114 - 96,978,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,957,826 - 42,002,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604114,800,710 - 14,845,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agtr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473025,964,811 - 26,006,463 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473025,964,848 - 26,006,468 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005325721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000021718   ⟹   ENSSTOP00000016773
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365196,831,096 - 6,873,985 (-)Ensembl
RefSeq Acc Id: XM_005325721   ⟹   XP_005325778
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560282,859,961 - 82,902,941 (+)NCBI
SpeTri2.0NW_0049365196,831,096 - 6,873,977 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005325778 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000016773.1
GenBank Protein KAG3270801 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005325778   ⟸   XM_005325721
- UniProtKB: I3MXC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000016773   ⟸   ENSSTOT00000021718
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025945 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021718.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro ATII_AT1_rcpt UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/TrEMBL
  GPCR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Agtr1 ENTREZGENE
PANTHER APELIN RECEPTOR UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ANGIOTENSINR UniProtKB/TrEMBL
  ANGIOTENSN1R UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt I3MXC8 ENTREZGENE, UniProtKB/TrEMBL