Ptafr (platelet activating factor receptor) - Rat Genome Database
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Gene: Ptafr (platelet activating factor receptor) Ictidomys tridecemlineatus
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Symbol: Ptafr
Name: platelet activating factor receptor
RGD ID: 12623953
Description: ENCODES a protein that exhibits lipopolysaccharide binding (ortholog); lipopolysaccharide immune receptor activity (ortholog); mitogen-activated protein kinase binding (ortholog); INVOLVED IN cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine (ortholog); cellular response to cAMP (ortholog); cellular response to fatty acid (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); conjunctivitis (ortholog); FOUND IN membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: platelet-activating factor receptor
Orthologs:
Homo sapiens (human) : PTAFR (platelet activating factor receptor)  HGNC  Alliance
Mus musculus (house mouse) : Ptafr (platelet-activating factor receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptafr (platelet-activating factor receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptafr (platelet activating factor receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : PTAFR (platelet activating factor receptor)
Canis lupus familiaris (dog) : PTAFR (platelet activating factor receptor)
Sus scrofa (pig) : PTAFR (platelet activating factor receptor)
Chlorocebus sabaeus (African green monkey) : PTAFR (platelet activating factor receptor)
Heterocephalus glaber (naked mole-rat) : Ptafr (platelet activating factor receptor)
more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647412,333,905 - 12,337,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  (ISO)
cellular response to cAMP  (ISO)
cellular response to fatty acid  (ISO)
cellular response to gravity  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
inflammatory response  (ISO)
inositol trisphosphate biosynthetic process  (ISO)
negative regulation of blood pressure  (ISO)
obsolete positive regulation of blood vessel diameter  (ISO)
parturition  (ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of cellular extravasation  (ISO)
positive regulation of gastro-intestinal system smooth muscle contraction  (ISO)
positive regulation of inositol phosphate biosynthetic process  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of leukocyte cell-cell adhesion  (ISO)
positive regulation of leukocyte tethering or rolling  (ISO)
positive regulation of maternal process involved in parturition  (ISO)
positive regulation of neutrophil degranulation  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of transcytosis  (ISO)
positive regulation of translation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vasoconstriction  (ISO)
positive regulation of voltage-gated chloride channel activity  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  (ISO)
response to dexamethasone  (ISO)
response to lipopolysaccharide  (ISO)
response to organophosphorus  (ISO)
response to symbiotic bacterium  (ISO)
transcytosis  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Ptafr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647412,333,905 - 12,337,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTAFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl128,147,166 - 28,193,936 (-)EnsemblGRCh38hg38GRCh38
GRCh38128,147,166 - 28,193,856 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37128,473,677 - 28,520,447 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,348,425 - 28,375,778 (-)NCBINCBI36hg18NCBI36
Build 34128,160,005 - 28,187,333NCBI
Celera126,869,321 - 26,916,090 (-)NCBI
Cytogenetic Map1p35.3NCBI
HuRef126,730,992 - 26,777,615 (-)NCBIHuRef
CHM1_1128,589,192 - 28,635,951 (-)NCBICHM1_1
Ptafr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,291,378 - 132,309,994 (+)NCBI
GRCm384132,564,067 - 132,582,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,564,067 - 132,582,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,119,982 - 132,136,781 (+)NCBIGRCm37mm9NCBIm37
MGSCv364131,836,143 - 131,852,942 (+)NCBImm8
Celera4130,724,940 - 130,741,731 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.56NCBI
Ptafr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05150,746,284 - 150,775,675 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,754,021 - 150,775,672 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,414,542 - 154,443,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,565,687 - 152,587,342 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15152,575,728 - 152,597,381 (-)NCBI
Celera5143,199,712 - 143,221,168 (+)NCBICelera
Cytogenetic Map5q36NCBI
Ptafr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,311,901 - 7,312,929 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,309,854 - 7,345,579 (-)NCBIChiLan1.0ChiLan1.0
PTAFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1128,447,178 - 28,474,623 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,447,833 - 28,448,861 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,405,880 - 27,436,184 (-)NCBIMhudiblu_PPA_v0panPan3
PTAFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl272,225,386 - 72,256,352 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1272,225,386 - 72,256,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
PTAFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,235,390 - 85,272,333 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,235,390 - 85,272,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2684,789,514 - 84,851,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTAFR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20104,657,179 - 104,658,207 (+)Ensembl
ChlSab1.120104,627,591 - 104,658,840 (+)NCBI
Ptafr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476411,996,454 - 12,025,751 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013363249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGTP01007891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_013363249   ⟹   XP_013218703
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493647412,333,905 - 12,337,140 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013218703 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013218703   ⟸   XM_013363249
- UniProtKB: I3MQL6 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000015934 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000014258 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000015934 ENTREZGENE, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  PAF_rcpt UniProtKB/TrEMBL
NCBI Gene Ptafr ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PAFRECEPTOR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
UniProt I3MQL6 ENTREZGENE, UniProtKB/TrEMBL