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ONTOLOGY REPORT - ANNOTATIONS


Term:G protein-coupled receptor signaling pathway
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Accession:GO:0007186 term browser browse the term
Definition:A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
Synonyms:exact_synonym: G protein coupled receptor protein signaling pathway;   G protein coupled receptor protein signalling pathway;   G-protein coupled receptor protein signal transduction;   G-protein coupled receptor signalling pathway;   GPCR signaling pathway;   GPCR signalling pathway
 narrow_synonym: G-protein coupled receptor signaling pathway via GPCR dimer;   dimeric G-protein coupled receptor signaling pathway;   dimeric G-protein coupled receptor signalling pathway
 alt_id: GO:0038042


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    Path 1
    Term Annotations click to browse term
      biological_process 19612
        signaling 7527
          signal transduction 6956
            G protein-coupled receptor signaling pathway 2377
              G protein-coupled acetylcholine receptor signaling pathway + 14
              G protein-coupled glutamate receptor signaling pathway + 20
              G protein-coupled opioid receptor signaling pathway + 11
              G protein-coupled purinergic receptor signaling pathway + 14
              G protein-coupled receptor signaling in absence of ligand 0
              G protein-coupled receptor signaling pathway involved in dauer larval development 0
              G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium 0
              G protein-coupled receptor signaling pathway involved in heart process + 12
              G protein-coupled receptor signaling pathway involved in social behavior 0
              G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger + 49
              G protein-coupled serotonin receptor signaling pathway + 41
              adenylate cyclase-modulating G protein-coupled receptor signaling pathway + 229
              adrenergic receptor signaling pathway + 30
              angiotensin-activated signaling pathway + 17
              apelin receptor signaling pathway 4
              bombesin receptor signaling pathway 3
              calcitonin family receptor signaling pathway + 8
              cannabinoid signaling pathway + 9
              cholecystokinin signaling pathway + 2
              complement component C5a signaling pathway 2
              endothelin receptor signaling pathway + 8
              follicle-stimulating hormone signaling pathway 9
              gastric inhibitory peptide signaling pathway 1
              ion channel modulating, G protein-coupled receptor signaling pathway + 0
              leukotriene signaling pathway 5
              luteinizing hormone signaling pathway + 3
              negative regulation of G protein-coupled receptor signaling pathway + 62
              neuropeptide signaling pathway + 104
              octopamine or tyramine signaling pathway + 0
              phospholipase C-activating G protein-coupled receptor signaling pathway + 100
              phospholipase C-inhibiting G protein-coupled receptor signaling pathway 1
              phospholipase D-activating G protein-coupled receptor signaling pathway 2
              positive regulation of G protein-coupled receptor signaling pathway + 31
              protein kinase C-activating G protein-coupled receptor signaling pathway 28
              regulation of G protein-coupled receptor signaling pathway + 134
              rhodopsin mediated signaling pathway + 8
              somatostatin receptor signaling pathway + 5
              sphingosine-1-phosphate receptor signaling pathway 14
              tachykinin receptor signaling pathway + 9
              thrombin-activated receptor signaling pathway + 11
              thromboxane A2 signaling pathway 1
              thyroid-stimulating hormone signaling pathway 1
    Path 2
    Term Annotations click to browse term
      biological_process 19612
        biological regulation 13583
          regulation of biological process 12857
            regulation of cellular process 12354
              signal transduction 6956
                G protein-coupled receptor signaling pathway 2377
                  G protein-coupled acetylcholine receptor signaling pathway + 14
                  G protein-coupled glutamate receptor signaling pathway + 20
                  G protein-coupled opioid receptor signaling pathway + 11
                  G protein-coupled purinergic receptor signaling pathway + 14
                  G protein-coupled receptor signaling in absence of ligand 0
                  G protein-coupled receptor signaling pathway involved in dauer larval development 0
                  G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium 0
                  G protein-coupled receptor signaling pathway involved in heart process + 12
                  G protein-coupled receptor signaling pathway involved in social behavior 0
                  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger + 49
                  G protein-coupled serotonin receptor signaling pathway + 41
                  adenylate cyclase-modulating G protein-coupled receptor signaling pathway + 229
                  adrenergic receptor signaling pathway + 30
                  angiotensin-activated signaling pathway + 17
                  apelin receptor signaling pathway 4
                  bombesin receptor signaling pathway 3
                  calcitonin family receptor signaling pathway + 8
                  cannabinoid signaling pathway + 9
                  cholecystokinin signaling pathway + 2
                  complement component C5a signaling pathway 2
                  endothelin receptor signaling pathway + 8
                  follicle-stimulating hormone signaling pathway 9
                  gastric inhibitory peptide signaling pathway 1
                  ion channel modulating, G protein-coupled receptor signaling pathway + 0
                  leukotriene signaling pathway 5
                  luteinizing hormone signaling pathway + 3
                  negative regulation of G protein-coupled receptor signaling pathway + 62
                  neuropeptide signaling pathway + 104
                  octopamine or tyramine signaling pathway + 0
                  phospholipase C-activating G protein-coupled receptor signaling pathway + 100
                  phospholipase C-inhibiting G protein-coupled receptor signaling pathway 1
                  phospholipase D-activating G protein-coupled receptor signaling pathway 2
                  positive regulation of G protein-coupled receptor signaling pathway + 31
                  protein kinase C-activating G protein-coupled receptor signaling pathway 28
                  regulation of G protein-coupled receptor signaling pathway + 134
                  rhodopsin mediated signaling pathway + 8
                  somatostatin receptor signaling pathway + 5
                  sphingosine-1-phosphate receptor signaling pathway 14
                  tachykinin receptor signaling pathway + 9
                  thrombin-activated receptor signaling pathway + 11
                  thromboxane A2 signaling pathway 1
                  thyroid-stimulating hormone signaling pathway 1
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