Wnt5a (Wnt family member 5A) - Rat Genome Database

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Gene: Wnt5a (Wnt family member 5A) Ictidomys tridecemlineatus
Analyze
Symbol: Wnt5a
Name: Wnt family member 5A
RGD ID: 12599950
Description: ENCODES a protein that exhibits chemoattractant activity involved in axon guidance (inferred); cytokine activity (inferred); frizzled binding (inferred); INVOLVED IN activation of GTPase activity (ortholog); activation of protein kinase B activity (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); colon cancer (ortholog); Dwarfism (ortholog); FOUND IN extracellular space (ortholog); glutamatergic synapse (ortholog); Schaffer collateral - CA1 synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118172,893,045 - 172,913,645 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364736,029,976 - 6,052,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364736,031,627 - 6,052,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
activation of protein kinase B activity  (ISO)
anterior/posterior axis specification, embryo  (IEA)
anterior/posterior pattern specification  (IEA,ISO)
atrial septum development  (IEA)
axis elongation  (IEA,ISO)
axon extension involved in axon guidance  (IEA,ISO)
axon guidance  (IEA)
axonogenesis  (IEA)
BMP signaling pathway  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (ISO)
cell fate commitment  (IEA)
cell migration  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to calcium ion  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to molecule of bacterial origin  (IEA)
cellular response to transforming growth factor beta stimulus  (IEA)
cellular response to type II interferon  (IEA)
cervix development  (IEA,ISO)
chemoattraction of serotonergic neuron axon  (IEA)
chemorepulsion of dopaminergic neuron axon  (IEA)
cochlea morphogenesis  (IEA,ISO)
convergent extension  (IEA,ISO)
convergent extension involved in axis elongation  (IEA,ISO)
convergent extension involved in organogenesis  (IEA,ISO)
determination of left/right symmetry  (IEA,ISO)
development of primary male sexual characteristics  (IEA,ISO)
digestive tract morphogenesis  (IEA,ISO)
dopaminergic neuron differentiation  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
embryonic skeletal system development  (IEA)
epithelial cell migration  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
epithelial to mesenchymal transition  (IEA)
establishment of epithelial cell apical/basal polarity  (IEA,ISO)
establishment of planar polarity  (IEA,ISO)
estrous cycle  (ISO)
face development  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
genitalia development  (IEA)
heart looping  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
hindgut morphogenesis  (IEA,ISO)
hypophysis morphogenesis  (IEA,ISO)
inflammatory response  (IEA)
inner ear morphogenesis  (IEA,ISO)
JNK cascade  (IEA,ISO)
keratinocyte differentiation  (IEA)
kidney development  (IEA,ISO)
lateral sprouting involved in mammary gland duct morphogenesis  (IEA,ISO)
limb morphogenesis  (IEA,ISO)
lung alveolus development  (ISO)
lung development  (IEA,ISO)
macrophage derived foam cell differentiation  (IEA)
male gonad development  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
meiotic nuclear division  (IEA,ISO)
melanocyte proliferation  (IEA)
mesenchymal cell proliferation  (IEA,ISO)
mesenchymal-epithelial cell signaling  (IEA,ISO)
mesodermal to mesenchymal transition involved in gastrulation  (IEA,ISO)
midbrain development  (IEA)
midbrain dopaminergic neuron differentiation  (IEA)
midgut development  (IEA,ISO)
modulation of chemical synaptic transmission  (ISO)
morphogenesis of an epithelium  (IEA,ISO)
negative chemotaxis  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of axon extension involved in axon guidance  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell proliferation in midbrain  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA)
negative regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of melanin biosynthetic process  (IEA)
negative regulation of mesenchymal cell proliferation  (IEA)
negative regulation of prostatic bud formation  (IEA,ISO)
negative regulation of synapse assembly  (IEA)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
neurogenesis  (IEA)
neuron differentiation  (IEA,ISO)
neuron projection morphogenesis  (IEA)
non-canonical Wnt signaling pathway  (IEA,ISO)
notochord morphogenesis  (IEA,ISO)
olfactory bulb interneuron development  (IEA)
paraxial mesoderm formation  (IEA,ISO)
pericardium morphogenesis  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic signaling pathway  (IEA)
positive regulation of cartilage development  (IEA,ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cell-cell adhesion mediated by cadherin  (IEA,ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of cytokine production involved in immune response  (IEA)
positive regulation of dendrite extension  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of GTPase activity  (ISO)
positive regulation of hematopoietic stem cell proliferation  (IEA,ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of JUN kinase activity  (ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of macrophage cytokine production  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of meiotic nuclear division  (IEA,ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of neuron projection arborization  (IEA)
positive regulation of neuron projection development  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of non-canonical Wnt signaling pathway  (IEA)
positive regulation of ossification  (IEA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of response to cytokine stimulus  (IEA)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of thymocyte apoptotic process  (IEA,ISO)
positive regulation of timing of anagen  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon-mediated signaling pathway  (IEA)
positive regulation of type II interferon production  (IEA)
post-anal tail morphogenesis  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (IEA)
primary heart field specification  (IEA)
primitive streak formation  (IEA,ISO)
prostate gland development  (ISO)
protein localization  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of branching involved in mammary gland duct morphogenesis  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (IEA)
regulation of postsynapse organization  (IEA)
regulation of postsynaptic cytosolic calcium ion concentration  (IEA)
regulation of postsynaptic specialization assembly  (ISO)
regulation of protein localization  (IEA,ISO)
regulation of synapse organization  (IEA)
regulation of synaptic signaling by nitric oxide  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to hyperoxia  (ISO)
response to organic cyclic compound  (ISO)
response to quercetin  (ISO)
response to testosterone  (ISO)
secondary heart field specification  (IEA)
secondary palate development  (IEA)
somite development  (IEA,ISO)
somitogenesis  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
thymocyte apoptotic process  (IEA,ISO)
tube closure  (IEA,ISO)
type B pancreatic cell development  (IEA,ISO)
urinary bladder development  (IEA,ISO)
uterus development  (IEA,ISO)
vagina development  (IEA,ISO)
ventricular septum development  (IEA)
Wnt signaling pathway  (IEA,ISO)
Wnt signaling pathway, calcium modulating pathway  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)
wound healing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wnt5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118172,893,045 - 172,913,645 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364736,029,976 - 6,052,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364736,031,627 - 6,052,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38355,465,715 - 55,505,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl355,465,715 - 55,490,539 (-)EnsemblGRCh38hg38GRCh38
GRCh37355,499,743 - 55,521,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36355,474,783 - 55,496,371 (-)NCBINCBI36Build 36hg18NCBI36
Build 34355,474,783 - 55,496,371NCBI
Celera355,465,957 - 55,488,272 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef355,548,623 - 55,570,480 (-)NCBIHuRef
CHM1_1355,451,089 - 55,473,010 (-)NCBICHM1_1
T2T-CHM13v2.0355,499,921 - 55,539,460 (-)NCBIT2T-CHM13v2.0
Wnt5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391428,224,962 - 28,249,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1428,226,707 - 28,249,405 (+)EnsemblGRCm39 Ensembl
GRCm381428,504,543 - 28,527,448 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1428,504,750 - 28,527,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv371429,318,659 - 29,338,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361427,332,339 - 27,352,300 (+)NCBIMGSCv36mm8
Celera1424,754,276 - 24,774,180 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.8NCBI
Wnt5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8163,702,300 - 3,724,860 (+)NCBIGRCr8
mRatBN7.2163,697,032 - 3,718,230 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl163,697,032 - 3,718,234 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx163,703,581 - 3,724,806 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0164,848,997 - 4,870,222 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0163,708,537 - 3,729,736 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,469,451 - 4,490,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,469,468 - 4,489,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0164,414,512 - 4,433,990 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,782,025 - 3,799,625 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1163,782,022 - 3,799,623 (+)NCBI
Celera163,644,605 - 3,665,720 (+)NCBICelera
Cytogenetic Map16p16NCBI
Wnt5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554305,304,745 - 5,325,684 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554305,304,817 - 5,325,684 (-)NCBIChiLan1.0ChiLan1.0
WNT5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2255,448,868 - 55,472,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1355,453,639 - 55,475,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0355,396,279 - 55,418,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1356,617,006 - 56,639,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl356,621,380 - 56,638,051 (-)Ensemblpanpan1.1panPan2
WNT5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12034,756,430 - 34,790,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2034,769,930 - 34,786,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2034,700,143 - 34,711,111 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02035,028,713 - 35,063,140 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2035,042,240 - 35,061,488 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12034,490,948 - 34,501,920 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02034,851,115 - 34,862,094 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02035,066,932 - 35,077,922 (+)NCBIUU_Cfam_GSD_1.0
WNT5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1337,344,699 - 37,367,207 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11337,344,684 - 37,367,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21340,872,351 - 40,892,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12216,809,454 - 16,836,815 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2216,809,451 - 16,825,048 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041150,043,734 - 150,071,018 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248221,825,238 - 1,841,288 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248221,824,378 - 1,843,599 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000020758   ⟹   ENSSTOP00000020681
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364736,034,174 - 6,044,931 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000040936   ⟹   ENSSTOP00000028976
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364736,029,976 - 6,052,159 (-)Ensembl
RefSeq Acc Id: XM_013362082   ⟹   XP_013217536
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118172,893,045 - 172,913,645 (-)NCBI
SpeTri2.0NW_0049364736,031,627 - 6,052,211 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040289752   ⟹   XP_040145686
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118172,893,045 - 172,906,753 (-)NCBI
RefSeq Acc Id: XM_040289753   ⟹   XP_040145687
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118172,893,045 - 172,913,645 (-)NCBI
Protein Sequences
Protein RefSeqs XP_013217536 (Get FASTA)   NCBI Sequence Viewer  
  XP_040145686 (Get FASTA)   NCBI Sequence Viewer  
  XP_040145687 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000020681.2
  ENSSTOP00000028976.1
GenBank Protein KAG3279374 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013217536   ⟸   XM_013362082
- Peptide Label: isoform X1
- UniProtKB: A0A287D633 (UniProtKB/TrEMBL),   I3N8I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040145687   ⟸   XM_040289753
- Peptide Label: isoform X2
- UniProtKB: I3N8I5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040145686   ⟸   XM_040289752
- Peptide Label: isoform X2
- UniProtKB: I3N8I5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000028976   ⟸   ENSSTOT00000040936
Ensembl Acc Id: ENSSTOP00000020681   ⟸   ENSSTOT00000020758


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025090 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020758.2 UniProtKB/TrEMBL
  ENSSTOT00000040936.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene Wnt5a ENTREZGENE
PANTHER PTHR12027 UniProtKB/TrEMBL
  PTHR12027:SF33 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A287D633 ENTREZGENE, UniProtKB/TrEMBL
  I3N8I5 ENTREZGENE, UniProtKB/TrEMBL