WNT5A (Wnt family member 5A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: WNT5A (Wnt family member 5A) Sus scrofa
Analyze
Symbol: WNT5A
Name: Wnt family member 5A
RGD ID: 14195310
Description: ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); ameboidal-type cell migration (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); endometrial carcinoma (ortholog); Female Urogenital Diseases (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein Wnt-5a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1337,344,699 - 37,367,207 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11337,344,684 - 37,367,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21340,872,351 - 40,892,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (IEA)
activation of protein kinase B activity  (IEA,ISO)
ameboidal-type cell migration  (ISO)
anterior/posterior axis specification, embryo  (IEA)
anterior/posterior pattern specification  (ISO)
atrial septum development  (IEA)
axis elongation  (ISO)
axon guidance  (ISO)
axonogenesis  (ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (ISO)
cell migration  (ISO)
cellular protein localization  (IEA,ISO)
cellular response to calcium ion  (IEA)
cellular response to interferon-gamma  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to molecule of bacterial origin  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA)
cervix development  (IEA,ISO)
chemoattraction of serotonergic neuron axon  (IEA)
chemorepulsion of dopaminergic neuron axon  (IEA)
cochlea morphogenesis  (IEA,ISO)
convergent extension  (ISO)
convergent extension involved in axis elongation  (IEA,ISO)
convergent extension involved in organogenesis  (IEA,ISO)
determination of left/right symmetry  (ISO)
development of primary male sexual characteristics  (ISO)
digestive tract morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (ISO)
embryonic skeletal system development  (IEA)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
epithelial to mesenchymal transition  (ISO)
establishment of epithelial cell apical/basal polarity  (IEA,ISO)
establishment of planar polarity  (IEA,ISO)
estrous cycle  (ISO)
face development  (IEA)
genitalia development  (ISO)
heart looping  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
hindgut morphogenesis  (IEA,ISO)
hypophysis morphogenesis  (IEA,ISO)
inner ear morphogenesis  (ISO)
JNK cascade  (IEA,ISO)
keratinocyte differentiation  (IEA)
kidney development  (IEA,ISO)
lateral sprouting involved in mammary gland duct morphogenesis  (IEA,ISO)
limb morphogenesis  (ISO)
lung alveolus development  (ISO)
lung development  (IEA,ISO)
male gonad development  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
melanocyte proliferation  (IEA)
mesenchymal-epithelial cell signaling  (IEA,ISO)
mesodermal to mesenchymal transition involved in gastrulation  (IEA,ISO)
midbrain development  (ISO)
midbrain dopaminergic neuron differentiation  (ISO)
midgut development  (IEA,ISO)
morphogenesis of an epithelium  (ISO)
negative chemotaxis  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of axon extension involved in axon guidance  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell proliferation in midbrain  (IEA)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA)
negative regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of melanin biosynthetic process  (IEA)
negative regulation of mesenchymal cell proliferation  (IEA)
negative regulation of prostatic bud formation  (IEA,ISO)
negative regulation of synapse assembly  (IEA)
negative regulation of transcription, DNA-templated  (IEA)
neural tube closure  (ISO)
neural tube development  (ISO)
neurogenesis  (ISO)
neuron differentiation  (ISO)
neuron projection morphogenesis  (ISO)
non-canonical Wnt signaling pathway  (ISO)
non-canonical Wnt signaling pathway via JNK cascade  (IEA)
notochord morphogenesis  (IEA,ISO)
olfactory bulb interneuron development  (IEA)
paraxial mesoderm formation  (IEA,ISO)
pericardium morphogenesis  (ISO)
planar cell polarity pathway involved in axis elongation  (IEA,ISO)
planar cell polarity pathway involved in axon guidance  (IEA)
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in cardiac right atrium morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in gastrula mediolateral intercalation  (IEA,ISO)
planar cell polarity pathway involved in neural tube closure  (IEA,ISO)
planar cell polarity pathway involved in outflow tract morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in pericardium morphogenesis  (IEA,ISO)
planar cell polarity pathway involved in ventricular septum morphogenesis  (IEA,ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of cartilage development  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cell-cell adhesion mediated by cadherin  (IEA,ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-gamma production  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of JUN kinase activity  (IEA,ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of macrophage cytokine production  (IEA)
positive regulation of meiotic nuclear division  (IEA,ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of neuron death  (IEA)
positive regulation of neuron projection arborization  (IEA)
positive regulation of neuron projection development  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of non-canonical Wnt signaling pathway  (IEA)
positive regulation of ossification  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of protein binding  (IEA)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase C activity  (IEA)
positive regulation of protein kinase C signaling  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of response to cytokine stimulus  (ISO)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of thymocyte apoptotic process  (IEA,ISO)
positive regulation of timing of anagen  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon-mediated signaling pathway  (IEA)
post-anal tail morphogenesis  (IEA,ISO)
primary heart field specification  (IEA)
primitive streak formation  (IEA,ISO)
prostate gland development  (ISO)
protein phosphorylation  (IEA,ISO)
regulation of branching involved in mammary gland duct morphogenesis  (IEA,ISO)
regulation of cellular protein localization  (IEA)
regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
regulation of postsynapse organization  (IEA)
regulation of postsynaptic cytosolic calcium ion concentration  (IEA)
regulation of protein localization  (ISO)
regulation of synapse organization  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to hyperoxia  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to testosterone  (ISO)
secondary heart field specification  (IEA)
secondary palate development  (IEA)
somite development  (ISO)
somitogenesis  (IEA,ISO)
tube closure  (ISO)
type B pancreatic cell development  (IEA,ISO)
urinary bladder development  (IEA,ISO)
uterus development  (IEA,ISO)
vagina development  (IEA,ISO)
ventricular septum development  (ISO)
Wnt signaling pathway  (ISO)
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  (IEA)
Wnt signaling pathway, calcium modulating pathway  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)
wound healing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
WNT5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1337,344,699 - 37,367,207 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11337,344,684 - 37,367,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21340,872,351 - 40,892,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl355,465,715 - 55,490,539 (-)EnsemblGRCh38hg38GRCh38
GRCh38355,465,715 - 55,505,261 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37355,499,743 - 55,521,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36355,474,783 - 55,496,371 (-)NCBINCBI36hg18NCBI36
Build 34355,474,783 - 55,496,371NCBI
Celera355,465,957 - 55,488,272 (-)NCBI
Cytogenetic Map3p14.3NCBI
HuRef355,548,623 - 55,570,480 (-)NCBIHuRef
CHM1_1355,451,089 - 55,473,010 (-)NCBICHM1_1
Wnt5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391428,224,962 - 28,249,405 (+)NCBIGRCm39mm39
GRCm39 Ensembl1428,226,707 - 28,249,405 (+)Ensembl
GRCm381428,504,543 - 28,527,448 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1428,504,750 - 28,527,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv371429,318,659 - 29,338,620 (+)NCBIGRCm37mm9NCBIm37
MGSCv361427,332,339 - 27,352,300 (+)NCBImm8
Celera1424,754,276 - 24,774,180 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.8NCBI
Wnt5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2163,695,667 - 3,718,234 (+)NCBI
Rnor_6.0 Ensembl164,469,468 - 4,489,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0164,469,451 - 4,490,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0164,414,512 - 4,433,990 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,782,025 - 3,799,625 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1163,782,022 - 3,799,623 (+)NCBI
Celera163,644,605 - 3,665,720 (+)NCBICelera
Cytogenetic Map16p16NCBI
Wnt5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554305,304,745 - 5,325,684 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554305,304,817 - 5,325,684 (-)NCBIChiLan1.0ChiLan1.0
WNT5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1356,617,006 - 56,639,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl356,621,380 - 56,638,051 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0355,396,279 - 55,418,579 (-)NCBIMhudiblu_PPA_v0panPan3
WNT5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12034,756,430 - 34,790,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2034,769,930 - 34,786,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2034,700,143 - 34,711,111 (+)NCBI
ROS_Cfam_1.02035,028,713 - 35,063,140 (+)NCBI
UMICH_Zoey_3.12034,490,948 - 34,501,920 (+)NCBI
UNSW_CanFamBas_1.02034,851,115 - 34,862,094 (+)NCBI
UU_Cfam_GSD_1.02035,066,932 - 35,077,922 (+)NCBI
Wnt5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118172,893,045 - 172,913,645 (-)NCBI
SpeTri2.0NW_0049364736,031,627 - 6,052,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12216,809,454 - 16,836,815 (-)NCBI
ChlSab1.1 Ensembl2216,809,451 - 16,825,048 (-)Ensembl
Vero_WHO_p1.0NW_023666041150,043,734 - 150,071,018 (+)NCBI
Wnt5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248221,824,378 - 1,843,599 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 22 2 3 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000038472   ⟹   ENSSSCP00000037791
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1337,344,699 - 37,367,207 (-)Ensembl
RefSeq Acc Id: XM_005669658   ⟹   XP_005669715
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11337,344,684 - 37,361,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005669660   ⟹   XP_005669717
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11337,344,684 - 37,360,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013981798   ⟹   XP_013837252
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11337,344,684 - 37,367,215 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005669715 (Get FASTA)   NCBI Sequence Viewer  
  XP_005669717 (Get FASTA)   NCBI Sequence Viewer  
  XP_013837252 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013837252   ⟸   XM_013981798
- Peptide Label: isoform X2
- UniProtKB: A0A287A1J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005669715   ⟸   XM_005669658
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005669717   ⟸   XM_005669660
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000037791   ⟸   ENSSSCT00000038472


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070025133 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000037791 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070042458 UniProtKB/TrEMBL
  ENSSSCP00070042459 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000038472 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070050247 UniProtKB/TrEMBL
  ENSSSCT00070050248 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt5a UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene WNT5A ENTREZGENE
PANTHER PTHR12027 UniProtKB/TrEMBL
  PTHR12027:SF33 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A287A1J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VKW8_PIG UniProtKB/TrEMBL
  A0A4X1VLY9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94973 ENTREZGENE