RGD Reference Report - A transmembrane intracellular estrogen receptor mediates rapid cell signaling. - Rat Genome Database

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A transmembrane intracellular estrogen receptor mediates rapid cell signaling.

Authors: Revankar, CM  Cimino, DF  Sklar, LA  Arterburn, JB  Prossnitz, ER 
Citation: Revankar CM, etal., Science. 2005 Mar 11;307(5715):1625-30. Epub 2005 Feb 10.
RGD ID: 8553914
Pubmed: PMID:15705806   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1106943   (Journal Full-text)

The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control transcriptional activation through the classical nuclear estrogen receptors, it also initiates many rapid nongenomic signaling events. We found that of all G protein-coupled receptors characterized to date, GPR30 is uniquely localized to the endoplasmic reticulum, where it specifically binds estrogen and fluorescent estrogen derivatives. Activating GPR30 by estrogen resulted in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Esr1Ratnucleus located_inIDA PMID:15705806UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Esr1Ratsteroid binding enablesIDA PMID:15705806UniProt 
Esr2Ratsteroid binding enablesIDA PMID:15705806UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Esr1  (estrogen receptor 1)
Esr2  (estrogen receptor 2)


Additional Information