keratitis - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	keratitis	go back to main search page
Accession:	DOID:4677	browse the term
Definition:	A corneal disease that is characterized by inflammation of the cornea. (DO)
Synonyms:	exact_synonym:	keratitides
	primary_id:	MESH:D007634
	xref:	EFO:0009449; ICD10CM:H16; ICD9CM:370; NCI:C26805
For additional species annotation, visit the Alliance of Genome Resources.

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Rat (67) Mouse (66) Human (304) Chinchilla (59) Bonobo (63) Dog (64) Squirrel (58) Pig (64) Green Monkey (62) Naked Mole-rat (59) All
Genes (63)

keratitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083

G

gap junction protein beta 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954

G

interleukin 6

susceptibility

DNA:SNPs,haplotype:promoter:-174 G>C,−572 C/G(human)

NCBI chr 7:23,415,922...23,420,767

G

toll like receptor 2

treatment

associated with Aspergillosis:
associated with Eye Infections, Fungal;mRNA,protein:increased expression:cornea:
CTD Direct Evidence: marker/mechanism
associated with Onchocerciasis, Ocular;

PMID:17875630 PMID:18398706 PMID:21647173 PMID:23661603

RGD:7794840 RGD:8552816 RGD:8552914

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

G

toll like receptor 4

associated with Eye Infections,Fungal;DNA:SNP::rs10983755(human)
associated with Eye Infections, Fungal;mRNA,protein:increased expression:cornea:
associated with Eye Infections, Fungal; mRNA,protein:increased expression:macrophage:

PMID:18398706 PMID:19074808 PMID:19875664 PMID:24074256

RGD:7794779 RGD:7794785 RGD:7794845 RGD:8552914

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

vasoactive intestinal peptide

NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730

Acanthamoeba Keratitis

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

toll like receptor 4

mRNA,protein:increased expression:cornea

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

autosomal dominant keratitis

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

elongator acetyltransferase complex subunit 4

ClinVar Annotator: match by term: Autosomal dominant keratitis | ClinVar Annotator: match by term: Dominantly inherited keratitis | ClinVar Annotator: match by term: Keratitis, hereditary

PMID:25741868 PMID:28492532

NCBI chr11:31,473,439...31,754,446

G

paired box 6

ClinVar Annotator: match by term: Autosomal dominant keratitis | ClinVar Annotator: match by term: Dominantly inherited keratitis | ClinVar Annotator: match by term: Keratitis, hereditary

PMID:7627897 PMID:7668281 PMID:9727514 PMID:10234503 PMID:12634864 More...

NCBI chr11:31,753,190...31,782,225
Ensembl chr11:31,641,813...31,664,474

autosomal dominant keratitis-ichthyosis-deafness syndrome

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gap junction protein beta 2

ClinVar Annotator: match by term: KID syndrome | ClinVar Annotator: match by term: KID syndrome, autosomal dominant | ClinVar Annotator: match by term: Keratitis-ichthyosis-deafness syndrome, autosomal dominant

PMID:3 PMID:1218943 PMID:1511312 PMID:1693158 PMID:2706105 More...

NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954

Bacterial Keratitis

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 receptor type 1

associated with Serratia Infections;

Ensembl chr2A:103,193,131...103,230,005

G

lymphocyte antigen 96

associated with Serratia Infections;

NCBI chr 8:70,525,058...70,567,839
Ensembl chr 8:72,169,986...72,207,372

G

MYD88 innate immune signal transduction adaptor

associated with Staphylococcal Infections;
associated with Serratia Infections;

PMID:16926427 PMID:23033384

RGD:8552819 RGD:8662876

NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572

G

toll like receptor 2

associated with Pneumococcal Infections;
associated with Staphylococcal Infections;

PMID:16926427 PMID:23841825

RGD:8552819 RGD:8552886

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

G

toll like receptor 4

associated with Serratia Infections;
associated with Pneumococcal Infections;

PMID:23033384 PMID:23841825

RGD:8552886 RGD:8662876

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

toll like receptor 5

associated with Serratia Infections;

NCBI chr 1:198,787,046...198,819,537
Ensembl chr 1:203,798,767...203,801,343

Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

family with sequence similarity 83 member H

Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis

PMID:16961470 PMID:22212237 PMID:22253609 PMID:22339941 PMID:29284193 More...

NCBI chr 8:140,476,051...140,492,613
Ensembl chr 8:143,491,945...143,496,919

corneal neovascularization

term browser

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Object Name

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

mRNA, protein:increased expression:cornea

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

G

C-C motif chemokine receptor 2

PMID:12827053 PMID:19421039

RGD:8657360 RGD:9491750

NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312

G

C-C motif chemokine receptor 3

mRNA:increased expression:cornea

NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630

G

C-C motif chemokine receptor 5

NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379

G

CD36 molecule (CD36 blood group)

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

C-X3-C motif chemokine receptor 1

NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219

G

Fas cell surface death receptor

treatment

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

fibroblast growth factor 2

CTD Direct Evidence: marker/mechanism

PMID:9301478 PMID:11437330

NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942

G

fms related receptor tyrosine kinase 1

treatment

NCBI chr13:9,584,850...9,779,542

G

interleukin 17A

treatment

associated with Herpes Simplex

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 1 receptor antagonist

treatment

human protein in mouse model

PMID:10359324 PMID:12202509

RGD:8549790 RGD:8549796

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

integrin subunit alpha V

NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028

G

kinase insert domain receptor

treatment

PMID:18263815 PMID:21691137

RGD:8549714 RGD:8549755

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

mucin 4, cell surface associated

NCBI chr 3:193,050,895...193,114,931

G

platelet and endothelial cell adhesion molecule 1

PMID:21719569 PMID:22553751

RGD:6771213 RGD:6771229

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

peroxisome proliferator activated receptor gamma

treatment

NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060

G

serpin family F member 1

treatment

human gene in a rat model

NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568

G

TNF alpha induced protein 6

treatment

NCBI chr2B:38,669,652...38,692,037
Ensembl chr2B:155,933,842...155,956,382

G

vascular endothelial growth factor A

associated with Herpes Simplex;protein:increased expression:cornea:
CTD Direct Evidence: marker/mechanism

PMID:9301478 PMID:21325621 PMID:22467572

RGD:7483619 RGD:8547993

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

corneal ulcer

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PubMed Reference(s)

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G

interleukin 6

associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte:

NCBI chr 7:23,415,922...23,420,767

G

mucin 5AC, oligomeric mucus/gel-forming

associated with Hypersensitivity;mRNA:decreased expression:eye

NCBI chr11:1,191,223...1,234,373

G

nerve growth factor

CTD Direct Evidence: therapeutic

NCBI chr 1:87,223,597...87,276,759

G

serpin family F member 1

CTD Direct Evidence: therapeutic

NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568

G

tumor necrosis factor

associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte:

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

Fungal Keratitis

term browser

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Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-type lectin domain containing 7A

treatment

mRNA:increased expression:cornea

NCBI chr12:10,161,780...10,174,943
Ensembl chr12:10,410,384...10,425,452

G

toll like receptor 4

associated with Aspergillosis

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

triggering receptor expressed on myeloid cells 1

treatment

mRNA:increased expression:cornea

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

G

thymic stromal lymphopoietin

disease_progression

PMID:29550278 PMID:30853520

RGD:38549371 RGD:38549574

NCBI chr 5:106,440,136...106,446,849
Ensembl chr 5:112,242,490...112,250,130

herpes simplex virus keratitis

term browser

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PubMed Reference(s)

RGD Reference(s)

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G

apolipoprotein E

treatment

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

ATM serine/threonine kinase

ameliorates

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

C-C motif chemokine ligand 2

severity

associated with Herpes Simplex, Type 1

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

C-C motif chemokine ligand 20

NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225

G

C-C motif chemokine receptor 5

PMID:16476970 PMID:18798077

RGD:8551819 RGD:8551837

NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379

G

C-C motif chemokine receptor 6

NCBI chr 6:165,094,563...165,109,774
Ensembl chr 6:170,069,689...170,084,779

G

CD274 molecule

NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402

G

C-X-C motif chemokine receptor 3

NCBI chr X:60,880,759...60,883,355
Ensembl chr X:70,933,160...70,935,756

G

eukaryotic translation initiation factor 2 alpha kinase 2

treatment

NCBI chr2A:37,130,386...37,184,587
Ensembl chr2A:37,895,814...37,941,686

G

interferon beta 1

treatment

NCBI chr 9:20,884,742...20,886,317

G

interferon gamma

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

interleukin 10

treatment

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 1 beta

mRNA:increased expression:cornea

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor antagonist

treatment

human protein in a mouse model

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 21

treatment

PMID:21204603 PMID:29370719

RGD:127285376 RGD:127285545

NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915

G

interleukin 23 subunit alpha

mRNA;increased expression:trigeminal ganglion (mouse)

NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617

G

kinase insert domain receptor

treatment

protein:increased expression:cornea:

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

ribonuclease L

treatment

NCBI chr 1:158,092,346...158,108,026
Ensembl chr 1:161,741,645...161,760,045

G

signal transducer and activator of transcription 4

susceptibility

NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011

G

toll like receptor 2

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

G

toll like receptor 4

mRNA:increased expression:cornea:

PMID:17667620 PMID:17686871

RGD:7794851 RGD:8552970

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

tumor necrosis factor

mRNA:increased expression:cornea

PMID:10624423 PMID:12162877

RGD:7401196 RGD:8157603

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

Ichthyosiform Erythroderma, Corneal Involvement, Deafness

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adaptor related protein complex 1 subunit beta 1

ClinVar Annotator: match by term: Autosomal recessive keratitis-ichthyosis-deafness syndrome

PMID:25741868 PMID:31630788 PMID:31630791 PMID:32969855 PMID:33349978 More...

NCBI chr22:10,383,036...10,443,655
Ensembl chr22:28,189,831...28,285,007

Keratitis Fugax Hereditaria

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

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G

NLR family pyrin domain containing 3

ClinVar Annotator: match by term: KERATOENDOTHELIITIS FUGAX HEREDITARIA | ClinVar Annotator: match by term: Keratitis fugax hereditaria

PMID:49161 PMID:3604606 PMID:11687797 PMID:11992256 PMID:12355493 More...

NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216

Keratitis-Ichthyosis-Deafness Syndrome

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gap junction protein beta 2

ClinVar Annotator: match by term: Keratitis-Ichthyosis-Deafness Syndrome

PMID:22567369 PMID:25741868

NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954

keratoconjunctivitis

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mucin 16, cell surface associated

mRNA:increased expression:conjunctival epithelial cell

NCBI chr19:8,416,393...8,568,418

G

mucin 5AC, oligomeric mucus/gel-forming

mRNA:decreased expression:conjunctival epithelial cell

NCBI chr11:1,191,223...1,234,373

G

toll like receptor 2

protein:increased expression:conjnctival epithelium:

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

keratoconjunctivitis sicca

term browser

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Object Name

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Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

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G

C-C motif chemokine ligand 20

mRNA:increased expression:conjunctiva, cornea

NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225

G

C-C motif chemokine receptor 5

NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379

G

interleukin 6

associated with Sjogren's Syndrome;mRNA,protein:increased expression:conjunctiva:

NCBI chr 7:23,415,922...23,420,767

G

mucin 4, cell surface associated

NCBI chr 3:193,050,895...193,114,931

G

mucin 5AC, oligomeric mucus/gel-forming

NCBI chr11:1,191,223...1,234,373

G

neurturin

NCBI chr19:4,821,307...4,844,295

G

tumor necrosis factor

associated with Sjogren's Syndrome;mRNA:increased expression:conjunctiva:

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

Pseudomonas Aeruginosa Keratitis

term browser

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Object Name

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Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CCAAT enhancer binding protein beta

treatment

mRNA,protein:increased expression:cornea (mouse)

NCBI chr20:46,533,163...46,535,282

G

intercellular adhesion molecule 1

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

interleukin 10

treatment

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 18

NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371

G

interleukin 1 beta

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor antagonist

treatment

mRNA:increased expression:cornea (mouse)

PMID:9423885 PMID:11895986

RGD:7401195 RGD:8549805

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 6

NCBI chr 7:23,415,922...23,420,767

G

matrix metallopeptidase 9

treatment

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

toll like receptor 2

mRNA,protein:increased expression:cornea:

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

G

toll like receptor 4

mRNA,protein:increased expression:cornea:

PMID:17065506 PMID:20012880

RGD:7794775 RGD:8552969

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

thymic stromal lymphopoietin

severity

NCBI chr 5:106,440,136...106,446,849
Ensembl chr 5:112,242,490...112,250,130

Warburg-Cinotti Syndrome

term browser

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Object Name

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Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

discoidin domain receptor tyrosine kinase 2

ClinVar Annotator: match by term: Warburg-cinotti syndrome

PMID:9536098 PMID:17103436 PMID:17576681 PMID:23637089 PMID:25741868 More...

NCBI chr 1:138,048,730...138,200,426
Ensembl chr 1:141,932,158...141,990,766

Term paths to the root

Path 1
Term	Annotations
disease	15809
sensory system disease	7027
eye disease	3584
corneal disease	225
keratitis	63
Acanthamoeba Keratitis	1
Bacterial Keratitis +	15
Dermatoosteolysis Kirghizian Type	0
Fungal Keratitis	4
Keratitis Fugax Hereditaria	1
Keratitis-Ichthyosis-Deafness Syndrome +	2
Keratouveitis	0
autosomal dominant keratitis +	3
corneal neovascularization +	20
corneal ulcer +	5
deep keratitis +	0
filamentary keratitis	0
gonococcal keratitis	0
herpes simplex virus keratitis +	22
keratoconjunctivitis +	10
macular keratitis	0
photokeratitis	0
superficial keratitis +	0
Path 2
Term	Annotations
disease	15809
disease of anatomical entity	15486
nervous system disease	13579
Neurologic Manifestations	10044
sensory system disease	7027
eye disease	3584
corneal disease	225
keratitis	63
Acanthamoeba Keratitis	1
Bacterial Keratitis +	15
Dermatoosteolysis Kirghizian Type	0
Fungal Keratitis	4
Keratitis Fugax Hereditaria	1
Keratitis-Ichthyosis-Deafness Syndrome +	2
Keratouveitis	0
autosomal dominant keratitis +	3
corneal neovascularization +	20
corneal ulcer +	5
deep keratitis +	0
filamentary keratitis	0
gonococcal keratitis	0
herpes simplex virus keratitis +	22
keratoconjunctivitis +	10
macular keratitis	0
photokeratitis	0
superficial keratitis +	0

paths to the root