RGD Reference Report - Inhibition of corneal neovascularization by genetic ablation of CCR2. - Rat Genome Database

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Inhibition of corneal neovascularization by genetic ablation of CCR2.

Authors: Ambati, BK  Joussen, AM  Kuziel, WA  Adamis, AP  Ambati, J 
Citation: Ambati BK, etal., Cornea. 2003 Jul;22(5):465-7.
RGD ID: 8657360
Pubmed: (View Article at PubMed) PMID:12827053

PURPOSE: To determine if genetic ablation of the chemokine receptor CCR2 (involved in leukocyte and endothelial chemotaxis) inhibits the development of corneal neovascularization. METHODS: Wild-type C57BL/6J mice, as well as species-specific counterparts with targeted homozygous disruption of the CCR2, underwent chemical and mechanical denudation of corneal and limbal epithelium. Corneas were harvested 2 weeks after injury. Neovascularization was quantified by CD31 immunostaining. RESULTS: The mean percentages of neovascularized corneal area in control mice and CCR2-deficient mice 2 weeks after denudation were 58.3% and 38.8% (P = 0.047), respectively. CONCLUSIONS: Development of corneal neovascularization is inhibited in CCR2-deficient mice.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Mus musculus)
Ccr2  (chemokine (C-C motif) receptor 2)

Genes (Homo sapiens)
CCR2  (C-C motif chemokine receptor 2)


Additional Information