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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:keratoconjunctivitis
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Accession:DOID:9368 term browser browse the term
Definition:Simultaneous inflammation of the cornea and conjunctiva.
Synonyms:exact_synonym: Keratoconjunctivitides
 primary_id: MESH:D007637;   RDO:0005930
 xref: ICD10CM:H16.2;   ICD9CM:370.40;   NCI:C34744


show annotations for term's descendants           Sort by:
keratoconjunctivitis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Muc16 mucin 16, cell surface associated ISO mRNA:increased expression:conjunctival epithelial cell RGD PMID:18782111 RGD:7364735 NCBI chr 8:16,164,531...16,323,126 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:decreased expression:conjunctival epithelial cell RGD PMID:18782111 RGD:7364735 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:increased expression:conjnctival epithelium: RGD PMID:15875531 RGD:8552813 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fam83h family with sequence similarity 83, member H ISO Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis OMIA PMID:16961470 PMID:22212237 PMID:22253609 PMID:22339941 PMID:29284193 More... NCBI chr 7:107,716,431...107,724,619
Ensembl chr 7:107,716,431...107,728,672 		JBrowse link
keratoconjunctivitis sicca term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 ISO mRNA:increased expression:conjunctiva, cornea RGD PMID:20007286 RGD:7483613 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO RGD PMID:16159632 RGD:8549757 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Il6 interleukin 6 ISO associated with Sjogren's Syndrome;mRNA,protein:increased expression:conjunctiva: RGD PMID:10487957 RGD:7829756 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Muc4 mucin 4, cell surface associated ISO RGD PMID:14507865 RGD:7349377 NCBI chr11:68,008,245...68,053,242 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:14507865 RGD:7349377 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nrtn neurturin ISO RGD PMID:14507865 RGD:7349377 NCBI chr 9:1,581,860...1,587,835
Ensembl chr 9:1,581,975...1,583,102 		JBrowse link
G Tnf tumor necrosis factor ISO associated with Sjogren's Syndrome;mRNA:increased expression:conjunctiva: RGD PMID:10487957 RGD:7829756 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19055
    sensory system disease 7248
      eye disease 3728
        corneal disease 237
          keratitis 67
            keratoconjunctivitis 10
              Infectious Keratoconjunctivitis 0
              exposure keratitis 0
              keratoconjunctivitis sicca + 8
              neurotrophic keratoconjunctivitis 0
              phlyctenulosis 0
              punctate epithelial keratoconjunctivitis 0
              shipyard eye 0
Path 2
Term Annotations click to browse term
  disease 19055
    Pathological Conditions, Signs and Symptoms 13534
      Signs and Symptoms 11086
        Neurologic Manifestations 10337
          sensory system disease 7248
            eye disease 3728
              corneal disease 237
                keratitis 67
                  keratoconjunctivitis 10
                    Infectious Keratoconjunctivitis 0
                    exposure keratitis 0
                    keratoconjunctivitis sicca + 8
                    neurotrophic keratoconjunctivitis 0
                    phlyctenulosis 0
                    punctate epithelial keratoconjunctivitis 0
                    shipyard eye 0
paths to the root