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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indole-3-carboxylic acid
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Accession:CHEBI:24809 term browser browse the term
Definition:An indole-3-carboxylic acid carrying a carboxy group at position 3.
Synonyms:related_synonym: 1H-INDOLE-3-CARBOXYLIC ACID;   Formula=C9H7NO2;   InChI=1S/C9H7NO2/c11-9(12)7-5-10-8-4-2-1-3-6(7)8/h1-5,10H,(H,11,12);   InChIKey=KMAKOBLIOCQGJP-UHFFFAOYSA-N;   SMILES=OC(=O)c1c[nH]c2ccccc12
 alt_id: CHEBI:49657
 xref: Beilstein:129435;   CAS:771-50-6;   Gmelin:1875411;   HMDB:HMDB0003320
 xref_mesh: MESH:C012382
 xref: PDBeChem:ICO;   PMID:1262308;   PMID:13905029;   PMID:16664264;   PMID:23116603;   PMID:4844607;   Reaxys:129435
 cyclic_relationship: is_conjugate_acid_of CHEBI:62448


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indole-3-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of indole-3-carboxylic acid CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
tropisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein] CTD PMID:23285267 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein] CTD PMID:23285267 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein] CTD PMID:23285267 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP tropisetron results in increased expression of HMOX1 protein
SB 203580 inhibits the reaction [tropisetron results in increased expression of HMOX1 protein]
CTD PMID:23285267 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein] CTD PMID:23285267 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:24374478 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] CTD PMID:24374478 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]
tropisetron results in decreased expression of IL6 protein
CTD PMID:23285267 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein]
tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
CTD PMID:23285267, PMID:25837923 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of TNF protein]; tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:23285267, PMID:24374478 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            prokaryotic metabolite 18356
              bacterial metabolite 18356
                indole-3-carboxylic acid 12
                  1H-indole-3-carboxylate ester + 0
                  3-indole carboxylic acid glucuronide 0
                  4-O-(1H-indol-3-ylcarbonyl)ascaroside + 0
                  5-(6-O-malonyl-beta-D-glucosyloxy)-indole-3-carboxylic acid 0
                  6-(D-glucosyloxy)indole-3-carboxylic acid 0
                  D-glucosyl 6-hydroxyindole-3-carboxylate 0
                  D-glucosyl indole-3-carboxylate 0
                  methyl indole-3-carboxylate 0
                  tropisetron 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      benzopyrrole 9339
                                        indoles 9193
                                          indolyl carboxylic acid 3172
                                            indol-3-yl carboxylic acid 3171
                                              indole-3-carboxylic acid 12
                                                1H-indole-3-carboxylate ester + 0
                                                3-indole carboxylic acid glucuronide 0
                                                4-O-(1H-indol-3-ylcarbonyl)ascaroside + 0
                                                5-(6-O-malonyl-beta-D-glucosyloxy)-indole-3-carboxylic acid 0
                                                6-(D-glucosyloxy)indole-3-carboxylic acid 0
                                                D-glucosyl 6-hydroxyindole-3-carboxylate 0
                                                D-glucosyl indole-3-carboxylate 0
                                                methyl indole-3-carboxylate 0
                                                tropisetron 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.