|
G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of indole-3-carboxylic acid |
CTD |
PMID:24709313 |
|
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:38513929 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein] |
CTD |
PMID:38513929 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein] |
CTD |
PMID:38513929 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Casp12 |
caspase 12 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP12 protein] |
CTD |
PMID:26286524 |
|
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
|
|
G |
Casp3 |
caspase 3 |
increases expression multiple interactions |
ISO EXP |
Tropisetron results in increased expression of CASP3 protein modified form Paclitaxel inhibits the reaction [Tropisetron results in increased expression of CASP3 protein modified form] methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of CASP3 protein] |
CTD |
PMID:26286524 PMID:34654991 PMID:36504472 PMID:38513929 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased activity of CAT protein] |
CTD |
PMID:26286524 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions decreases expression |
EXP |
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein] |
CTD |
PMID:23285267 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
|
|
G |
Cst3 |
cystatin C |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in increased expression of CST3 protein] |
CTD |
PMID:33387473 |
|
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions decreases expression |
EXP |
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein] |
CTD |
PMID:23285267 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
|
|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions decreases expression |
EXP |
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein] |
CTD |
PMID:23285267 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP |
tropisetron results in increased expression of HMOX1 protein methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein]]; SB 203580 inhibits the reaction [Tropisetron results in increased expression of HMOX1 protein]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein] |
CTD |
PMID:23285267 PMID:26286524 PMID:38513929 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression |
EXP |
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein] |
CTD |
PMID:23285267 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of IL1B protein] |
CTD |
PMID:24374478 PMID:36504472 PMID:38513929 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il2 |
interleukin 2 |
multiple interactions |
EXP |
tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] |
CTD |
PMID:24374478 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
|
|
G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
EXP |
chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of IL6 protein] tropisetron results in decreased expression of IL6 protein |
CTD |
PMID:23285267 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] |
CTD |
PMID:36504472 |
|
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:38513929 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Mir146a |
microRNA 146a |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] |
CTD |
PMID:36504472 |
|
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA] |
CTD |
PMID:33387473 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP9 mRNA] |
CTD |
PMID:33387473 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions decreases activity |
EXP ISO |
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein] tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein] |
CTD |
PMID:23285267 PMID:25837923 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein] |
CTD |
PMID:26286524 PMID:38513929 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
[Paclitaxel co-treated with Tropisetron] results in decreased expression of RELA protein methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of RELA protein] |
CTD |
PMID:34654991 PMID:36504472 PMID:38513929 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] |
CTD |
PMID:33387473 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] |
CTD |
PMID:36504472 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
EXP ISO |
chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of TNF protein]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein] tropisetron results in decreased expression of TNF protein tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:23285267 PMID:24374478 PMID:36504472 PMID:38513929 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in increased expression of TP53 protein] |
CTD |
PMID:33387473 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
EXP |
Tropisetron inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] |
CTD |
PMID:36504472 |
|
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
|
|