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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-amino-4,6-dinitrotoluene
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Accession:CHEBI:19452 term browser browse the term
Definition:An amino-nitrotoluene that is 4,6-dinitrotoluene substituted at position 2 by an amino group.
Synonyms:exact_synonym: 2-methyl-3,5-dinitroaniline
 related_synonym: 2,4-Dinitro-6-aminotoluene;   2-Adnt;   2-Methyl-3,5-dinitrobenzenamine;   3,5-Dinitro-o-toluidine;   Formula=C7H7N3O4;   InChI=1S/C7H7N3O4/c1-4-6(8)2-5(9(11)12)3-7(4)10(13)14/h2-3H,8H2,1H3;   InChIKey=IEEJAAUSLQCGJH-UHFFFAOYSA-N;   SMILES=Cc1c(N)cc(cc1[N+]([O-])=O)[N+]([O-])=O
 xref: Beilstein:2377515;   CAS:35572-78-2;   KEGG:C16395
 xref_mesh: MESH:C035208
 xref: MetaCyc:CPD-10450;   PMID:16059748;   PMID:17990167;   PMID:20219247;   PMID:23983501;   Reaxys:2377515


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2-amino-4,6-dinitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP-binding cassette, sub-family C member 3 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ABCC3 mRNA CTD PMID:21346803 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ALDH1A1 mRNA CTD PMID:21346803 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ALDH1B1 mRNA CTD PMID:21346803 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ALMS1 mRNA CTD PMID:21346803 NCBI chr 6:85,564,482...85,698,973
Ensembl chr 6:85,564,513...85,679,735 		JBrowse link
G Atad1 ATPase family, AAA domain containing 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ATAD1 mRNA CTD PMID:21346803 NCBI chr19:32,649,958...32,717,187
Ensembl chr19:32,649,038...32,717,186 		JBrowse link
G Bspry B-box and SPRY domain containing affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of BSPRY mRNA CTD PMID:21346803 NCBI chr 4:62,398,248...62,415,537
Ensembl chr 4:62,398,290...62,415,535 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of CDKN1A mRNA CTD PMID:21346803 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of CHCHD6 mRNA CTD PMID:21346803 NCBI chr 6:89,360,128...89,572,634
Ensembl chr 6:89,360,128...89,572,634 		JBrowse link
G Cryl1 crystallin, lambda 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of CRYL1 mRNA CTD PMID:21346803 NCBI chr14:57,512,491...57,635,940
Ensembl chr14:57,512,450...57,635,986 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of CYP1A1 mRNA CTD PMID:21346803 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of CYP1A2 mRNA CTD PMID:21346803 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Dusp13b dual specificity phosphatase 13B affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of DUSP13B mRNA CTD PMID:21346803 NCBI chr14:21,783,463...21,792,947
Ensembl chr14:21,783,462...21,792,947 		JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ENTPD5 mRNA CTD PMID:21346803 NCBI chr12:84,420,649...84,455,803
Ensembl chr12:84,420,631...84,455,803 		JBrowse link
G Evl Ena-vasodilator stimulated phosphoprotein affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of EVL mRNA CTD PMID:21346803 NCBI chr12:108,520,942...108,654,775
Ensembl chr12:108,520,979...108,654,775 		JBrowse link
G Glul glutamate-ammonia ligase affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of GLUL mRNA CTD PMID:21346803 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Gpr68 G protein-coupled receptor 68 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of GPR68 mRNA CTD PMID:21346803 NCBI chr12:100,842,941...100,874,457
Ensembl chr12:100,842,941...100,874,457 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of GSTM1 mRNA CTD PMID:21346803 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of GSTP1 mRNA CTD PMID:21346803 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of HSD17B2 mRNA CTD PMID:21346803 NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of HSP90AA1 mRNA CTD PMID:21346803 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of HSP90AB1 mRNA CTD PMID:21346803 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197 		JBrowse link
G Hspb1 heat shock protein 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of HSPB1 mRNA CTD PMID:21346803 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Nectin1 nectin cell adhesion molecule 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of NECTIN1 mRNA CTD PMID:21346803 NCBI chr 9:43,655,251...43,718,758
Ensembl chr 9:43,655,281...43,743,955 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of NEDD9 mRNA CTD PMID:21346803 NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of NQO1 mRNA CTD PMID:21346803 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of NR1D1 mRNA CTD PMID:21346803 NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159 		JBrowse link
G Oat ornithine aminotransferase affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of OAT mRNA CTD PMID:21346803 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127 		JBrowse link
G Panx2 pannexin 2 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of PANX2 mRNA CTD PMID:21346803 NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770 		JBrowse link
G Pir pirin affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of PIR mRNA CTD PMID:21346803 NCBI chr  X:163,052,427...163,156,009
Ensembl chr  X:163,052,367...163,156,007 		JBrowse link
G Ropn1 ropporin, rhophilin associated protein 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ROPN1 mRNA CTD PMID:21346803 NCBI chr16:34,470,271...34,498,980
Ensembl chr16:34,470,291...34,498,988 		JBrowse link
G Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of SERPINA6 mRNA CTD PMID:21346803 NCBI chr12:103,612,889...103,623,477
Ensembl chr12:103,612,889...103,623,471 		JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of SGK2 mRNA CTD PMID:21346803 NCBI chr 2:162,829,249...162,856,059
Ensembl chr 2:162,829,250...162,856,047 		JBrowse link
G Slc35b4 solute carrier family 35, member B4 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of SLC35B4 mRNA CTD PMID:21346803 NCBI chr 6:34,132,810...34,153,921
Ensembl chr 6:34,130,315...34,154,046 		JBrowse link
G Sord sorbitol dehydrogenase affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of SORD mRNA CTD PMID:21346803 NCBI chr 2:122,065,320...122,095,818
Ensembl chr 2:122,065,230...122,095,821 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of STYXL1 mRNA CTD PMID:21346803 NCBI chr 5:135,776,074...135,807,277
Ensembl chr 5:135,776,074...135,807,239 		JBrowse link
G Tnr tenascin R affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of TNR mRNA CTD PMID:21346803 NCBI chr 1:159,351,170...159,759,299
Ensembl chr 1:159,351,339...159,759,299 		JBrowse link
G Trib1 tribbles pseudokinase 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of TRIB1 mRNA CTD PMID:21346803 NCBI chr15:59,520,503...59,528,948
Ensembl chr15:59,520,199...59,528,948 		JBrowse link
G Trim2 tripartite motif-containing 2 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of TRIM2 mRNA CTD PMID:21346803 NCBI chr 3:84,067,746...84,215,659
Ensembl chr 3:84,067,746...84,214,184 		JBrowse link
G Trp53 transformation related protein 53 increases expression
increases activity		 ISO 2-amino-4,6-dinitrotoluene results in increased expression of TP53 protein
2-amino-4,6-dinitrotoluene results in increased activity of TP53 protein		 CTD PMID:14577614 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tubb2b tubulin, beta 2B class IIB affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of TUBB2B mRNA CTD PMID:21346803 NCBI chr13:34,310,991...34,314,337
Ensembl chr13:34,310,731...34,314,449 		JBrowse link
G Tubb6 tubulin, beta 6 class V affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of TUBB6 mRNA CTD PMID:21346803 NCBI chr18:67,523,801...67,535,819
Ensembl chr18:67,523,787...67,535,819 		JBrowse link
G Tymp thymidine phosphorylase affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of TYMP mRNA CTD PMID:21346803 NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of UGT1A2 mRNA CTD PMID:21346803 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of UGT1A6 mRNA CTD PMID:21346803 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Wfdc3 WAP four-disulfide core domain 3 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of WFDC3 mRNA CTD PMID:21346803 NCBI chr 2:164,573,222...164,587,914
Ensembl chr 2:164,573,100...164,587,851 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ZAP70 mRNA CTD PMID:21346803 NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
G Zcwpw1 zinc finger, CW type with PWWP domain 1 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ZCWPW1 mRNA CTD PMID:21346803 NCBI chr 5:137,785,593...137,820,883
Ensembl chr 5:137,786,060...137,820,883 		JBrowse link
G Zdhhc6 zinc finger, DHHC domain containing 6 affects expression ISO 2-amino-4,6-dinitrotoluene affects the expression of ZDHHC6 mRNA CTD PMID:21346803 NCBI chr19:55,286,648...55,304,468
Ensembl chr19:55,259,723...55,304,464 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22192
    role 22177
      chemical role 21421
        explosive 4783
          2-amino-4,6-dinitrotoluene 48
Path 2
Term Annotations click to browse term
  CHEBI ontology 22192
    subatomic particle 22184
      composite particle 22184
        hadron 22184
          baryon 22184
            nucleon 22184
              atomic nucleus 22184
                atom 22184
                  main group element atom 22118
                    main group molecular entity 22118
                      s-block molecular entity 21717
                        hydrogen molecular entity 21635
                          hydrides 20775
                            inorganic hydride 18691
                              pnictogen hydride 18671
                                nitrogen hydride 18539
                                  azane 18447
                                    ammonia 18446
                                      organic amino compound 18446
                                        aromatic amine 15738
                                          anilines 14580
                                            substituted aniline 14210
                                              amino-nitrotoluene 569
                                                2-amino-4,6-dinitrotoluene 48
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