Slc35b4 (solute carrier family 35, member B4) - Rat Genome Database

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Gene: Slc35b4 (solute carrier family 35, member B4) Mus musculus
Analyze
Symbol: Slc35b4
Name: solute carrier family 35, member B4
RGD ID: 1615909
MGI Page MGI
Description: Predicted to enable UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity. Acts upstream of or within regulation of gluconeogenesis. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SLC35B4 (solute carrier family 35 member B4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930474D06Rik; AB041549; AW494345; expressed sequence AW494345; nucleotide sugar transporter SLC35B4; solute carrier family 35 member B4; UDP-xylose and UDP-N-acetylglucosamine transporter
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,132,810 - 34,153,921 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,130,315 - 34,154,046 (-)EnsemblGRCm39 Ensembl
GRCm38634,155,872 - 34,177,054 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,153,380 - 34,177,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,105,879 - 34,127,054 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,086,037 - 34,107,212 (-)NCBIMGSCv36mm8
Celera634,153,134 - 34,174,309 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map614.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15911612  
PMID:16141072   PMID:16141073   PMID:18799693   PMID:20798045   PMID:21267068   PMID:21507882   PMID:21862448   PMID:21873635   PMID:24194600   PMID:29867058   PMID:38355793  


Genomics

Comparative Map Data
Slc35b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,132,810 - 34,153,921 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,130,315 - 34,154,046 (-)EnsemblGRCm39 Ensembl
GRCm38634,155,872 - 34,177,054 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,153,380 - 34,177,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,105,879 - 34,127,054 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,086,037 - 34,107,212 (-)NCBIMGSCv36mm8
Celera634,153,134 - 34,174,309 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map614.75NCBI
SLC35B4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,289,332 - 134,320,338 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,289,332 - 134,316,930 (-)EnsemblGRCh38hg38GRCh38
GRCh377133,974,084 - 134,001,682 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,624,629 - 133,652,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 347133,431,346 - 133,459,058NCBI
Celera7128,711,529 - 128,739,279 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,275,903 - 128,303,642 (-)NCBIHuRef
CHM1_17133,908,420 - 133,936,166 (-)NCBICHM1_1
T2T-CHM13v2.07135,597,448 - 135,628,436 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,318,463 - 133,346,213 (-)NCBI
Slc35b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,744,188 - 63,766,200 (-)NCBIGRCr8
mRatBN7.2462,776,993 - 62,799,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,776,993 - 62,799,003 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,727,672 - 67,749,623 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,643,398 - 63,665,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,045,805 - 62,067,760 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,550,995 - 61,573,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,550,995 - 61,573,003 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,271,551 - 61,293,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,480,810 - 61,502,818 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1461,759,346 - 61,778,774 (-)NCBI
Celera457,829,712 - 57,851,719 (-)NCBICelera
Cytogenetic Map4q22NCBI
Slc35b4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541033,695,499 - 33,723,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541033,695,985 - 33,728,749 (+)NCBIChiLan1.0ChiLan1.0
SLC35B4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26171,107,228 - 171,135,051 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1723,117,483 - 23,145,282 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07126,249,622 - 126,277,395 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17138,756,637 - 138,784,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7138,761,768 - 138,783,720 (-)Ensemblpanpan1.1panPan2
SLC35B4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,120,901 - 3,166,622 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,120,934 - 3,149,926 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,777,771 - 2,806,756 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,850,661 - 2,896,364 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,850,651 - 2,884,651 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1143,054,439 - 3,083,441 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,799,262 - 2,828,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,945,417 - 2,974,427 (+)NCBIUU_Cfam_GSD_1.0
Slc35b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511821,322,350 - 21,344,634 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365791,454,916 - 1,477,232 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365791,454,951 - 1,474,035 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC35B4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1814,880,765 - 14,911,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11814,880,322 - 14,916,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21815,800,876 - 15,820,562 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC35B4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121102,909,444 - 102,935,021 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21102,913,084 - 102,935,141 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666042413,088 - 435,566 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc35b4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247832,079,154 - 2,109,287 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247832,079,324 - 2,110,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2428
Count of miRNA genes:834
Interacting mature miRNAs:1132
Transcripts:ENSMUST00000019143, ENSMUST00000138250, ENSMUST00000145857, ENSMUST00000146514
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11352717Obrq2a_mobesity resistance QTL 2a (mouse)63169434134847895Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse

Markers in Region
D6Mit310  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38634,162,506 - 34,162,627UniSTSGRCm38
MGSCv37634,112,506 - 34,112,627UniSTSGRCm37
Celera634,159,761 - 34,159,882UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.7UniSTS
Whitehead Genetic67.7UniSTS
Whitehead/MRC_RH6270.2UniSTS
Whitehead_YAC6 UniSTS
UniSTS:235405  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38634,155,776 - 34,155,975UniSTSGRCm38
MGSCv37634,105,776 - 34,105,975UniSTSGRCm37
Celera634,153,031 - 34,153,230UniSTS
Cytogenetic Map6B1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000019143   ⟹   ENSMUSP00000019143
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,130,315 - 34,154,046 (-)Ensembl
GRCm38.p6 Ensembl634,153,380 - 34,177,111 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138250   ⟹   ENSMUSP00000138721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,137,453 - 34,154,017 (-)Ensembl
GRCm38.p6 Ensembl634,160,518 - 34,177,082 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,135,020 - 34,153,905 (-)Ensembl
GRCm38.p6 Ensembl634,158,085 - 34,176,970 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146514
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,133,658 - 34,140,417 (-)Ensembl
GRCm38.p6 Ensembl634,156,723 - 34,163,482 (-)Ensembl
RefSeq Acc Id: NM_021435   ⟹   NP_067410
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39634,132,810 - 34,153,921 (-)NCBI
GRCm38634,155,879 - 34,177,054 (-)NCBI
MGSCv37634,105,879 - 34,127,054 (-)RGD
Celera634,153,134 - 34,174,309 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_184551
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39634,132,810 - 34,153,921 (-)NCBI
RefSeq Acc Id: NP_067410   ⟸   NM_021435
- UniProtKB: Q5U681 (UniProtKB/Swiss-Prot),   Q3TQU7 (UniProtKB/Swiss-Prot),   Q9JJF7 (UniProtKB/Swiss-Prot),   Q8CIA5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000138721   ⟸   ENSMUST00000138250
Ensembl Acc Id: ENSMUSP00000019143   ⟸   ENSMUST00000019143

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIA5-F1-model_v2 AlphaFold Q8CIA5 1-331 view protein structure

Promoters
RGD ID:6839992
Promoter ID:MM_KWN:45518
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC009BGW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36634,113,091 - 34,113,591 (-)MPROMDB
RGD ID:6839991
Promoter ID:MM_KWN:45519
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000035056,   OTTMUST00000035057,   OTTMUST00000035058
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36634,126,719 - 34,127,219 (-)MPROMDB
RGD ID:6889280
Promoter ID:EPDNEW_M8091
Type:initiation region
Name:Slc35b4_1
Description:Mus musculus solute carrier family 35, member B4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38634,176,971 - 34,177,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931249 AgrOrtholog
Ensembl Genes ENSMUSG00000018999 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019143 ENTREZGENE
  ENSMUST00000019143.9 UniProtKB/Swiss-Prot
  ENSMUST00000138250.2 UniProtKB/TrEMBL
InterPro UAA UniProtKB/Swiss-Prot
KEGG Report mmu:58246 UniProtKB/Swiss-Prot
MGD MGI:1931249 ENTREZGENE
NCBI Gene 58246 ENTREZGENE
PANTHER PTHR10778 UniProtKB/Swiss-Prot
  UDP-XYLOSE AND UDP-N-ACETYLGLUCOSAMINE TRANSPORTER UniProtKB/Swiss-Prot
Pfam UAA UniProtKB/Swiss-Prot
PhenoGen Slc35b4 PhenoGen
UniProt Q3TQU7 ENTREZGENE
  Q5U681 ENTREZGENE
  Q8CB74_MOUSE UniProtKB/TrEMBL
  Q8CIA5 ENTREZGENE
  Q9JJF7 ENTREZGENE
  S35B4_MOUSE UniProtKB/Swiss-Prot
  S4R2P0_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TQU7 UniProtKB/Swiss-Prot
  Q5U681 UniProtKB/Swiss-Prot
  Q9JJF7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Slc35b4  solute carrier family 35, member B4  AW494345  expressed sequence AW494345  Data merged from RGD:1607239 737654 PROVISIONAL