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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Geniposide
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Accession:CHEBI:5299 term browser browse the term
Definition:A terpene glycoside that has formula C17H24O10.
Synonyms:related_synonym: Formula=C17H24O10;   InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1;   InChIKey=IBFYXTRXDNAPMM-BVTMAQQCSA-N;   SMILES=COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]2[C@@H]1CC=C2CO
 xref: CAS:24512-63-8;   KEGG:C09781;   KNApSAcK:C00000320
 xref_mesh: MESH:C007835



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Geniposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO geniposide inhibits the reaction [Palmitic Acid results in decreased phosphorylation of AKT1 protein]
[geniposide co-treated with Hydrogen Peroxide] results in increased expression of AKT1 mRNA; geniposide inhibits the reaction [Hydrogen Peroxide results in decreased expression of AKT1 protein]
CTD PMID:22819839 PMID:37940031 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Bax BCL2-associated X protein increases expression ISO geniposide metabolite results in increased expression of BAX mRNA; geniposide metabolite results in increased expression of BAX protein CTD PMID:22245672 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO geniposide metabolite results in decreased expression of BCL2 mRNA; geniposide metabolite results in decreased expression of BCL2 protein
geniposide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA]; geniposide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]
CTD PMID:22245672 PMID:37940031 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
ISO geniposide metabolite results in increased expression of CASP3 protein
geniposide metabolite results in increased activity of CASP3 protein
geniposide inhibits the reaction [Palmitic Acid results in increased expression of and results in increased activity of CASP3 protein]
CTD PMID:22245672 PMID:22819839 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase multiple interactions EXP geniposide inhibits the reaction [Glycosides results in decreased activity of CAT protein]; geniposide inhibits the reaction [lei gong teng analog results in decreased activity of CAT protein] CTD PMID:26763404 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A decreases expression EXP geniposide results in decreased expression of CIDEA mRNA CTD PMID:34718029 NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP geniposide results in increased expression of CREB1 mRNA CTD PMID:37311497 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Dio2 deiodinase, iodothyronine, type II decreases expression EXP geniposide results in decreased expression of DIO2 mRNA CTD PMID:34718029 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO geniposide inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNMT1 mRNA]; geniposide inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNMT1 protein] CTD PMID:37940031 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 decreases expression EXP geniposide results in decreased expression of ELOVL3 mRNA CTD PMID:34718029 NCBI chr19:46,120,336...46,124,133
Ensembl chr19:46,120,336...46,124,133
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO geniposide inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]
[geniposide co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 protein; geniposide inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA]
CTD PMID:22819839 PMID:37940031 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP geniposide inhibits the reaction [Glycosides results in increased activity of GPT protein]; geniposide inhibits the reaction [lei gong teng analog results in increased activity of GPT protein] CTD PMID:26763404 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression ISO geniposide results in increased expression of GSTM1 mRNA; geniposide results in increased expression of GSTM1 protein CTD PMID:14646352 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression ISO geniposide results in increased expression of GSTM2 mRNA; geniposide results in increased expression of GSTM2 protein CTD PMID:14646352 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A increases expression EXP geniposide results in increased expression of HTR2A mRNA CTD PMID:37311497 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A increases expression EXP geniposide results in increased expression of HTR3A mRNA CTD PMID:37311497 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399
JBrowse link
G Il10 interleukin 10 multiple interactions EXP geniposide inhibits the reaction [Glycosides results in decreased expression of IL10 protein]; geniposide inhibits the reaction [lei gong teng analog results in decreased expression of IL10 protein] CTD PMID:26763404 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Insr insulin receptor increases expression EXP geniposide results in increased expression of INSR mRNA CTD PMID:37311497 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 increases expression EXP geniposide results in increased expression of KCNJ6 mRNA CTD PMID:37311497 NCBI chr16:94,545,839...94,798,719
Ensembl chr16:94,549,495...94,798,560
JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO geniposide inhibits the reaction [Hydrogen Peroxide results in decreased expression of MECP2 mRNA] CTD PMID:37940031 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Geniposide decreases expression of Nr1h4 mRNA in liver RGD PMID:28827769 RGD:15045609 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO geniposide inhibits the reaction [Palmitic Acid results in decreased expression of PDX1 protein] CTD PMID:22819839 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression EXP geniposide results in decreased expression of PPARGC1A mRNA CTD PMID:34718029 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prdm16 PR domain containing 16 decreases expression EXP geniposide results in decreased expression of PRDM16 mRNA; geniposide results in decreased expression of PRDM16 protein CTD PMID:34718029 NCBI chr 4:154,400,579...154,721,851
Ensembl chr 4:154,400,582...154,721,330
JBrowse link
G Pygl liver glycogen phosphorylase increases expression EXP Geniposide increased expression of PYGL in serum RGD PMID:25336395 RGD:21079733 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262
JBrowse link
G Six3os1 SIX homeobox 3, opposite strand 1 increases expression EXP geniposide results in increased expression of SIX3OS1 mRNA CTD PMID:37311497 NCBI chr17:85,909,360...85,925,824
Ensembl chr17:85,908,079...85,926,066
JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO Geniposide decreases expression of NTCP1 mRNA in rat liver RGD PMID:28827769 RGD:15045609 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
JBrowse link
G Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 increases expression EXP geniposide results in increased expression of TANC2 mRNA CTD PMID:37311497 NCBI chr11:105,480,458...105,820,130
Ensembl chr11:105,480,812...105,820,130
JBrowse link
G Tbx1 T-box 1 decreases expression EXP geniposide results in decreased expression of TBX1 mRNA CTD PMID:34718029 NCBI chr16:18,399,729...18,409,412
Ensembl chr16:18,399,729...18,409,421
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO [geniposide co-treated with Hydrogen Peroxide] results in decreased expression of TET1 mRNA; [geniposide co-treated with Hydrogen Peroxide] results in decreased expression of TET1 protein CTD PMID:37940031 NCBI chr10:62,640,349...62,723,242
Ensembl chr10:62,640,349...62,744,775
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO [geniposide co-treated with Hydrogen Peroxide] results in decreased expression of TET2 mRNA; [geniposide co-treated with Hydrogen Peroxide] results in decreased expression of TET2 protein CTD PMID:37940031 NCBI chr 3:133,169,438...133,250,882
Ensembl chr 3:133,169,440...133,250,900
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP geniposide inhibits the reaction [Glycosides results in decreased expression of TGFB1 mRNA]; geniposide inhibits the reaction [lei gong teng analog results in decreased expression of TGFB1 mRNA] CTD PMID:26763404 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tmem26 transmembrane protein 26 decreases expression EXP geniposide results in decreased expression of TMEM26 mRNA CTD PMID:34718029 NCBI chr10:68,559,576...68,618,485
Ensembl chr10:68,559,476...68,618,480
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP geniposide inhibits the reaction [Glycosides results in increased expression of TNF protein]; geniposide inhibits the reaction [lei gong teng analog results in increased expression of TNF protein] CTD PMID:26763404 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 decreases expression EXP geniposide results in decreased expression of TNFRSF9 mRNA CTD PMID:34718029 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO geniposide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA]; geniposide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] CTD PMID:37940031 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) decreases stability
decreases expression
multiple interactions
EXP geniposide results in decreased stability of UCP1 protein
geniposide results in decreased expression of UCP1 mRNA; geniposide results in decreased expression of UCP1 protein
Colforsin inhibits the reaction [geniposide results in decreased expression of UCP1 mRNA]; Colforsin inhibits the reaction [geniposide results in decreased expression of UCP1 protein]
CTD PMID:34718029 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22308
    chemical entity 22307
      atom 22302
        nonmetal atom 22132
          carbon atom 21924
            organic molecular entity 21924
              isoprenoid 14780
                terpenoid 14475
                  terpene glycoside 490
                    Geniposide 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 22308
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22183
                    p-block element atom 22183
                      carbon group element atom 21985
                        carbon atom 21924
                          organic molecular entity 21924
                            heteroorganic entity 21563
                              organochalcogen compound 21057
                                organooxygen compound 20905
                                  carbohydrates and carbohydrate derivatives 16059
                                    carbohydrate 16059
                                      carbohydrate derivative 14817
                                        glycosyl compound 13200
                                          glycoside 11900
                                            terpene glycoside 490
                                              Geniposide 39
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