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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amoxicillin trihydrate
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Accession:CHEBI:51254 term browser browse the term
Definition:A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.
Synonyms:exact_synonym: 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid trihydrate
 related_synonym: Amoxipen;   BRL 2333;   Clamoxyl;   Formula=C16H25N3O8S;   InChI=1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1;   InChIKey=MQXQVCLAUDMCEF-CWLIKTDRSA-N;   Larotid;   Moxaline;   Polymox;   Robamox;   SMILES=O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O;   Trimox;   Zimox
 xref: Beilstein:7507120;   CAS:61336-70-7;   DrugBank:DB01060;   KEGG:D00229


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Augmentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of ABCB11 mRNA CTD PMID:34767876 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of AKR1B10 mRNA CTD PMID:34767876 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Casp3 caspase 3 increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP3 protein CTD PMID:30273099 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP9 protein CTD PMID:30273099 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic increases secretion EXP Amoxicillin-Potassium Clavulanate Combination results in increased secretion of CYCS protein CTD PMID:30273099 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP27A1 mRNA CTD PMID:34767876 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP7A1 mRNA CTD PMID:34767876 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP8B1 mRNA CTD PMID:34767876 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of FGF19 mRNA CTD PMID:34767876 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of G6PD mRNA CTD PMID:34767876 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA CTD PMID:34767876 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLM mRNA CTD PMID:34767876 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GGT1 protein CTD PMID:34767876 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of GOT1 protein CTD PMID:30273099 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of GPT protein CTD PMID:30273099 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GPX2 mRNA CTD PMID:34767876 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GSR mRNA CTD PMID:34767876 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of ME1 mRNA CTD PMID:34767876 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of NR0B2 mRNA CTD PMID:34767876 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC10A1 mRNA CTD PMID:34767876 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc51a solute carrier family 51 member A decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC51A mRNA CTD PMID:34767876 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of SLC7A11 mRNA CTD PMID:34767876 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Tkt transketolase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of TKT mRNA CTD PMID:34767876 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of TXNRD1 mRNA CTD PMID:34767876 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          amoxicillin trihydrate 24
            Augmentin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              lactam 8390
                                                beta-lactam 830
                                                  beta-lactam antibiotic 815
                                                    penams 314
                                                      penicillanic acids 314
                                                        penicillanic acid 314
                                                          6-aminopenicillanic acid 314
                                                            penicillin 314
                                                              penicillin allergen 311
                                                                amoxicillin 45
                                                                  amoxicillin trihydrate 24
                                                                    Augmentin 24
paths to the root