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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amoxicillin
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Accession:CHEBI:2676 term browser browse the term
Definition:A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.
Synonyms:exact_synonym: 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid;   AMPC;   AX;   Amolin;   Amopenixin;   Amoxicillin anhydrous;   Clamoxyl;   Formula=C16H19N3O5S;   InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1;   InChIKey=LSQZJLSUYDQPKJ-NJBDSQKTSA-N;   Moxal;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O;   alpha-amino-p-hydroxybenzylpenicillin;   amoxicilina;   amoxicilline;   amoxicillinum;   amoxycilin;   amoxycillin;   p-hydroxyampicillin
 alt_id: CHEBI:133770
 xref: Beilstein:4274654;   CAS:26787-78-0;   DrugBank:DB01060;   Drug_Central:192;   HMDB:HMDB0015193;   KEGG:C06827;   KEGG:D07452;   LINCS:LSM-5654
 xref_mesh: MESH:D000658
 xref: PMID:10930630;   PMID:11431418;   PMID:11906332;   PMID:12569987;   PMID:12833570;   PMID:12850488;   PMID:16033609;   PMID:2083978;   PMID:24595455;   PMID:24631718;   PMID:24759068;   PMID:25998949;   PMID:27731424;   PMID:28987997;   PMID:29017833;   Patent:DE1942693;   Patent:GB1241844;   Patent:GB978178;   Patent:US3192198;   Reaxys:4274654;   VSDB:1741;   Wikipedia:Amoxicillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:51256



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amoxicillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Amoxicillin results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Aqp5 aquaporin 5 decreases expression EXP Amoxicillin results in decreased expression of AQP5 protein CTD PMID:30031112 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Amoxicillin results in decreased expression of CXCL10 mRNA CTD PMID:25091725 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO Amoxicillin results in increased expression of CYP11B2 CTD PMID:17822730 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Amoxicillin results in increased expression of CYP19A1 CTD PMID:17822730 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases activity
ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]
Amoxicillin results in decreased activity of CYP2C8 protein
CTD PMID:26763401
G Gsr glutathione-disulfide reductase decreases activity ISO Amoxicillin results in decreased activity of GSR protein CTD PMID:32196862 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Amoxicillin results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Amoxicillin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Amoxicillin results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        aetiopathogenetic role 19027
          allergen 17254
            penicillin 262
              amoxicillin 10
                amoxicillanyl group 0
                amoxicillin diketopiperazine 0
                amoxicillin trihydrate + 0
                amoxicilloyl group + 0
                amoxicilloyl polylysine 0
                amoxicilloyl-L-lysine + 0
                amoxicilloyl-butylamine 0
                ampicillanyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                lactam 8308
                                                  beta-lactam 796
                                                    beta-lactam antibiotic 781
                                                      penams 262
                                                        penicillanic acids 262
                                                          penicillanic acid 262
                                                            6-aminopenicillanic acid 262
                                                              penicillin 262
                                                                penicillin allergen 259
                                                                  amoxicillin 10
                                                                    amoxicillanyl group 0
                                                                    amoxicillin diketopiperazine 0
                                                                    amoxicillin trihydrate + 0
                                                                    amoxicilloyl group + 0
                                                                    amoxicilloyl polylysine 0
                                                                    amoxicilloyl-L-lysine + 0
                                                                    amoxicilloyl-butylamine 0
                                                                    ampicillanyl group 0
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