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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzotriazoles
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Accession:CHEBI:48912 term browser browse the term


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4,5,6,7-TETRABROMOBENZOTRIAZOLE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC protein] CTD PMID:26301327 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased expression of BAX protein CTD PMID:16489027 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein CTD PMID:16489027 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein CTD PMID:16489027 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC protein]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of FOS mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of NR4A1 mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased phosphorylation of BRD4 protein] CTD PMID:26301327 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased phosphorylation of BRD4 protein] CTD PMID:26301327 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:16489027 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:16489027 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16489027 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]] CTD PMID:22317921 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased expression of DNM1L protein] CTD PMID:37156403 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Fgf14 fibroblast growth factor 14 multiple interactions EXP 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN2A protein]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN8A protein]; 4,5,6,7-tetrabromobenzotriazole results in decreased expression of and affects the localization of FGF14 protein CTD PMID:26917740 NCBI chr15:101,045,033...101,679,888
Ensembl chr15:101,045,036...101,679,900 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of FOS mRNA] CTD PMID:26301327 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Acrylamide results in decreased activity of IKZF1 protein] CTD PMID:20708675 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein] CTD PMID:37156403 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of NR4A1 mRNA] CTD PMID:26301327 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased expression of PINK1 protein] CTD PMID:37156403 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased expression of PRKN protein] CTD PMID:37156403 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 multiple interactions EXP 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN2A protein] CTD PMID:26917740 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 multiple interactions EXP 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN8A protein] CTD PMID:26917740 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292 		JBrowse link
G Slc39a7 solute carrier family 39 member 7 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]] CTD PMID:22317921 NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP9 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased expression of BAX protein CTD PMID:16489027 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects binding
multiple interactions		 EXP alizapride binds to DRD2 protein
alizapride binds to and results in decreased activity of DRD2 protein		 CTD PMID:2571179 PMID:2901473 PMID:8103596 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
benzotriazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP benzotriazole results in increased expression of GSTA2 mRNA CTD PMID:8951341 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP benzotriazole results in increased expression of GSTA3 mRNA CTD PMID:8951341 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP benzotriazole results in increased expression of GSTA5 mRNA CTD PMID:8951341 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP benzotriazole results in increased expression of GSTM1 mRNA CTD PMID:8951341 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
vorozole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects binding ISO vorozole analog binds to CYP19A1 protein CTD PMID:9720668 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO vorozole results in increased activity of CYP1A1 protein CTD PMID:16714371 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          nitrogen atom 18933
            nitrogen molecular entity 18933
              organonitrogen compound 18783
                organonitrogen heterocyclic compound 18126
                  benzotriazoles 29
                    1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol 0
                    1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole 0
                    1-Hydroxybenzotriazole 0
                    1-[(2,4-dichlorophenyl)methoxy]benzotriazole 0
                    1-[1-[[1-[(4-methylphenyl)methyl]-5-tetrazolyl]methyl]-4-piperidinyl]-5-(trifluoromethyl)benzotriazole 0
                    1-[[2-(1-benzotriazolyl)-1-oxoethyl]amino]-3-cyclohexylthiourea 0
                    1-propan-2-yl-5-benzotriazolecarboxylic acid 0
                    2-(1H-1,2,3-Benzotriazol-1-yl)-N'-(3,4,5-trimethoxybenzylidene)acetohydrazide 0
                    2-(1H-1,2,3-benzotriazol-1-yl)-N-(2,3-dihydro-1H-inden-2-yl)acetamide 0
                    2-[(6-chloro-1-benzotriazolyl)oxy]-N-(4-fluorophenyl)acetamide 0
                    2-[[5-(1-benzotriazolylmethyl)-1,3,4-oxadiazol-2-yl]thio]-N-[(4-fluorophenyl)methyl]-N-phenylacetamide 0
                    2-amino-5-(1-benzotriazolyl)-6-methyl-4-phenyl-4H-pyran-3-carbonitrile 0
                    3-(1-benzotriazolyl)-N'-[(3-methoxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]propanehydrazide 0
                    3-(1-benzotriazolylmethyl)-6-(2-phenylethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                    3-(1-benzotriazolylmethyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                    3-(1-benzotriazolylmethyl)-6-thiophen-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                    4,5,6,7-TETRABROMOBENZOTRIAZOLE 22
                    4-Methylbenzotriazole 0
                    5-(Trifluoromethyl)-1H-1,2,3-benzotriazole 0
                    5-fluoro-1-[1-[[1-(2-phenylethyl)-5-tetrazolyl]methyl]-4-piperidinyl]benzotriazole 0
                    5-methyl-1H-benzotriazole 0
                    6-Chloro-5-methyl-1H-1,2,3-benzotriazole 0
                    6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide 1
                    N-(4-\{[(1H-benzotriazol-1-yl)acetyl][(thiophen-3-yl)methyl]amino\}phenyl)propanamide 0
                    N-\{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl\}-2-methylpropanamide 0
                    [\{4-[(2R,4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-benzotriazol-1-yl)-5-phenylpent-4-en-1-yl]phenyl\}(difluoro)methyl]phosphonic acid 0
                    benzotriazole + 4
                    methyl 1-isopropyl-1H-1,2,3-benzotriazole-5-carboxylate 0
                    vorozole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      p-block molecular entity 19756
                        carbon group molecular entity 19705
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterobicyclic compound 17216
                                      benzotriazoles 29
                                        1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol 0
                                        1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole 0
                                        1-Hydroxybenzotriazole 0
                                        1-[(2,4-dichlorophenyl)methoxy]benzotriazole 0
                                        1-[1-[[1-[(4-methylphenyl)methyl]-5-tetrazolyl]methyl]-4-piperidinyl]-5-(trifluoromethyl)benzotriazole 0
                                        1-[[2-(1-benzotriazolyl)-1-oxoethyl]amino]-3-cyclohexylthiourea 0
                                        1-propan-2-yl-5-benzotriazolecarboxylic acid 0
                                        2-(1H-1,2,3-Benzotriazol-1-yl)-N'-(3,4,5-trimethoxybenzylidene)acetohydrazide 0
                                        2-(1H-1,2,3-benzotriazol-1-yl)-N-(2,3-dihydro-1H-inden-2-yl)acetamide 0
                                        2-[(6-chloro-1-benzotriazolyl)oxy]-N-(4-fluorophenyl)acetamide 0
                                        2-[[5-(1-benzotriazolylmethyl)-1,3,4-oxadiazol-2-yl]thio]-N-[(4-fluorophenyl)methyl]-N-phenylacetamide 0
                                        2-amino-5-(1-benzotriazolyl)-6-methyl-4-phenyl-4H-pyran-3-carbonitrile 0
                                        3-(1-benzotriazolyl)-N'-[(3-methoxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]propanehydrazide 0
                                        3-(1-benzotriazolylmethyl)-6-(2-phenylethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                                        3-(1-benzotriazolylmethyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                                        3-(1-benzotriazolylmethyl)-6-thiophen-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                                        4,5,6,7-TETRABROMOBENZOTRIAZOLE 22
                                        4-Methylbenzotriazole 0
                                        5-(Trifluoromethyl)-1H-1,2,3-benzotriazole 0
                                        5-fluoro-1-[1-[[1-(2-phenylethyl)-5-tetrazolyl]methyl]-4-piperidinyl]benzotriazole 0
                                        5-methyl-1H-benzotriazole 0
                                        6-Chloro-5-methyl-1H-1,2,3-benzotriazole 0
                                        6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide 1
                                        N-(4-\{[(1H-benzotriazol-1-yl)acetyl][(thiophen-3-yl)methyl]amino\}phenyl)propanamide 0
                                        N-\{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl\}-2-methylpropanamide 0
                                        [\{4-[(2R,4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-benzotriazol-1-yl)-5-phenylpent-4-en-1-yl]phenyl\}(difluoro)methyl]phosphonic acid 0
                                        benzotriazole + 4
                                        methyl 1-isopropyl-1H-1,2,3-benzotriazole-5-carboxylate 0
                                        vorozole 2
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