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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-Hydroxypyrene
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Accession:CHEBI:34093 term browser browse the term
Definition:A pyrene that has formula C16H10O.
Synonyms:related_synonym: 1,5-dihydropyren-1-ol;   1-Hydroxy pyrene;   1-Pyrenol;   Formula=C16H10O;   InChI=1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H;   InChIKey=BIJNHUAPTJVVNQ-UHFFFAOYSA-N;   Pyren-1-ol;   SMILES=Oc1ccc2ccc3cccc4ccc1c2c34
 xref: CAS:5315-79-7;   HMDB:HMDB0013139;   KEGG:C14519
 xref_mesh: MESH:C033146
 xref: PMID:15159317;   PMID:15247141;   PMID:22815468


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1-Hydroxypyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases secretion
multiple interactions		 ISO ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite]		 CTD PMID:24140465 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 decreases expression ISO 1-hydroxypyrene results in decreased expression of AIFM3 mRNA CTD PMID:21854004 NCBI chr16:17,307,418...17,325,349
Ensembl chr16:17,307,475...17,325,349 		JBrowse link
G Ar androgen receptor multiple interactions ISO 1-hydroxypyrene binds to and results in decreased activity of AR protein; 1-hydroxypyrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; 1-hydroxypyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 PMID:27436773 PMID:33049310 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arfgap2 ADP-ribosylation factor GTPase activating protein 2 decreases expression ISO 1-hydroxypyrene results in decreased expression of ARFGAP2 mRNA CTD PMID:21854004 NCBI chr 2:91,095,460...91,107,716
Ensembl chr 2:91,095,319...91,107,276 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO 1-hydroxypyrene results in decreased expression of ASXL2 mRNA CTD PMID:21854004 NCBI chr12:3,476,892...3,560,811
Ensembl chr12:3,476,857...3,556,852 		JBrowse link
G C3 complement component 3 increases expression ISO 1-hydroxypyrene results in increased expression of C3 mRNA CTD PMID:22989670 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cldn15 claudin 15 decreases expression ISO 1-hydroxypyrene results in decreased expression of CLDN15 mRNA CTD PMID:21854004 NCBI chr 5:136,996,723...137,004,699
Ensembl chr 5:136,995,470...137,004,712 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases secretion ISO CYP1A1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Dazap1 DAZ associated protein 1 decreases expression ISO 1-hydroxypyrene results in decreased expression of DAZAP1 mRNA CTD PMID:21854004 NCBI chr10:80,097,168...80,124,242
Ensembl chr10:80,097,320...80,124,242 		JBrowse link
G E4f1 E4F transcription factor 1 decreases expression ISO 1-hydroxypyrene results in decreased expression of E4F1 mRNA CTD PMID:21854004 NCBI chr17:24,662,752...24,674,366
Ensembl chr17:24,662,752...24,689,287 		JBrowse link
G Erp27 endoplasmic reticulum protein 27 decreases expression ISO 1-hydroxypyrene results in decreased expression of ERP27 mRNA CTD PMID:21854004 NCBI chr 6:136,884,312...136,899,465
Ensembl chr 6:136,884,309...136,899,178 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO 1-hydroxypyrene binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
affects binding		 ISO 1-hydroxypyrene binds to and results in increased activity of ESR2 protein; 1-hydroxypyrene inhibits the reaction [ESR2 protein binds to Estradiol]
ESR2 protein binds to 1-hydroxypyrene		 CTD PMID:22989670 PMID:33049310 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Faap100 Fanconi anemia core complex associated protein 100 decreases expression ISO 1-hydroxypyrene results in decreased expression of FAAP100 mRNA CTD PMID:21854004 NCBI chr11:120,260,388...120,269,572
Ensembl chr11:120,259,881...120,269,590 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in decreased expression of FOXP3 mRNA CTD PMID:30951957 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Fst follistatin multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of FST protein CTD PMID:31228248 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487 		JBrowse link
G Gimap6 GTPase, IMAP family member 6 increases expression ISO 1-hydroxypyrene results in increased expression of GIMAP6 mRNA CTD PMID:21854004 NCBI chr 6:48,678,517...48,685,178
Ensembl chr 6:48,678,516...48,685,159 		JBrowse link
G Gm34066 predicted gene, 34066 decreases expression ISO 1-hydroxypyrene results in decreased expression of C2ORF66 mRNA CTD PMID:21854004 NCBI chr 1:54,481,731...54,495,945
Ensembl chr 1:54,482,563...54,495,922 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases secretion ISO GSTM1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases secretion ISO GSTP1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Haghl hydroxyacylglutathione hydrolase-like decreases expression ISO 1-hydroxypyrene results in decreased expression of HAGHL mRNA CTD PMID:21854004 NCBI chr17:25,998,817...26,004,560
Ensembl chr17:25,998,817...26,004,647 		JBrowse link
G Hspb1 heat shock protein 1 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of HSPB1 protein CTD PMID:31228248 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Il16 interleukin 16 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of IL16 protein CTD PMID:31228248 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934 		JBrowse link
G Itsn2 intersectin 2 increases expression ISO 1-hydroxypyrene results in increased expression of ITSN2 mRNA CTD PMID:21854004 NCBI chr12:4,642,792...4,763,952
Ensembl chr12:4,642,638...4,763,962 		JBrowse link
G Jag1 jagged 1 decreases expression ISO 1-hydroxypyrene results in decreased expression of JAG1 mRNA CTD PMID:22989670 NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564 		JBrowse link
G Lrp12 low density lipoprotein-related protein 12 decreases expression ISO 1-hydroxypyrene results in decreased expression of LRP12 mRNA CTD PMID:21854004 NCBI chr15:39,733,985...39,807,417
Ensembl chr15:39,733,985...39,807,390 		JBrowse link
G Myo15b myosin XVB decreases expression ISO 1-hydroxypyrene results in decreased expression of MYO15B mRNA CTD PMID:21854004 NCBI chr11:115,749,002...115,783,443
Ensembl chr11:115,749,232...115,783,429 		JBrowse link
G Nipal4 NIPA-like domain containing 4 increases expression ISO 1-hydroxypyrene results in increased expression of NIPAL4 mRNA CTD PMID:21854004 NCBI chr11:46,038,982...46,057,186
Ensembl chr11:46,038,982...46,057,335 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO
EXP		 1-hydroxypyrene binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 1-hydroxypyrene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO 1-hydroxypyrene results in increased expression of NRIP1 mRNA CTD PMID:22989670 NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 1-hydroxypyrene inhibits the reaction [Progesterone binds to PGR protein]; [Progesterone co-treated with 1-hydroxypyrene] results in decreased expression of PGR mRNA CTD PMID:9144411 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Phf2 PHD finger protein 2 increases expression ISO 1-hydroxypyrene results in increased expression of PHF2 mRNA CTD PMID:21854004 NCBI chr13:48,955,226...49,024,361
Ensembl chr13:48,955,226...49,024,595 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP		 1-hydroxypyrene binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO 1-hydroxypyrene results in increased expression of PTGR1 mRNA CTD PMID:21854004 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119 		JBrowse link
G Slc12a7 solute carrier family 12, member 7 decreases expression ISO 1-hydroxypyrene results in decreased expression of SLC12A7 mRNA CTD PMID:21854004 NCBI chr13:73,881,172...73,964,873
Ensembl chr13:73,881,213...73,964,873 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 decreases expression ISO 1-hydroxypyrene results in decreased expression of SLC25A34 mRNA CTD PMID:21854004 NCBI chr 4:141,346,130...141,351,202
Ensembl chr 4:141,346,135...141,351,132 		JBrowse link
G Spns3 SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) decreases expression ISO 1-hydroxypyrene results in decreased expression of SPNS3 mRNA CTD PMID:21854004 NCBI chr11:72,388,979...72,441,334
Ensembl chr11:72,385,745...72,441,332 		JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 increases metabolic processing ISO SULT1A2 protein results in increased metabolism of 1-hydroxypyrene CTD PMID:24140465 NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604 		JBrowse link
G Sult1b1 sulfotransferase family 1B, member 1 increases metabolic processing ISO SULT1B1 protein results in increased metabolism of 1-hydroxypyrene CTD PMID:24140465 NCBI chr 5:87,661,186...87,686,054
Ensembl chr 5:87,661,198...87,686,054 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 decreases activity
multiple interactions
increases sulfation		 ISO 1-hydroxypyrene results in decreased activity of SULT1E1 protein
acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1E1 protein]		 CTD PMID:14570759 PMID:16914110 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 multiple interactions ISO Dimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein] CTD PMID:14570759 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in decreased expression of TGFB1 mRNA CTD PMID:30951957 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO 1-hydroxypyrene binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tmem234 transmembrane protein 234 decreases expression ISO 1-hydroxypyrene results in decreased expression of TMEM234 mRNA CTD PMID:21854004 NCBI chr 4:129,494,449...129,502,326
Ensembl chr 4:129,494,461...129,517,852 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:21164388 NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730 		JBrowse link
G Vmn1r237 vomeronasal 1 receptor 237 decreases expression ISO 1-hydroxypyrene results in decreased expression of VN1R4 mRNA CTD PMID:21854004 NCBI chr17:21,534,279...21,535,148
Ensembl chr17:21,532,127...21,535,174 		JBrowse link
G Zfp335 zinc finger protein 335 decreases expression ISO 1-hydroxypyrene results in decreased expression of ZNF335 mRNA CTD PMID:21854004 NCBI chr 2:164,733,802...164,756,034
Ensembl chr 2:164,733,802...164,753,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    chemical entity 22209
      group 22105
        polyatomic entity 22105
          molecule 21702
            cyclic compound 21286
              organic cyclic compound 21285
                organic polycyclic compound 17938
                  pyrenes 335
                    1-Hydroxypyrene 54
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      p-block molecular entity 22136
                        carbon group molecular entity 21936
                          organic molecular entity 21861
                            organic molecule 21678
                              organic cyclic compound 21285
                                organic polycyclic compound 17938
                                  pyrenes 335
                                    1-Hydroxypyrene 54
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