CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Augmentin
Accession: CHEBI:2677
browse the term
Definition: A mixture composed of amoxicillin trihydrate and potassium clavulanate; a broad-spectrum antibiotic. The potassium clavulanate component is particularly active against the clinically important plasmid-mediated beta-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins.
Synonyms: related_synonym: Amoxicillin / clavulanic acid; Amoxicillin and clavulanate potassium; Amoxicillin hydrate-potassium clavulanate mixt; Amoxicillin mixture with Clavulanate potassium; Amoxicillin-potassium clavulanate combination; Potassium clavulanate mixed with amoxicillin
xref: CAS:74469-00-4; KEGG:D00230
xref_mesh: MESH:D019980
xref: PMID:25544822; Reaxys:23956304
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of ABCB11 mRNA
CTD
PMID:34767876
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of AKR1B10 mRNA
CTD
PMID:34767876
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Casp3
caspase 3
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP3 protein
CTD
PMID:30273099
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP9 protein
CTD
PMID:30273099
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cycs
cytochrome c, somatic
increases secretion
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased secretion of CYCS protein
CTD
PMID:30273099
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP27A1 mRNA
CTD
PMID:34767876
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP7A1 mRNA
CTD
PMID:34767876
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP8B1 mRNA
CTD
PMID:34767876
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Fgf19
fibroblast growth factor 19
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of FGF19 mRNA
CTD
PMID:34767876
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
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G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of G6PD mRNA
CTD
PMID:34767876
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA
CTD
PMID:34767876
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLM mRNA
CTD
PMID:34767876
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Ggt1
gamma-glutamyltransferase 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GGT1 protein
CTD
PMID:34767876
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Got1
glutamic-oxaloacetic transaminase 1
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of GOT1 protein
CTD
PMID:30273099
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of GPT protein
CTD
PMID:30273099
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx2
glutathione peroxidase 2
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GPX2 mRNA
CTD
PMID:34767876
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Gsr
glutathione-disulfide reductase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GSR mRNA
CTD
PMID:34767876
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Me1
malic enzyme 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of ME1 mRNA
CTD
PMID:34767876
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of NR0B2 mRNA
CTD
PMID:34767876
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC10A1 mRNA
CTD
PMID:34767876
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc51a
solute carrier family 51 member A
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC51A mRNA
CTD
PMID:34767876
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of SLC7A11 mRNA
CTD
PMID:34767876
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Tkt
transketolase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of TKT mRNA
CTD
PMID:34767876
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of TXNRD1 mRNA
CTD
PMID:34767876
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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