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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydrogencarbonate
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Accession:CHEBI:17544 term browser browse the term
Definition:The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Synonyms:exact_synonym: hydrogen(trioxidocarbonate)(1-);   hydrogencarbonate(1-);   hydrogentrioxocarbonate(1-);   hydrogentrioxocarbonate(IV);   hydroxidodioxidocarbonate(1-)
 related_synonym: Acid carbonate;   BICARBONATE ION;   Formula=CHO3;   HCO3-;   InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1;   InChIKey=BVKZGUZCCUSVTD-UHFFFAOYSA-M;   SMILES=OC([O-])=O;   [CO2(OH)](-);   bicarbonate;   hydrogen carbonate
 alt_id: CHEBI:13363;   CHEBI:22863;   CHEBI:40961;   CHEBI:5589;   MESH:D001639
 xref: Beilstein:3903504;   CAS:71-52-3;   Gmelin:49249;   HMDB:HMDB0000595;   KEGG:C00288
 xref_mesh: MESH:D001639
 xref: MetaCyc:HCO3;   PDBeChem:BCT;   PMID:17215880;   PMID:17505962;   PMID:18439416;   PMID:28732801;   PMID:29150416;   PMID:29460248;   PMID:29466234;   PMID:4208463;   Wikipedia:Bicarbonate
 cyclic_relationship: is_conjugate_acid_of CHEBI:41609;   is_conjugate_base_of CHEBI:28976


show annotations for term's descendants           Sort by:
hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 increases expression ISO Bicarbonates results in increased expression of ADCY10 protein CTD PMID:15117409 NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [[Iron co-treated with Bicarbonates] results in increased abundance of Malondialdehyde] CTD PMID:16027354 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Car1 carbonic anhydrase 1 increases chemical synthesis ISO CA1 protein results in increased chemical synthesis of Bicarbonates CTD PMID:17826101 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 increases chemical synthesis ISO CA2 protein results in increased chemical synthesis of Bicarbonates CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car3 carbonic anhydrase 3 increases chemical synthesis ISO CA3 protein results in increased chemical synthesis of Bicarbonates CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Cftr CF transmembrane conductance regulator increases transport
decreases transport
decreases secretion
multiple interactions
affects transport
decreases activity		 ISO CFTR protein results in increased transport of Bicarbonates
CFTR protein mutant form results in decreased transport of Bicarbonates
CFTR protein mutant form results in decreased secretion of Bicarbonates
Glyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates]
[Bicarbonates co-treated with Glutathione co-treated with Ascorbic Acid] results in increased activity of CFTR protein; Cyclic AMP promotes the reaction [CFTR protein results in increased transport of Bicarbonates]
Bicarbonates results in decreased activity of CFTR protein		 CTD PMID:11786964 PMID:14679199 PMID:15286085 PMID:15480994 PMID:15650130 More... NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Edn3 endothelin 3 affects secretion EXP Bicarbonates affects the secretion of EDN3 protein CTD PMID:15949640 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in increased secretion of Bicarbonates CTD PMID:18499763 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] which results in increased secretion of Bicarbonates CTD PMID:18499763 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Slc26a3 solute carrier family 26 member 3 affects transport ISO SLC26A3 protein affects the transport of Bicarbonates CTD PMID:12651923 NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 multiple interactions
increases transport		 ISO Estradiol inhibits the reaction [SLC26A6 protein results in increased transport of Bicarbonates] CTD PMID:35500753 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778 		JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions ISO Bicarbonates affects the reaction [SLC39A8 protein results in increased uptake of Zinc]; Bicarbonates promotes the reaction [SLC39A8 protein results in increased uptake of Cadmium]; SLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates] CTD PMID:16638970 PMID:27956349 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129 		JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO
EXP		 Bicarbonates inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]
Nitric Oxide inhibits the reaction [SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]]; SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]
SLC4A2 protein affects the transport of [Chlorides co-treated with Bicarbonates]		 CTD PMID:9563070 PMID:11852051 PMID:12612912 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965 		JBrowse link
G Slc9a2 solute carrier family 9 member A2 affects transport EXP SLC9A2 protein affects the transport of Bicarbonates CTD PMID:11704563 NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 affects uptake
multiple interactions
affects transport		 EXP SLC9A3 protein affects the uptake of Bicarbonates
[3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride results in decreased activity of SLC9A3 protein] which results in increased secretion of Bicarbonates; [5-dimethylamiloride results in decreased activity of SLC9A3 protein] which results in increased secretion of Bicarbonates
SLC9A3 protein affects the transport of Bicarbonates		 CTD PMID:11704563 PMID:12427137 PMID:12881227 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide]; [Peroxynitrous Acid co-treated with Bicarbonates] results in decreased activity of SOD1 protein; [Peroxynitrous Acid co-treated with Bicarbonates] results in increased metabolism of SOD1 protein; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide] CTD PMID:11451436 PMID:19243126 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
sodium hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Sodium Bicarbonate results in increased expression of ABCC2 mRNA CTD PMID:29126803 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression EXP Sodium Bicarbonate results in decreased expression of ABCG2 mRNA CTD PMID:29126803 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Car2 carbonic anhydrase 2 decreases expression EXP Sodium Bicarbonate results in decreased expression of CAR2 mRNA CTD PMID:31569818 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Cat catalase multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in decreased activity of CAT protein CTD PMID:25559736 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10430982 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Sodium Bicarbonate affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA] CTD PMID:25559736 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA] CTD PMID:25559736 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC15A1 mRNA CTD PMID:29126803 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc22a24 solute carrier family 22, member 24 increases expression EXP Sodium Bicarbonate results in increased expression of SLC22A24 mRNA CTD PMID:29126803 NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC22A6 mRNA CTD PMID:29126803 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions EXP SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]; SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride] CTD PMID:21509381 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC4A1 mRNA CTD PMID:31569818 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases transport
decreases expression		 ISO
EXP		 SLC4A4 protein results in increased transport of Sodium Bicarbonate
Sodium Bicarbonate results in decreased expression of SLC4A4 mRNA		 CTD PMID:18614622 PMID:31569818 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] CTD PMID:10430982 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA] CTD PMID:25559736 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA] CTD PMID:25559736 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of VIM protein] CTD PMID:10430982 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          cofactor 16151
            hydrogencarbonate 32
              hydrogen ((13)C)carbonate 0
              potassium hydrogencarbonate 0
              sodium hydrogencarbonate 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoanion 54
                                    hydrogencarbonate 32
                                      hydrogen ((13)C)carbonate 0
                                      potassium hydrogencarbonate 0
                                      sodium hydrogencarbonate 18
paths to the root