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gossypetin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gossypetin
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Accession:CHEBI:16400 term browser browse the term
Definition:A hexahydroxyflavone having the hydroxy groups placed at the 3-, 3'-, 4'-, 5- 7- and 8-positions.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-chromen-4-one
 related_synonym: 3,3',4',5,7,8-Hexahydroxyflavone;   Articulatidin;   Equisporol;   Formula=C15H10O8;   InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H;   InChIKey=YRRAGUMVDQQZIY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O
 alt_id: CHEBI:11682;   CHEBI:1362;   CHEBI:19860;   CHEBI:38341
 xref: CAS:489-35-0;   KEGG:C04109;   KNApSAcK:C00004721;   LINCS:LSM-36971;   LIPID_MAPS_instance:LMPK12113231
 xref_mesh: MESH:C059922
 xref: MetaCyc:334578-HEXAHYDROXYFLAVONE;   PMID:19895818;   PMID:22953867;   PMID:2676226;   PMID:8424824;   Patent:JP55054883;   Patent:WO0103681;   Reaxys:332194;   Wikipedia:Gossypetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57759;   is_conjugate_acid_of CHEBI:77862

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gossypetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg12 autophagy related 12 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases response to substance		 ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein]
BECN1 protein results in increased susceptibility to gossypetin		 CTD PMID:25622137 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of CASP3 protein] CTD PMID:25622137 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO gossypetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein] CTD PMID:25622137 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 decreases activity
multiple interactions		 ISO gossypetin results in decreased activity of PARP1 protein
gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of PARP1 protein]		 CTD PMID:17884996 PMID:25622137 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 multiple interactions ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein] CTD PMID:25622137 NCBI chr18:30,390,441...30,481,179
Ensembl chr18:30,405,800...30,481,179 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects response to substance EXP PPARA protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma affects response to substance EXP PPARG protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 ISO gossypetin results in increased expression of PTEN protein
Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein]		 CTD PMID:25622137 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SQSTM1 protein] CTD PMID:25622137 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
gossypin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf1 activating transcription factor 1 decreases phosphorylation
multiple interactions		 ISO
EXP		 gossypin results in decreased phosphorylation of ATF1 protein
gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein]		 CTD PMID:30536456 NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125 		JBrowse link
G Aurka aurora kinase A multiple interactions ISO gossypin binds to and results in decreased activity of AURKA protein CTD PMID:30536456 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO gossypin results in decreased expression of BCL2L1 protein CTD PMID:30536456 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO gossypin results in increased cleavage of CASP3 protein CTD PMID:30536456 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO gossypin results in increased cleavage of CASP7 protein CTD PMID:30536456 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO gossypin results in increased cleavage of CASP9 protein CTD PMID:30536456 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; gossypin inhibits the reaction [Oleic Acid results in increased activity of CAT protein] CTD PMID:37148149 PMID:37696682 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO gossypin results in decreased expression of CCNA2 protein CTD PMID:30536456 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gossypin results in decreased expression of CCNB1 protein CTD PMID:30536456 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases phosphorylation ISO gossypin results in decreased phosphorylation of CDK1 protein CTD PMID:30536456 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein] CTD PMID:37148149 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein] CTD PMID:30536456 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein] CTD PMID:37148149 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein] CTD PMID:37148149 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein] CTD PMID:37148149 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A protein] CTD PMID:37148149 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein] CTD PMID:37148149 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL1B mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 protein] CTD PMID:37148149 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL5 protein] CTD PMID:37148149 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Jun jun proto-oncogene decreases phosphorylation ISO gossypin results in decreased phosphorylation of JUN protein CTD PMID:30536456 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:37148149 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] CTD PMID:37148149 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO gossypin results in increased cleavage of PARP1 protein CTD PMID:30536456 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:37148149 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase polypeptide 3 multiple interactions ISO gossypin binds to and results in decreased activity of RPS6KA3 protein CTD PMID:30536456 NCBI chr  X:158,038,652...158,151,240
Ensembl chr  X:157,993,303...158,151,240 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein] CTD PMID:37148149 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF protein] CTD PMID:37148149 PMID:37696682 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22340
    role 22326
      biological role 22325
        biochemical role 21550
          metabolite 21499
            eukaryotic metabolite 21361
              plant metabolite 19242
                gossypetin 39
                  2,3-dihydrogossypetin 0
                  3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                  gossypetin 8-rhamnoside 0
                  gossypin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 22340
    subatomic particle 22335
      composite particle 22335
        hadron 22335
          baryon 22335
            nucleon 22335
              atomic nucleus 22335
                atom 22335
                  main group element atom 22218
                    p-block element atom 22218
                      carbon group element atom 22020
                        carbon atom 21959
                          organic molecular entity 21959
                            organic molecule 21787
                              organic cyclic compound 21413
                                organic heterocyclic compound 20391
                                  oxacycle 18916
                                    benzopyran 12233
                                      1-benzopyran 11992
                                        flavonoid 7312
                                          anthoxanthin 4644
                                            flavones 4644
                                              hydroxyflavone 4620
                                                flavonols 4487
                                                  7-hydroxyflavonol 4419
                                                    gossypetin 39
                                                      2,3-dihydrogossypetin 0
                                                      3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                                                      gossypetin 8-rhamnoside 0
                                                      gossypin 29
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