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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:substance dependence
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Accession:DOID:9973 term browser browse the term
Definition:A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance. (DO)
Synonyms:exact_synonym: substance addiction
 xref: NCI:C35458


show annotations for term's descendants           Sort by:
substance dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 treatment IDA ketamine RGD PMID:27713001 RGD:401960089 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO protein:decreased expression: hippocampus (human) RGD PMID:27494187 RGD:401851061 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
alcohol dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 susceptibility ISO DNA:SNP:: (rs2856966) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide ISO ClinVar Annotator: match by term: Alcohol dependence
associated with other drug dependencies; DNA:SNPs:CDS: (rs904096)		 ClinVar
OMIM
RGD		 PMID:3397059 PMID:3758060 PMID:10090900 PMID:15863807 PMID:17718394 More... RGD:405650603 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO RGD PMID:20077761 RGD:401827938 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adra2a adrenoceptor alpha 2A susceptibility ISO
IEP		 DNA:SNP:promoter: C-1291G (rs1800544) (human)
associated with stress-related disorder; mRNA:decreased expression:hypothalamus (rat)		 RGD PMID:21070505 PMID:26121187 RGD:401976462, RGD:401976544 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Ago1 argonaute RISC component 1 susceptibility ISO DNA:SNP:intron:A>G(rs595961)(human) RGD PMID:25495208 RGD:401900681 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 susceptibility ISO DNA:SNP:promoter:A>C(rs4961280)(human) RGD PMID:25495208 RGD:401900681 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO ClinVar Annotator: match by term: Alcohol dependence
DNA:SNP: :1510G>A (human)		 ClinVar
RGD		 PMID:2987944 PMID:4065146 PMID:6650498 PMID:7180842 PMID:7593603 More... RGD:401827938, RGD:401827936 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Angpt1 angiopoietin 1 ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs10090742) RGD PMID:27151647 RGD:405650603 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 susceptibility ISO DNA:polymorphism:exon:
DNA:SNP,haplotype:exon:rs1800497(human)		 RGD PMID:28574012 PMID:23443985 RGD:401959222, RGD:401959307 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arrb2 arrestin, beta 2 IEP mRNA:decreased expression:nucleus accumbens RGD PMID:34919270 RGD:401938593 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B IEP RGD PMID:21309953 RGD:14700679 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IDA
IEP		 RGD PMID:34453945 PMID:32579730 RGD:401959604, RGD:401959610 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 susceptibility ISO DNA:SNP::(rs6486120) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bmal2 basic helix-loop-helix ARNT like 2 susceptibility ISO DNA:SNPs, haplotype:: (rs7958822,rs4964057) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 4:179,699,432...179,747,710
Ensembl chr 4:179,699,502...179,746,949 		JBrowse link
G Bptf bromodomain PHD finger transcription factor ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs11870068) RGD PMID:27151647 RGD:405650603 NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C IEP mRNA, protein:increased expression:amygdala, hippocampus (rat)
protein:increased expression:inferior colliculus (human)		 RGD PMID:27905406 PMID:25556199 RGD:152985537, RGD:152985539 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cdk20 cyclin-dependent kinase 20 susceptibility ISO DNA:SNP:: (rs560019) (human) RGD PMID:18438686 RGD:401851917 NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826 		JBrowse link
G Chat choline O-acetyltransferase ISO protein:decreased expression:hippocampus,septum,striatum RGD PMID:8436061 RGD:401976285 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit susceptibility ISO DNA:missense:exons:p.R37H,p.E363D(human) RGD PMID:24057674 RGD:405849397 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit susceptibility ISO DNA:missense:exons:multiple(human) RGD PMID:24057674 RGD:405849397 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility
sexual_dimorphism
onset
disease_progression		 ISO associated with Alzheimer's disease; DNA:SNP:cd: P.V158M G>A (rs4680) (human)
DNA:SNPs,haplotypes:: (rs165774,rs4680) (human)
DNA:SNPs,haplotype:exon 4: p.V158M (rs4680) (human)
DNA:SNP:cd: p.V158M (rs4680) (human)
DNA:SNP:cd: p.V158M (human)
associated with major depressive disorder; DNA:SNP:cd: p.V158M (human)
DNA:polymorphism:exon 4: p.V158M (rs4680)(human)
associated with schizophrenia; DNA:promoter:Hypermethylation
associated with Trauma and Stressor Related Disorders ; DNA:polymorphism:exon: p.V158M (human)		 RGD PMID:25491588 PMID:22208661 PMID:16499480 PMID:24390676 PMID:16648777 More... RGD:11073926, RGD:401959747, RGD:401959300, RGD:401940156, RGD:401940155, RGD:401940149, RGD:401940148, RGD:401940146, RGD:401940133, RGD:401940131, RGD:401940120, RGD:401940118 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cpe carboxypeptidase E ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs10517844)
DNA:SNP:CDS: (rs13706874) (human)		 RGD PMID:27151647 PMID:20201924 RGD:405650603, RGD:405650609 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO
IDA
IEP		 DNA:SNP:exon:rs35349697
mRNA,protein:decreased expression:hippocampus		 RGD PMID:24704376 PMID:21951632 PMID:32579730 PMID:34453945 PMID:37031608 RGD:401938627, RGD:401959743, RGD:401959610, RGD:401959604, RGD:401959603 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO protein:increased expression:brain RGD PMID:12354285 RGD:401901262 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IDA RGD PMID:9927612 RGD:405650696 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 IDA RGD PMID:9927612 RGD:405650696 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 IDA RGD PMID:9927612 RGD:405650696 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit susceptibility ISO DNA:SNP:3���-UTR:G>T(rs1640299)(human) RGD PMID:25495208 RGD:401900681 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242 		JBrowse link
G Drd1 dopamine receptor D1 IMP RGD PMID:17360123 RGD:405100958 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 onset
susceptibility		 ISO DNA:insertion, deletion:promoter:
DNA:SNP: :rs1800498(human)		 RGD PMID:23238469 PMID:36825486 RGD:401959213, RGD:401959301 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd4 dopamine receptor D4 no_association ISO DNA:repeats:exon: RGD PMID:9342196 RGD:401959738 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 susceptibility ISO
IEP		 associated with stress-related disorder;DNA:SNP:: (rs1360780) (human)
associated with stress-related disorder;mRNA:affects expression:ventral tegmental area,cingulate cortex, nucleus accumbens( rat)
DNA:SNPs:intron,3'utr: (rs1360780, rs3800373)		 RGD PMID:27527158 PMID:27709495 PMID:27709495 PMID:27527158 RGD:401976484, RGD:401976487, RGD:401976487, RGD:401976484 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fmn1 formin 1 ISO associated with other drug dependencies; DNA:SNPs:CDS: (rs3910705) RGD PMID:27151647 RGD:405650603 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IDA
IEP		 protein:increased expression:granular insular cortex, paraventricular nucleus of thalamus, prefrontal cortex RGD PMID:29926762 PMID:17723286 PMID:14574439 PMID:17360123 RGD:405100722, RGD:405295497, RGD:405101697, RGD:405100958 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit treatment IEP RGD PMID:20626732 RGD:401851075 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility
treatment		 ISO
IMP
HEP		 DNA:SNP, haplotype:intron: C>G (rs29220) (human)
DNA:SNP:Exon 11: T1974C (Human)
mRNA:decreased expression:hippocampus (rat)
DNA:SNP:intron: (rs29220) (human)
DNA:SNP:intron: (rs29253) (human)		 RGD PMID:26727527 PMID:36095322 PMID:36095322 PMID:10412185 PMID:22253714 More... RGD:11552767, RGD:401976442, RGD:401976442, RGD:401959601, RGD:401900163, RGD:401940102, RGD:401940100 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 HEP mRNA:decreased expression:hippocampus (rat) RGD PMID:22253714 RGD:401900163 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO ClinVar Annotator: match by term: Alcohol dependence ClinVar
OMIM		 PMID:25741868 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO
HEP		 DNA:SNPs, haplotype:introns:IVS9+99C>A, IVS10+3145A>G (rs211014, rs211013) (human)
mRNA:decreased expression:hippocampus (human)
mRNA:increased expression:hippocampus (rat)		 RGD PMID:15630072 PMID:22253714 PMID:22253714 RGD:402463959, RGD:401900163, RGD:401900163 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 susceptibility
onset		 ISO DNA:SNPs, haplotype:5'UTR,IVS:Rs3749034,Rs2270335,Rs10439259(human)
DNA:SNPs: haplotype:multiple:rs1978340(human)		 RGD PMID:17067345 PMID:19111404 RGD:401900127, RGD:401900129 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 susceptibility ISO DNA:SNP::-243A>G (rs2236418) RGD PMID:17034009 RGD:401900120 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment IMP
IDA
ISO		 protein:decreased expression:serum RGD PMID:15659598 PMID:19232578 PMID:20553781 PMID:24801661 RGD:405820207, RGD:405850246, RGD:405849399, RGD:405849388 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gemin4 gem (nuclear organelle) associated protein 4 susceptibility ISO DNA:SNP:Promoter:C>T(rs910924)(human) RGD PMID:25495208 RGD:401900681 NCBI chr10:61,062,420...61,073,529
Ensembl chr10:61,066,425...61,073,431
Ensembl chr10:61,066,425...61,073,431 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 IEP protein:increased activity:plasma,liver,intestine: RGD PMID:6113606 RGD:14701046 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ameliorates ISO RGD PMID:33955100 RGD:405649731 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A susceptibility
ameliorates		 ISO DNA:repeats:promoter:(GT)n
DNA:mutation:cds:A825W(mouse)		 RGD PMID:21507155 PMID:33052417 PMID:29953905 RGD:401938633, RGD:401938638, RGD:401938635 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grm8 glutamate metabotropic receptor 8 susceptibility ISO DNA:SNPs:intron 1: (rs886003, rs17862325) (human) RGD PMID:25978827 RGD:11070870 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO RGD PMID:29582627 RGD:14700988 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO mRNA:increased expression:Brodmann (1909) area 9
associated with nicotine dependence;DNA:SNPs:enhancer:multiple
DNA:SNP: :140G>C		 RGD PMID:22176604 PMID:23216389 PMID:19060480 RGD:401900608, RGD:405849412, RGD:401900293 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B susceptibility
onset
sexual_dimorphism
no_association		 ISO DNA:SNP:5'UTR:-161A>T (human)
DNA:SNP: :861G>C (human)
DNA:SNP: :861G>C(human)
DNA:SNP,haplotype:promoter:161A>T (human)
DNA:SNP:promoter:rs11568817 (human) 		RGD PMID:12022963 PMID:21906503 PMID:11104852 PMID:11827742 PMID:21172311 More... RGD:405650693, RGD:405847406, RGD:405847401, RGD:405818273, RGD:405650698, RGD:405650694 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A disease_progression
susceptibility
treatment
no_association		 ISO
IMP
IEP		 DNA:SNP: :102T>C (rs6313)
protein:decreased expression:agranular insular cortex, cingulate cortex, frontal cortex
DNA:SNP:promoter:-1438G>A (rs6311)		 OMIM
RGD		 PMID:23321485 PMID:8822536 PMID:15080502 PMID:19328219 PMID:19060480 More... RGD:401900291, RGD:401900739, RGD:401900737, RGD:401900304, RGD:401900293, RGD:401900297 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A exacerbates
treatment
susceptibility		 ISO
IEP		 mRNA:increased expression:peripheral blood mononuclear cell (human)
DNA:SNPs:enhancer, exon: (rs1150226, rs1176713) (human)
DNA:SNPs, haplotype:multiple (human)
mRNA:increased expression:prefrontal cortex (rat)
DNA:SNP:exon 1: (rs33940208) (human)		 RGD PMID:27144979 PMID:23897038 PMID:24590108 PMID:25722691 PMID:23757001 RGD:404976874, RGD:405096433, RGD:404976878, RGD:404976876, RGD:404976875 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Kcnb2 potassium voltage-gated channel subfamily B member 2 ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs2251898) RGD PMID:27151647 RGD:405650603 NCBI chr 5:3,567,012...4,028,564
Ensembl chr 5:3,569,685...4,028,599 		JBrowse link
G Lep leptin IDA
IEP		 DNA:hypermethylation:promoter
protein:decreased expression:serum		 RGD PMID:29912265 PMID:29912265 RGD:21201248, RGD:21201248 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment IDA RGD PMID:34453945 RGD:401959604 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA RGD PMID:34453945 RGD:401959604 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ngf nerve growth factor ISO
IEP		 protein:increased expression:serum
protein:decreased expression:sciatic nerve
protein:decreased expression:plasma		 RGD PMID:17434673 PMID:8733743 PMID:16737466 RGD:401965399, RGD:401976493, RGD:401965409 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor IEP protein:altered expression:brain,neuron RGD PMID:7609866 RGD:401976553 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Npy neuropeptide Y susceptibility ISO DNA:SNP:cd: p.L7P (rs16139) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 IEP mRNA:altered expression:central amygdaloid nucleus (rat) RGD PMID:28461696 RGD:401960064 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Nrm nurim ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs2269705) RGD PMID:27151647 RGD:405650603 NCBI chr20:2,888,321...2,892,804
Ensembl chr20:2,877,567...2,891,802 		JBrowse link
G Nrxn3 neurexin 3 susceptibility ISO DNA:SNP,haplotype:Chr14:rs8019381, rs760288|rs8019381|2rs2293847 (human) RGD PMID:17804423 RGD:405096431 NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044 		JBrowse link
G Nucb2 nucleobindin 2 IEP mRNA,protein:decreased expression:hippocampus RGD PMID:37031608 RGD:401959603 NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353 		JBrowse link
G Oprd1 opioid receptor, delta 1 ISO DNA:SNP,haplotype:intron 1 (rs2298896|rs421300), multiple GCAAT (human) RGD PMID:17622222 RGD:401976552 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 no_association ISO DNA:SNPs:intron:multiple
DNA:SNP,haplotype:multiple (multiple GGCTTCT) (human)
mRNA:increased expression:orbitofrontal cortex
DNA:SNP: :rs6473797 (human)		 RGD PMID:16924269 PMID:17622222 PMID:21955155 PMID:24035285 RGD:401850571, RGD:401976552, RGD:401850584, RGD:401850579 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 no_association
treatment
sexual_dimorphism		 ISO DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:SNP: :rs1799971 (human)		 RGD PMID:16679777 PMID:24035285 PMID:30748046 PMID:11424981 PMID:35992511 More... RGD:401827936, RGD:401850579, RGD:401831038, RGD:401827953, RGD:401827952, RGD:401827944, RGD:11097488, RGD:401827938, RGD:401827938 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pde4b phosphodiesterase 4B susceptibility ISO DNA:SNP:: (rs1937443) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pdyn prodynorphin no_association
disease_progression		 ISO DNA:SNP, hypermethylation:promoter:rs2235751 (human)
mRNA, protein:increased expression:dorsolateral prefrontal cortex, orbitofrontal cortex
DNA:SNP: :rs1997794 (human)
DNA:SNP, hypermethylation:dorsolateral prefrontal cortex:rs2281285 (human)
DNA:SNP: :rs2281285 (human)
DNA:SNPs: :multiple
DNA:SNPs, haplotypes:multiple		 RGD PMID:28336495 PMID:21955155 PMID:24035285 PMID:21521424 PMID:26502829 More... RGD:401850551, RGD:401850584, RGD:401850579, RGD:401850575, RGD:11535796, RGD:401850571, RGD:401850565, RGD:401850560 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pknox2 PBX/knotted 1 homeobox 2 ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs750338) RGD PMID:27151647 RGD:405650603 NCBI chr 8:36,600,633...36,863,131
Ensembl chr 8:36,600,636...36,790,940 		JBrowse link
G Pomc proopiomelanocortin no_association ISO DNA:SNP: :rs934778 (human) RGD PMID:24035285 RGD:401850579 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:11418230 RGD:401959332 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rgs6 regulator of G-protein signaling 6 ISO associated with other drug dependencies; DNA:SNPs:CDS: (rs11621871) RGD PMID:27151647 RGD:405650603 NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 ISS OMIM:103780 MouseDO NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 susceptibility ISO DNA:insertion:promoter:: (human) RGD PMID:26727527 RGD:11552767 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 susceptibility ISO DNA:SNPs,haplotypes:intron: (rs36020,rs36029) (human) RGD PMID:21070505 RGD:401976462 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 disease_progression ISO DNA:VNTR RGD PMID:18552399 RGD:401900298 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Tas2r118 taste receptor, type 2, member 118 ISO OMIM NCBI chr 4:52,449,208...52,450,107
Ensembl chr 4:52,449,208...52,450,107 		JBrowse link
G Tbx19 T-box transcription factor 19 susceptibility ISO DNA:SNP:: (rs1003502) (human) RGD PMID:18438686 RGD:401851917 NCBI chr13:77,450,848...77,484,475
Ensembl chr13:77,450,849...77,504,163 		JBrowse link
cannabis dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A susceptibility ISO DNA:SNP: :3435C>T (rs1045642) (human) RGD PMID:19625010 RGD:401901192 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Comt catechol-O-methyltransferase ISO DNA:hypermethylation:promoter RGD PMID:24902721 RGD:401940112 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Hcrt hypocretin neuropeptide precursor ISO mRNA:increased expression:blood (human) RGD PMID:22846875 RGD:401960066 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Nrg1 neuregulin 1 susceptibility ISO DNA:SNP: :rs17664708(human) RGD PMID:22520967 RGD:405115756 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
cocaine dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankk1 ankyrin repeat and kinase domain containing 1 treatment ISO DNA:SNP: :rs1800497(human) RGD PMID:23635803 RGD:401959203 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ISO protein:increased expression:dorsal striatum, shell of nucleus accumbens (mouse) RGD PMID:27567310 RGD:401901591 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO RGD PMID:14973246 RGD:401965389 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV no_association ISO DNA:SNP: :rs919334
DNA:SNPs: :rs1457115, rs9285875		 RGD PMID:19001277 PMID:19001277 RGD:401938643, RGD:401938643 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Ccser1 coiled-coil serine-rich protein 1 susceptibility ISO DNA:SNP:: (rs1381355) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit susceptibility ISO DNA:missense:exons:p.R37H,p.E363D(human) RGD PMID:24057674 RGD:405849397 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit susceptibility ISO DNA:missense:exons:multiple(human) RGD PMID:24057674 RGD:405849397 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO DNA:SNPs,haplotypes:exon: p.V158M (rs4680, rs737865, rs165688) (human) RGD PMID:18704099 RGD:401959302 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment
sexual_dimorphism
no_association		 IEP
IDA
ISO		 protein:increased phosphorylation:nucleus accumbens
protein:increased phosphorylation:nucleus accumbens, prefrontal cortex
DNA:SNPs: :rs10876469, rs2177000		 RGD PMID:27664298 PMID:25522720 PMID:23665060 PMID:19001277 RGD:401900166, RGD:401851063, RGD:401851078, RGD:401938643 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Drd2 dopamine receptor D2 sexual_dimorphism
treatment		 IMP
ISO		 female only;DNA:SNP: :rs2283265(human) RGD PMID:29454035 PMID:30367264 PMID:23635803 RGD:13506950, RGD:401959597, RGD:401959203 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Egr1 early growth response 1 treatment IEP RGD PMID:26674058 RGD:405100964 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment
severity		 IEP protein:increased expression:habenula
mRNA:increased expression:brain
protein:increased expression:brain		 RGD PMID:26674058 PMID:29139213 PMID:18488248 PMID:18310906 PMID:24633559 RGD:405100964, RGD:401900161, RGD:401959615, RGD:405101699, RGD:405100965 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit treatment
ameliorates		 IEP
ISO		 protein:increased expression:Nucleus Accumbens, Caudate Putamen (rat)
protein:increased expression:dorsal striatum, nucelus accumbens (mouse)
mRNA,protein:increased expression:Nucleus Accumbens, Caudate Putamen (rat)
protein:increased expression:Brain (rat)		 RGD PMID:25522720 PMID:27380261 PMID:20633205 PMID:27664298 PMID:22403532 More... RGD:401851063, RGD:401901287, RGD:401900126, RGD:401900166, RGD:401851084, RGD:401851078 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility ISO DNA:SNP:intron: C>G (rs29220) (human)
mRNA:decreased expression:hippocampus (human)		 RGD PMID:22253714 PMID:26727527 RGD:401900163, RGD:11552767 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO mRNA:decreased expression:hippocampus (human) RGD PMID:22253714 RGD:401900163 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 ISO mRNA:decreased expression:hippocampus RGD PMID:22253714 RGD:401900163 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 ISO mRNA:decreased expression:hippocampus RGD PMID:22253714 RGD:401900163 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment
exacerbates		 IMP
IEP
ISO		 protein:increased expression:nucleus accumbens (rat)
protein:increased expression, increased phosphorylation:hippocampal formation, postsynaptic density (mouse)
protein:increased expression:nucleus accumbens cell surface (rat)
protein:increased phosphorylation:prefrontal cortex, premotor cortex (rat)
protein:increased phosphorylation:hippocampal formation (mouse)
protein:increased expression:ventral tegmental area (rat)		 RGD PMID:18430032 PMID:22127928 PMID:16794574 PMID:29089442 PMID:16207873 More... RGD:405096666, RGD:405820210, RGD:405820206, RGD:405818277, RGD:405818274, RGD:405650670, RGD:405650586, RGD:405649734, RGD:405649733, RGD:405649730, RGD:405100712 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment ISO
IMP		 DNA:SNP: :rs6561333 RGD PMID:23241418 PMID:15849375 PMID:23336050 RGD:401900299, RGD:401900756, RGD:401900743 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IMP RGD PMID:23336050 RGD:401900743 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO DNA:SNPs, haplotype:exon, intron: (rs1985242, rs2276302, rs4938066) (human)
DSNA:SNP:intron:g.113985089A>G (rs897687) (human)		 RGD PMID:24590108 PMID:26227246 RGD:404976878, RGD:405096480 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Klhl5 kelch-like family member 5 susceptibility ISO DNA:SNP:: (rs1046655) (human) RGD PMID:18438686 RGD:401851917 NCBI chr14:43,144,254...43,206,192
Ensembl chr14:43,144,257...43,184,238 		JBrowse link
G Lrrc7 leucine rich repeat containing 7 susceptibility ISO DNA:SNP: (rs1938584) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 2:247,146,616...247,634,945
Ensembl chr 2:247,147,752...247,634,547 		JBrowse link
G Manea mannosidase, endo-alpha susceptibility ISO DNA:SNPs:multiple RGD PMID:19255376 RGD:401851915 NCBI chr 5:40,196,373...40,218,540
Ensembl chr 5:40,196,396...40,218,459 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA protein:increased phosphorylation:brain RGD PMID:23665060 RGD:401851078 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA protein:increased phosphorylation:brain RGD PMID:23665060 RGD:401851078 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ngf nerve growth factor ISO protein:decreased expression:serum RGD PMID:17715210 RGD:401976440 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Oprd1 opioid receptor, delta 1 susceptibility
treatment		 ISO DNA:SNP,haplotype:intron 1 (rs2298896|rs421300), multiple GCAAT (human)
DNA:SNPs, haplotype:intron 1 (rs2298896|rs421300) (human)
associated with alcohol use disorder; DNA:SNP:intron (rs678849) (human)
associated with opiate dependence;DNA:SNP:intron (rs678849) (human)
DNA:SNP:intron,cds (rs678849,rs2234918) (human)		 RGD PMID:17622222 PMID:24533225 PMID:27449273 PMID:33953123 PMID:22795689 RGD:401976552, RGD:402525443, RGD:402463960, RGD:402463937, RGD:401976559 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO DNA:SNPs:intron:rs6473797, rs10111937 RGD PMID:34843875 RGD:401851040 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO mRNA:increased expression:nucleus accumbens RGD PMID:29992335 RGD:401831041 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin susceptibility ISO DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human)
mRNA:increased expression:nucleus accumbens
mRNA:increased expression:caudate-putamen
DNA:VNTR:Promoter		 RGD PMID:18923396 PMID:22390687 PMID:23164614 PMID:16184603 RGD:401850550, RGD:401851043, RGD:401850589, RGD:401850583 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Per2 period circadian regulator 2 susceptibility ISO DNA:repeats:: RGD PMID:22832851 RGD:401976513 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:21806491 RGD:401794583 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Prl prolactin severity ISO protein:decreased expression:blood serum (human)
protein:increased expression:blood plasma (human)
protein:increased expression:blood serum (human)		 RGD PMID:16915581 PMID:2243892 PMID:15064918 RGD:401959377, RGD:401960099, RGD:401959381 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rabep2 rabaptin, RAB GTPase binding effector protein 2 IEP protein:increased expression:brain RGD PMID:9789813 RGD:405255653 NCBI chr 1:181,010,305...181,026,651
Ensembl chr 1:181,010,305...181,026,648 		JBrowse link
G Sirt1 sirtuin 1 IEP protein:increased expression:brain, nucleus accumbens (rat) RGD PMID:27664298 RGD:401900166 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 treatment IEP RGD PMID:27664298 RGD:401900166 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Tenm3 teneurin transmembrane protein 3 susceptibility ISO DNA:SNP:: (rs1514483) (human) RGD PMID:18438686 RGD:401851917 NCBI chr16:41,251,909...43,978,594
Ensembl chr16:41,252,182...43,978,594 		JBrowse link
drug dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A treatment ISO DNA:polymorphisms: :2677G>T, ���1236C>T (human) RGD PMID:24455721 RGD:401901193 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 ISO associated with alcohol dependence;DNA:haplotype:exons: RGD PMID:18828801 RGD:401959320 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO associated with Trauma and Stressor Related Disorders;DNA:polymorphism:exon: p.V158M (human) RGD PMID:31150143 RGD:401940120 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IEP ketamine RGD PMID:29476799 RGD:401938642 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 treatment ISO DNA:polymorphism: :785A>G (rs2279343), (human) RGD PMID:24455721 RGD:401901193 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Faah fatty acid amide hydrolase ISO ClinVar Annotator: match by term: Drug addiction, susceptibility to ClinVar PMID:12060782 PMID:15254019 PMID:16972078 PMID:23556448 PMID:25741868 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO associated with alcohol dependence;DNA:haplotype:exon: RGD PMID:18828801 RGD:401959320 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO DNA:SNP, haplotype:exon 1 (rs1799971) (human) RGD PMID:33402148 RGD:402528879 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Ttc12 tetratricopeptide repeat domain 12 ISO associated with alcohol dependence;DNA:haplotype:exon: RGD PMID:18828801 RGD:401959320 NCBI chr 8:49,799,916...49,847,940
Ensembl chr 8:49,799,920...49,847,087 		JBrowse link
Drug Overdose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A susceptibility ISO DNA:SNPs:exons :3435C>T (rs1045642), 1236C>T (rs1128503)(human) RGD PMID:23515680 RGD:401901187 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: therapeutic CTD PMID:8527259 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: therapeutic CTD PMID:11914425 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 susceptibility ISO DNA:SNPs:cds:rs3745274 (c.516G > T, Q172H), rs8192719 (21563 C > T) (human) RGD PMID:28184434 RGD:401901144 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 susceptibility ISO DNA:polymorphism: :CYP2D6*4(1846G>A)(human) RGD PMID:15349706 RGD:401901260 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
heroin dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:10900239 RGD:10046064 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A treatment ISO associated with methadone treatment;DNA:SNP:intron (rs1128503) (human) RGD PMID:29173032 RGD:401976557 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:15717844 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adra1a adrenoceptor alpha 1A susceptibility ISO DNA:SNP:exon 4: p.R347C (rs1048101) (human) RGD PMID:33577997 RGD:401940110 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member susceptibility ISO DNA:polymorphism: : RGD PMID:21723677 RGD:401959204 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 onset
susceptibility		 ISO DNA:SNPS:exon:rs17115439, rs7118900, rs1800497 (human)
DNA:SNPs:5'UTR,exon:rs877138, rs4938013(human)
DNA:SNP:exon:rs1800497(human)
DNA:SNPs, haplotypes:intron, 3'flanking:rs11214598, rs2859545(human)		 RGD PMID:28854834 PMID:23303482 PMID:23840506 PMID:29550268 RGD:401959202, RGD:401959304, RGD:401959223, RGD:401959205 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arrb2 arrestin, beta 2 treatment ISO DNA:polymorphism: :rs1045280(human)
associated with methadone treatment;DNA:SNP:intron (rs1045280) (human)		 RGD PMID:33783060 PMID:29173032 RGD:401901593, RGD:401976557 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased activity:blood plasma (human) RGD PMID:30707402 RGD:401960085 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum		 CTD
RGD		 PMID:17715210 PMID:17715210 RGD:401976440 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO DNA:SNP:intron:rs2350780 (human) RGD PMID:19500151 RGD:5509583 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Comt catechol-O-methyltransferase severity
onset
susceptibility		 ISO DNA:SNP:exon 5: (rs769224) (human)
DNA:SNP:cd: p.V158M (human)
DNA:SNP:: (rs737866) (Human)
DNA:SNP:-287A>G (human)
DNA:SNP:exon 1: (rs737866) (Human)
DNA:SNP:exon 4: (rs4680) p.V158M (human)		 RGD PMID:33577997 PMID:33544778 PMID:23155402 PMID:12476424 PMID:21857968 More... RGD:401940110, RGD:401959602, RGD:401959234, RGD:401940154, RGD:401940140, RGD:401940113 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA
ISO		 DNA:SNP:exon:rs35349697 RGD PMID:21362452 PMID:24704376 PMID:23062870 RGD:401901181, RGD:401938627, RGD:401901182 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 treatment ISO DNA:polymorphisms: :785A>G (rs2279343), 516G>T (rs3745274)(human) RGD PMID:21790905 RGD:11097675 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 treatment ISO DNA:SNP:exon:CYP2C19*2 (681G>A,rs4244285)(human)
DNA:SNPs::CYP2C19*2, CYP2C19*3(human)		 RGD PMID:24016178 PMID:24956251 RGD:401960868, RGD:401960881 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:28598964 RGD:13506959 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 susceptibility
onset		 ISO
IEP		 CTD Direct Evidence: marker/mechanism
DNA:SNP:intron:rs1079597(human)
DNA:SNPS:exon, intron:multiples(human)		 CTD
RGD		 PMID:11751029 PMID:23840506 PMID:28854834 PMID:28598964 RGD:401959223, RGD:401959202, RGD:13506959 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 IEP RGD PMID:28598964 RGD:13506959 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility
onset		 ISO DNA:SNPs:5promoter:rs1800955,rs936462(human)
DNA:SNP,methylation::rs3758653(human)
DNA:polymorphism:promoter:-521G>A(human)		 RGD PMID:23840506 PMID:34864042 PMID:18991844 RGD:401959223, RGD:401959595, RGD:401959594 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fas Fas cell surface death receptor IEP protein:increased expression:cerebral cortex (rat) RGD PMID:14530904 RGD:8686423 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 susceptibility ISO DNA:SNPs:intron,3'utr: (rs1360780,rs3800373) (human) RGD PMID:24845178 RGD:401976498 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ameliorates IDA RGD PMID:21362452 PMID:23062870 RGD:401901181, RGD:401901182 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility ISO DNA:SNP:intron: C>G (rs29220) (human) RGD PMID:26727527 RGD:11552767 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19833324 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO DNA:SNP:intron: (rs211014) (human) RGD PMID:17440936 RGD:402525444 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 treatment
susceptibility		 ISO DNA:SNPs, haplotype:multiple:
DNA:SNP,haplotype: :rs2058725(human)
DNA:SNPs,haplotypes:promoter,exon:rs1978340, rs3791878, rs11542313 (human)		 RGD PMID:31866536 PMID:19500151 PMID:22564729 RGD:401900128, RGD:5509583, RGD:401900156 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 susceptibility ISO DNA:SNP: ::rs8190646(human) RGD PMID:19500151 RGD:5509583 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO DNA:SNP: :rs2910709 RGD PMID:24022000 RGD:405849398 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment ISO
IEP		 mRNA:increased expression:ventral striatum (human) RGD PMID:27863698 PMID:19940171 RGD:405096665, RGD:4107717 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A susceptibility ISO DNA:repeats,SNPs,haplotype:introns:(GT)26, rs3219790,rs1102972,rs1650420,rs3104703 (human)
DNA:repeats: :(GT)26 (human)		 RGD PMID:23940648 PMID:25366762 RGD:401938628, RGD:401938629 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grm2 glutamate metabotropic receptor 2 IMP RGD PMID:30283001 RGD:38501063 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:30283001 RGD:38501063
G Hcrt hypocretin neuropeptide precursor treatment ISO RGD PMID:35984180 RGD:401960075 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO DSNA:SNPs:promoter, intron, CDS:g.113974819C>T, g.113985089A>G, g.113989703A>G (rs1150226, rs897687, rs1176713) (human)
DNA:SNPs, haplotype:multiple (human)		 RGD PMID:26227246 PMID:19500151 RGD:405096480, RGD:5509583 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO DNA:SNP: :rs2070995 (human) RGD PMID:20220551 RGD:6483055 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15717844 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Ngf nerve growth factor treatment ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum
DNA:SNP:intron:rs2239622		 CTD
RGD		 PMID:17715210 PMID:17715210 PMID:21358750 RGD:401976440, RGD:401965390 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 susceptibility ISO DNA:SNP, haplotype:intron: (rs4234955) (human)
DNA:SNP:intron: (rs4518200) (human)		 RGD PMID:29465008 PMID:24845178 RGD:402463944, RGD:401976498 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprd1 opioid receptor, delta 1 onset
treatment		 ISO DNA:SNP: :rs508448 (human)
associated with stress-related disorder;DNA:SNP:coding synonymous,intron (rs2234918, rs2236857) (human)
associated with methadone treatment;DNA:SNP:intron (rs529520) (human)
DNA:SNP, haplotype:intron 1 (multiple) (human)
DNA:SNP, haplotype:multiple (multiple) (human)
DNA:SNP:CDS:intron 1 (rs204047|rs797397) (human)		 RGD PMID:28692418 PMID:30171993 PMID:29173032 PMID:22500942 PMID:34031368 More... RGD:401831045, RGD:401977579, RGD:401976557, RGD:401976535, RGD:401976533, RGD:401976443 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment IMP
ISO		 DNA:SNP: :rs3802279, rs3802281, and rs963549 (human) RGD PMID:24725195 PMID:24305833 PMID:31940240 RGD:9831447, RGD:401850592, RGD:401827951 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 susceptibility
no_association
severity		 ISO CTD Direct Evidence: marker/mechanism
mRNA:splice variants:prefrontal cortex
DNA:SNPs, haplotypes: :multiple
DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:SNP, haplotype: :rs483481 (human)
DNA:SNPs, haplotypes: :rs696522, rs1381376, rs3778151 (human)		 CTD
RGD		 PMID:20201854 PMID:32506472 PMID:28692418 PMID:28976288 PMID:11424981 More... RGD:401831047, RGD:401831045, RGD:401831044, RGD:401827953, RGD:401827950, RGD:401827940 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin onset
susceptibility
no_association		 ISO DNA:repeat:promoter:rs35286251 (human)
DNA:VNTR, SNPs:rs1022563, rs2235749, rs910080 (human)
DNA:VNTR:promoter
DNA:SNPs, repeat:promoter:rs2281285, rs2235749, rs35286251 (human)
DNA:SNP: :rs910080 (human)
mRNA:decreased expression:periamygdaloid cortex		 RGD PMID:30936032 PMID:21382455 PMID:30138645 PMID:29911117 PMID:29911117 More... RGD:401850549, RGD:401850577, RGD:401850562, RGD:401850561, RGD:401850561, RGD:401850556, RGD:401850554 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin IMP RGD PMID:22683090 RGD:10003025 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18201294 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Retn resistin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15717844 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 IEP RGD PMID:28598964 RGD:13506959 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Ttc12 tetratricopeptide repeat domain 12 susceptibility ISO DNA:SNP:5'UTR,intron:rs7130431(human) RGD PMID:23303482 RGD:401959304 NCBI chr 8:49,799,916...49,847,940
Ensembl chr 8:49,799,920...49,847,087 		JBrowse link
morphine dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IEP mRNA:increases expression:cerebral cortex (rat) RGD PMID:9105684 RGD:401976538 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 IEP RGD PMID:23927484 RGD:401900655 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ameliorates IMP RGD PMID:21549764 PMID:25746394 RGD:401851922, RGD:11087075 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IDA RGD PMID:24906198 RGD:10054248 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:24906198 RGD:10054248 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment ISO
IEP		 protein:decreased expression:nucleus accumbens RGD PMID:27461790 PMID:32428531 RGD:401940145, RGD:401959372 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cnr1 cannabinoid receptor 1 treatment ISO RGD PMID:27461790 RGD:401940145 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO DNA:SNP:cd: (rs4680) p.V158M (human) RGD PMID:30211780 RGD:401940137 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO
IDA
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:neuron, brain
protein:increased phosphorylation:central amygdaloid nucleus
protein:increased phosphorylation:hypothalamus, ventral tegmental area
mRNA, protein:increased expression:hippocampus, prefrontal cortex		 CTD
RGD		 PMID:11717377 PMID:27053349 PMID:29024786 PMID:19108758 PMID:19052216 More... RGD:401959748, RGD:401959607, RGD:401959375, RGD:401959374, RGD:401950487, RGD:401940184, RGD:401940182, RGD:401940145, RGD:401940122, RGD:401940121, RGD:401940119 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Drd2 dopamine receptor D2 IEP protein:decreased expression:hippocampus (rat) RGD PMID:18276072 RGD:2311587 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Fadd Fas associated via death domain severity IDA RGD PMID:21088039 RGD:11341805 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IDA
IEP
IMP		 RGD PMID:27053349 PMID:12225868 PMID:10998122 RGD:401959748, RGD:405255651, RGD:405100721 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ameliorates IEP protein:increased expression:brain (rat)
associated with pregnancy complications; protein:increased expression:brain (rat)		 RGD PMID:23185589 PMID:33592274 RGD:401851068, RGD:401901281 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gad1 glutamate decarboxylase 1 IEP mRNA:increased expression:dentate gyrus granule cell layer RGD PMID:15673448 RGD:401900167 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment
exacerbates		 ISO
IEP
IMP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:shell of nucleus accumbens, cell surface (rat)
protein:decreased phosphorylation:caudate-putamen, nucleus accumbens (rat)
protein:altered expression:prefrontal cortex, membrane (rat)
rat gene in a mouse model
protein:increased phosphorylation:nucleus accumbens (rat)		 CTD
RGD		 PMID:11404432 PMID:25746394 PMID:34390773 PMID:15287884 PMID:31209728 More... RGD:11087075, RGD:405818276, RGD:405650198, RGD:405649863, RGD:405649739, RGD:405101690, RGD:405100728, RGD:405100238, RGD:405096668, RGD:401976466 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878694 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B treatment ISO RGD PMID:35447543 RGD:405650692 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO protein:increased expression:prefrontal cortex RGD PMID:28082900 RGD:401900741 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO
IDA		 protein:increased phosphorylation:central amygdaloid nucleus RGD PMID:33609567 PMID:29024786 PMID:19052216 PMID:18772347 PMID:27461790 RGD:401940121, RGD:401959607, RGD:401959374, RGD:401950487, RGD:401940145 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO
IDA		 protein:increased phosphorylation:central amygdaloid nucleus RGD PMID:33609567 PMID:29024786 PMID:19052216 PMID:18772347 PMID:27461790 RGD:401940121, RGD:401959607, RGD:401959374, RGD:401950487, RGD:401940145 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 IEP protein:decreased expression, altered form:hippocampus (rat) RGD PMID:15673448 RGD:401900167 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ngf nerve growth factor IEP mRNA,protein:increased expression:central amygdaloid nucleus RGD PMID:22871918 RGD:401965392 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989510 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nps neuropeptide S IDA RGD PMID:23684726 RGD:9831198 NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821 		JBrowse link
G Npsr1 neuropeptide S receptor 1 IEP RGD PMID:23684726 RGD:9831198 NCBI chr 8:22,606,946...22,831,558
Ensembl chr 8:22,606,946...22,831,558 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 treatment IMP RGD PMID:22304485 RGD:401965468 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11027224 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:3720824 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin treatment IEP RGD PMID:15976090 RGD:401850590 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO mRNA, protein:increased expression:hippocampus, prefrontal cortex RGD PMID:19341783 RGD:401940119 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
nicotine dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A susceptibility ISO DNA:SNP:promoter: C-1291G (rs1800544) (human) RGD PMID:17612790 RGD:401976458 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 susceptibility
treatment		 ISO DNA:polymorphism:exon:
associated with depressive disorder;DNA:SNP:exon:rs1800497(human)
DNA:SNPs,haplotype:introns,exons:multiple
DNA:SNP, haplotype:exon:rs1800497(human)
DNA:haplotype: :multiple
DNA:SNP:exon:rs2734849(human)		 RGD PMID:28574012 PMID:21540761 PMID:17085484 PMID:22382052 PMID:25273375 More... RGD:401959222, RGD:401959399, RGD:401959319, RGD:401959315, RGD:401959295, RGD:401959232 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arrb2 arrestin, beta 2 severity ISO DNA,SNPs,haplotype: : RGD PMID:17579607 RGD:401901594 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20418890 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit susceptibility
severity		 ISO CTD Direct Evidence: marker/mechanism
DNA:missense:cds:p.R37H (human)
DNA:SNPs:intron 1,3'UTR: (rs637137,rs578776) (human)
DNA:SNPs:intron,CDS:rs938682,rs1051730 (human)
DNA:SNP:exon: (rs1051730) (human)
associated with smoking; DNA:SNP::rs1051730(human)
DNA:SNP: :rs578776(human)		 CTD
RGD		 PMID:20372150 PMID:20418890 PMID:22042774 PMID:21312287 PMID:27663783 More... RGD:405849405, RGD:401959233, RGD:401901143, RGD:151660346, RGD:150526806, RGD:150524362 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: CHRNA4-related condition | ClinVar Annotator: match by term: Nicotine addiction, protection against		 CTD
OMIM
ClinVar		 PMID:15154117 PMID:19058950 PMID:21683344 PMID:25741868 PMID:26467025 More... NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit susceptibility
severity		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs: :rs16969968, rs2036527(human)
DNA:SNP, missense:CDS:rs16969968 (human)
DNA:SNP:intron:rs17486278(human)
associated with smoking; DNA:SNP::rs16969968 (human)
DNA:SNP: :rs16969968(human)		 CTD
RGD		 PMID:20372150 PMID:29621993 PMID:27663783 PMID:20587604 PMID:29993116 More... RGD:405849275, RGD:401901143, RGD:150527839, RGD:150526806, RGD:150524362 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs2304297(human)
DNA:SNP,haplotypes: :		 CTD
RGD		 PMID:20418888 PMID:18704094 PMID:28851948 RGD:405849394, RGD:405849281 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs: :rs7004381, rs4950,rs13280604(human)
DNA:SNPs,haplotype: :
associated with Parkinson's disease;DNA:polymorphism:promoter:c.-57A>G(human)
DNA:SNP,haplotype:: rs6474413, rs13277254 (human)		 CTD
RGD		 PMID:20418888 PMID:18704094 PMID:28851948 PMID:24731518 PMID:34368810 RGD:405849394, RGD:405849281, RGD:405849280, RGD:405849274 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit susceptibility ISO DNA:missense:cds:p.T91I, p.T375I (human) RGD PMID:22042774 RGD:405849405 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility
sexual_dimorphism
onset
treatment		 ISO DNA:SNP:cd: (rs4680) (human)
DNA:SNPs,haplotypes:promoter,exons:mutliple
DNA:SNPs,haplotype:intron 1: (rs9332377) (human)
DNA:promoter:methylation
DNA:SNP:exon 3: G1947A, p.V158M (rs4680) (human)
DNA:SNPs:3'utr: (rs737865, rs165599) (human)
DNA:SNPs,haplotypes:intron1,exon 4,intron 5: (rs740603,rs4680, rs174699) (human)
DNA:SNP:cd: p.V158M (human)		 RGD PMID:28472995 PMID:16499480 PMID:21312287 PMID:21423427 PMID:17206495 More... RGD:401940107, RGD:401959300, RGD:401959233, RGD:401959312, RGD:401959230, RGD:401940189, RGD:401940152, RGD:401940136 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO mRNA:increased expression:blood, leukocytes RGD PMID:19212318 PMID:20047710 RGD:401940142, RGD:401960087 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 susceptibility
treatment		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :CYP2B6*6 (516G>T,785A>G) ((human)
DNA:polymorphisms: :1459 C/T(human)		 CTD
RGD		 PMID:20418888 PMID:25489907 PMID:17223085 PMID:17654295 RGD:401901146, RGD:401901145, RGD:11096878 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Ddc dopa decarboxylase susceptibility ISO DNA:SNPs,haplotypes::
DNA:SNPs,haplotypes:multiple
DNA:SNPs,haplotypes:introns:multiple (human)		 RGD PMID:17184203 PMID:15879433 PMID:16740595 RGD:401976473, RGD:401976477, RGD:401976474 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Drd2 dopamine receptor D2 treatment
susceptibility		 ISO DNA:polymorphisms: :(human)
DNA:SNPs, insertion/deletion:exon,introns, promoter:multiple
DNA:SNP, haplotype:exon:rs6277 (957C>T)(human)		 RGD PMID:17654295 PMID:17085484 PMID:22382052 RGD:11096878, RGD:401959319, RGD:401959315 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20418890 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Fignl1 fidgetin-like 1 susceptibility ISO DNA:SNP,haplotype:: (rs10230343) (human) RGD PMID:16740595 RGD:401976474 NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP
ISO		 protein:increased expression:caudate-putamen
protein:increased expression:brain		 RGD PMID:15026155 PMID:22048468 PMID:9789813 PMID:26169054 RGD:405100963, RGD:405295496, RGD:405255653, RGD:405101700 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility ISO DNA:SNPs,haplotypes:intron 6,exon 16,intron 17: (rs2267635,rs29230, rs29267) RGD PMID:19763258 RGD:401940104 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 susceptibility ISO ClinVar Annotator: match by term: Tobacco addiction, susceptibility to
DNA:SNPs,haplotypes:multiple
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD
RGD		 PMID:25741868 PMID:28492532 PMID:19763258 RGD:401940104 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO protein:decreased expression:hippocampus, striatum RGD PMID:34508846 RGD:405850211 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B severity ISO DNA:SNP: :rs2268132 RGD PMID:28900078 RGD:401900295 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Hcrt hypocretin neuropeptide precursor ISO mRNA:increased expression:blood (human) RGD PMID:22846875 RGD:401960066 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20514075 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A treatment IEP RGD PMID:22921986 RGD:405850243 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B sexual_dimorphism ISO associated with attention deficit hyperactivity disorder;DNA:SNPs: :rs11568817,rs130058 (human) RGD PMID:28923721 RGD:405650695 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A severity
treatment		 ISO
IMP		 DNA:SNP: :rs6313
DNA:SNPs:promoter, CDS:-1438A>G (rs6311), 102T>C (rs6313)		 RGD PMID:28900078 PMID:22342986 PMID:25366721 RGD:401900295, RGD:401901205, RGD:401900763 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IDA RGD PMID:22342986 RGD:401901205 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO DNA:SNP, haplotype:enhancer: (rs897685) (human)
DNA:SNP, haplotype:intron: (rs10160548) (human)
DNA:SNP:intron: (rs1985242) (human)
DNA:SNPs, haplotype:multiple (human)		 RGD PMID:24590108 PMID:30405098 PMID:35457612 PMID:23290502 RGD:404976878, RGD:405096439, RGD:405096438, RGD:405096435 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 susceptibility ISO DNA:SNP:: (rs1886040) (human) RGD PMID:18438686 RGD:401851917 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 susceptibility ISO DNA:SNPs:introns:multiple RGD PMID:17085484 RGD:401959319 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:hippocampus RGD PMID:34508846 RGD:405850211 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO DNA:SNP, haplotype:exon: (rs10033119) (human) RGD PMID:22309839 RGD:402463945 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprm1 opioid receptor, mu 1 no_association
disease_progression		 ISO DNA:SNP: :rs510769
DNA:SNPs: :multiple		 RGD PMID:26042510 PMID:19959688 RGD:401827930, RGD:401827943 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Rabep2 rabaptin, RAB GTPase binding effector protein 2 IEP protein:increased expression:brain RGD PMID:9789813 RGD:405255653 NCBI chr 1:181,010,305...181,026,651
Ensembl chr 1:181,010,305...181,026,648 		JBrowse link
G Rad52 RAD52 homolog, DNA repair protein susceptibility ISO DNA:SNP:3'utr: (rs7963551) (human) RGD PMID:26629180 RGD:151660337 NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 susceptibility ISO DNA:SNP:: (rs1062935) (human) RGD PMID:18438686 RGD:401851917 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO ClinVar Annotator: match by term: Tobacco addiction, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM
RGD		 PMID:25741868 PMID:28263315 PMID:28492532 PMID:27490263 RGD:401959207 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Ttc12 tetratricopeptide repeat domain 12 susceptibility ISO DNA:haplotype: :rs2282511(human)
DNA:SNPs,haplotype:introns,intergenics:multiple		 RGD PMID:25273375 PMID:17085484 RGD:401959295, RGD:401959319 NCBI chr 8:49,799,916...49,847,940
Ensembl chr 8:49,799,920...49,847,087 		JBrowse link
opiate dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A severity
susceptibility
treatment		 ISO DNA:SNP: :3435C>T (rs1045642) (human)
DNA:SNP:: (rs9282564)
DNA:SNPs::rs1045642, rs2032582(human)
DNA:haplotype::		 RGD PMID:27061230 PMID:24950410 PMID:24086514 PMID:17178268 RGD:401959589, RGD:401827941, RGD:401901242, RGD:401901190 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 susceptibility ISO DNA:SNP,haplotype:exon:rs1800497(human) RGD PMID:19373123 RGD:401959309 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arrb2 arrestin, beta 2 treatment ISO DNA:SNPs: :rs3786047, rs1045280, rs2036657(human)
protein:decreased expression:pre-frontal cortex		 RGD PMID:20514076 PMID:14969742 RGD:401901595, RGD:401901596 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO protein:increased expression:serum RGD PMID:21890593 RGD:405850248 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bmper BMP-binding endothelial regulator susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs731844) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256 		JBrowse link
G C9 complement C9 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs476569) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Ces1d carboxylesterase 1D ISO CTD Direct Evidence: therapeutic CTD PMID:12679808 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Comt catechol-O-methyltransferase severity
treatment		 ISO DNA:SNP:cd: p.V158M (rs4680) (human) RGD PMID:27061230 PMID:32407152 RGD:401959589, RGD:401959744 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 treatment ISO RGD PMID:10653207 RGD:401901270 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Drd2 dopamine receptor D2 treatment
susceptibility		 ISO DNA:SNP: :rs6275(human)
DNA:SNP,haplotype: :rs1076560,rs6275(human)		 RGD PMID:19373123 PMID:19373123 RGD:401959309, RGD:401959309 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gal galanin and GMAP prepropeptide susceptibility ISO DNA:SNP: :rs948854(human) RGD PMID:24086514 RGD:401901242 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO protein:decreased expression:pre-frontal cortex RGD PMID:14969742 RGD:401901596 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO protein:decreased expression:pre-frontal cortex RGD PMID:14969742 RGD:401901596 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Nav3 neuron navigator 3 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs770124) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698 		JBrowse link
G Ngf nerve growth factor ISO DNA:hypermethylation:promoter,exon:blood
protein:decreased expression:brain		 RGD PMID:29224006 PMID:26440527 RGD:401976280, RGD:401976545 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 susceptibility ISO DNA:SNP, haplotype:enhancer: (rs4128839) (human)
DNA:SNP, haplotype:intron: (rs4691910) (human)		 RGD PMID:31689297 PMID:32757697 RGD:402463939, RGD:402463942 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprd1 opioid receptor, delta 1 susceptibility
treatment		 ISO DNA:SNP: :rs1042114 (human)
DNA:SNPs, haplotype:intron 1:multiple (human)
associated with neonatal abstinence syndrome in offspring;DNA:SNP:intron (rs204076) (human)
associated with African American;DNA:SNP:intron (rs678849) (human)
associated with methadone treatment;DNA:SNP:intron (rs204076) (human)
DNA:SNP:intron (rs10753331, rs581111) (human)
DNA:SNP,haplotype:multiple (multiple)(human)
DNA:SNP, haplotype: (rs678849|rs2236857|rs2236855|rs760589) (human)
DNA:SNP: :rs2236861(human)		 RGD PMID:28656735 PMID:24533225 PMID:26233486 PMID:23612435 PMID:37531661 More... RGD:401850580, RGD:402525443, RGD:11079504, RGD:402463973, RGD:401977581, RGD:401976559, RGD:401976552, RGD:401976541, RGD:401901242 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 no_association ISO DNA:SNP: :rs702764 (human)
DNA:SNP,haplotype:multiple (multiple GGCTTCT) (human)		 RGD PMID:28656735 PMID:17622222 RGD:401850580, RGD:401976552 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 susceptibility
treatment
no_association		 ISO ClinVar Annotator: match by term: Opioid dependence, susceptibility to, 1
protein:decreased expression:pre-frontal cortex
DNA:SNP: :rs9479757(human)
DNA:SNP, haplotype:3' utr:rs10485058 (human)
associated with Chronic Pain;DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:altered methylation:promoter
DNA:SNPs: :multiple
associated with alcohol dependence:DNA:SNP, haplotypes: :-2044C>A (human)
DNA:SNPs: :172G>T (rs6912029), 1510G>A (rs12205732) (human)
DNA:hypermethylation:promoter
DNA:SNP:exon:17C>T (rs 1799972) (human)
DNA:SNP:exon:118A>G (rs 1799971) (human)		 ClinVar
RGD		 PMID:9193881 PMID:9689128 PMID:11134674 PMID:11773858 PMID:11773859 More... RGD:401901596, RGD:401901242, RGD:401831043, RGD:401831042, RGD:401831040, RGD:401827954, RGD:401827948, RGD:401827945, RGD:401827942, RGD:401827937, RGD:401827935, RGD:401827933, RGD:401827929, RGD:401827929 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin sexual_dimorphism
no_association
susceptibility		 ISO DNA:SNP: :rs1022563 (human)
DNA:SNPs:promoter, 3' utr:rs1997794, rs102256
DNA:SNP: :rs199774, rs1022563 (human)
DNA:SNP: :rs910080 (human)
DNA:SNP: :rs910080, rs199774 (human)		 RGD PMID:22443215 PMID:19298317 PMID:28656735 PMID:28656735 PMID:22443215 RGD:401850569, RGD:401850586, RGD:401850580, RGD:401850580, RGD:401850569 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10321497 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Ttc9 tetratricopeptide repeat domain 9 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs8688) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 6:101,333,274...101,368,110
Ensembl chr 6:101,333,141...101,368,110 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO DNA:hypermethylation:exon:blood RGD PMID:29224006 RGD:401976280 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    Chemically-Induced Disorders 1394
      substance-related disorder 713
        substance dependence 149
          alcohol dependence 78
          drug dependence + 97
          nicotine dependence 40
Path 2
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      nervous system disease 14116
        central nervous system disease 12429
          brain disease 11666
            disease of mental health 8318
              substance-related disorder 713
                substance dependence 149
                  alcohol dependence 78
                  drug dependence + 97
                  nicotine dependence 40
paths to the root