RGD Reference Report - CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence. - Rat Genome Database

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CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence.

Authors: Riccardi, Laura Natalia  Carano, Francesco  Bini, Carla  Ceccardi, Stefania  Ferri, Gianmarco  Pelotti, Susi 
Citation: Riccardi LN, etal., Genet Test Mol Biomarkers. 2015 Feb;19(2):103-7. doi: 10.1089/gtmb.2014.0239. Epub 2014 Dec 9.
RGD ID: 401901146
Pubmed: PMID:25489907   (View Abstract at PubMed)
DOI: DOI:10.1089/gtmb.2014.0239   (Journal Full-text)

The extensively polymorphic CYP2B6 gene metabolizes endogenous and exogenous compounds, among which are nicotine and bupropion, although its contribution to the systemic metabolism of nicotine still remains controversial. In the present study, the distribution of the CYP2B6 variant and genotype frequencies were analyzed in a sample of 202 Italian individuals who were also invited to answer the Fagerström test for nicotine dependence (FTND), in an effort to assess the involvement of CYP2B6 polymorphisms in nicotine dependence. Eight single-nucleotide polymorphisms of CYP2B6 were tested and seven different variants were identified showing frequencies similar to the European population. The reduced activity of the CYP2B6*6 variant was significantly (p=0.025) distributed among the nicotine-dependent individuals compared to non-nicotine dependents. Also, the CYP2B6*1/*6 genotype achieved statistical significance (p=0.016) within the nicotine-dependent individuals. The high occurrence of CYP2B6*6 carriers among nicotine-dependent individuals may suggest a possible involvement in nicotine dependence, with a potential impact on smoking cessation treatments tailored to the individual smoker's genotype.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nicotine dependence susceptibilityIAGP 401901146DNA:SNP: :CYP2B6*6 (516G>T and 785A>G) ((human)RGD 
nicotine dependence susceptibilityISOCYP2B6 (Homo sapiens)401901146; 401901146DNA:SNP: :CYP2B6*6 (516G>T and 785A>G) ((human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp2b3  (cytochrome P450, family 2, subfamily b, polypeptide 3)

Genes (Mus musculus)
Cyp2b10  (cytochrome P450, family 2, subfamily b, polypeptide 10)

Genes (Homo sapiens)
CYP2B6  (cytochrome P450 family 2 subfamily B member 6)


Additional Information