RGD Reference Report - Possible role of nerve growth factor in the pathogenesis of alcohol dependence. - Rat Genome Database

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Possible role of nerve growth factor in the pathogenesis of alcohol dependence.

Authors: Yoon, Su-Jung  Roh, Sungwon  Lee, Heejin  Lee, Ji-Youl  Lee, Bun-Hee  Kim, Yong-Ku  Kim, Dai-Jin 
Citation: Yoon SJ, etal., Alcohol Clin Exp Res. 2006 Jun;30(6):1060-5. doi: 10.1111/j.1530-0277.2006.00120.x.
RGD ID: 401965409
Pubmed: PMID:16737466   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1530-0277.2006.00120.x   (Journal Full-text)


BACKGROUND: Recent studies have raised the possibility that nerve growth factor (NGF) is abnormally regulated in the central nervous system (CNS) of animal models of chronic ethanol treatment. The goals of this study were to determine whether prolonged alcohol consumption is associated with the plasma NGF levels and to assess the effect of a positive family history of alcohol dependence on plasma NGF levels in the alcohol-dependent patients.
METHODS: We used the enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of peripheral NGF in patients with alcohol dependence and in a control group.
RESULTS: The plasma NGF concentrations in the alcohol-dependent patients were significantly lower than in the controls (71.9 vs 110.5 pg/mL, respectively). Moreover, the alcohol-dependent patients with positive family histories showed a greater decrease in their NGF levels than those subjects with negative family histories (64.7 vs 83.3 pg/mL, respectively).
CONCLUSIONS: Our study suggests that the NGF levels may be a trait marker for the development of alcohol dependence.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
alcohol dependence  IEP 401965409protein:decreased expression:plasmaRGD 
alcohol dependence  ISONGF (Homo sapiens)401965409; 401965409protein:decreased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngf  (nerve growth factor)

Genes (Mus musculus)
Ngf  (nerve growth factor)

Genes (Homo sapiens)
NGF  (nerve growth factor)


Additional Information