RGD Reference Report - Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor expression in rats. - Rat Genome Database

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Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor expression in rats.

Authors: Jiang, Wei-Ning  Jing, Xiao  Li, Man  Deng, Hong  Jiang, Tao  Xiong, Ke-Zhao  Chen, Ying  Wang, Xiao-Fei  Wang, Quan-Jun 
Citation: Jiang WN, etal., Eur J Pharmacol. 2020 Oct 5;884:173397. doi: 10.1016/j.ejphar.2020.173397. Epub 2020 Jul 25.
RGD ID: 405100728
Pubmed: PMID:32717192   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2020.173397   (Journal Full-text)

Corydalis is a Chinese herb that has been used in China for hundreds of years for analgesic and other purposes. Corydaline and l-tetrahydropalmatine (l-THP) are the main active ingredients of Corydalis. This study was aimed to study the potential utility of corydaline and l-THP in the treatment of opioid abuse and addiction and explore the possible mechanisms underlying their pharmacological actions. Conditioned place preference (CPP) was used to evaluate the rewarding effects of morphine and Western-blot immunoreactive assays were used to evaluate morphine-induced changes in dopamine D2 receptor and GluA1 AMPA receptor and GluA2 AMPA receptor expression in the brain of rats. Systemic administration of corydaline (5 mg/kg, i.p.) or l-THP (1.25, 2.5,5 mg/kg) significantly inhibited the acquisition and expression of morphine-induced CPP in a dose-dependent manner. Corydaline or l-THP alone, at the same doses, failed to produce CPP or conditioned place aversion, and didn't affect locomotor activity. We then examined the expression of dopamine D2 receptor and GluA1 AMPA receptor and GluA2 AMPA receptor subunit expression in rats after acquisition of morphine-induced CPP. We found that repeated administration of morphine produced a significant reduction in dopamine D2 receptor expression in the prefrontal cortex, hippocamps, and striatum, while an increase in the striatal GluA1 AMPA receptor expression. Pretreatment with corydaline or l-THP blocked morphine-induced dopamine D2 receptor down-regulation and GluA1 AMPA receptor up-regulation in these brain regions. Corydaline and l-THP may have therapeutic potential in prevention and treatment of opioid abuse and addiction. The underlying mechanisms may be related to their antagonism on morphine-induced changes in dopamine and glutamate transmission in the brain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
morphine dependence treatmentISOGria1 (Rattus norvegicus)405100728; 405100728 RGD 
morphine dependence treatmentIEP 405100728 RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
corydaline multiple interactionsISOGria1 (Rattus norvegicus)405100728; 405100728Corydaline inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum]RGD 
corydaline multiple interactionsEXP 405100728Corydaline inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum]RGD 
morphine increases expression ISOGria1 (Rattus norvegicus)405100728; 405100728Morphine increases expression of Gria1 protein in the striatumRGD 
morphine increases expression EXP 405100728Morphine increases expression of Gria1 protein in the striatumRGD 
tetrahydropalmatine multiple interactionsISOGria1 (Rattus norvegicus)405100728; 405100728L-THP inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum]RGD 
tetrahydropalmatine multiple interactionsEXP 405100728L-THP inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum]RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to morphine  IEP 405100728 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)

Genes (Mus musculus)
Gria1  (glutamate receptor, ionotropic, AMPA1 (alpha 1))

Genes (Homo sapiens)
GRIA1  (glutamate ionotropic receptor AMPA type subunit 1)


Additional Information