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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gria1
Name: glutamate ionotropic receptor AMPA type subunit 1
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gria1affects expression EXP 405649863RGDMorphine alters expression of Gria1 protein in prefrontal cortex membrane 
Gria1decreases phosphorylationEXP 405650198RGDMorphine decreases phosphorylation of Gria1 protein in the caudate-putamen, nucleus accumbens 
Gria1increases expression EXP 405100238RGDMorphine increases expression of Gria1 protein in the central amygdaloid nucleus 
Gria1increases expression EXP 405100728RGDMorphine increases expression of Gria1 protein in the striatum 
Gria1increases phosphorylationEXP 405101691RGDMorphine withdrawal increases phosphorylation of Gria1 protein in hippocampal formation postsynaptic density 
Gria1decreases expressionEXP 6480464CTDMorphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 proteinPMID:15183518 PMID:23711322
Gria1decreases phosphorylationEXP 6480464CTDMorphine results in decreased phosphorylation of GRIA1 proteinPMID:15287884
Gria1increases expressionEXP 6480464CTDMorphine results in increased expression of GRIA1 mRNAPMID:15183518
Gria1multiple interactionsEXP 6480464CTDMorphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]PMID:25643298
Gria1affects response to substanceISOGria1 (Mus musculus)6480464CTDGRIA1 protein affects the susceptibility to MorphinePMID:11404432
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