RGD Reference Report - Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population.

Authors: Han, Sichong  Gao, Feng  Yang, Wenjun  Ren, Yanli  Liang, Xue  Xiong, Xiangyu  Pan, Wenting  Zhou, Liqing  Zhou, Changchun  Ma, Fei  Yang, Ming 
Citation: Han S, etal., Int J Clin Exp Med. 2015 Sep 15;8(9):16528-35. eCollection 2015.
RGD ID: 151660337
Pubmed: PMID:26629180   (View Abstract at PubMed)
PMCID: PMC4659068   (View Article at PubMed Central)

As a well-known DNA repair gene, RAD52 plays an essential role in homologous recombination repair of double strand break, maintenance of genomic stability and prevention of cell malignant transformation. Previous genome-wide association studies (GWASs) have identified common genetic variants at 12p13.33 RAD52 locus associated with lung cancer risk in Caucasians. However, little or nothing has been known about the RAD52 single nucleotide polymorphisms (SNPs) in small cell lung cancer (SCLC) in the Chinese population. As a result, we examined the association between six RAD52 SNPs (rs10849605, rs1051669, rs10774474, rs11571378, rs7963551 and rs6489769) and SCLC susceptibility in Chinese. After 520 SCLC cases and 1040 controls in two independent case-control sets were genotyped, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. We found that only the RAD52 rs7963551 SNP was significantly associated with SCLC risk among six RAD52 SNPs genotyped. The odds of having the rs7963551 CA genotype in SCLC patients was 0.38 (95% CI = 0.24-0.62, P = 1.1×10(-4)) compared with the CC genotype. Stratified analyses of association between rs7963551 SNP and SCLC risk indicated that the functional polymorphism was only significantly associated with decreased risk among smokers but not nonsmokers. Our results demonstrated that the functional RAD52 rs7963551 SNP contributes to susceptibility to developing SCLC in the Chinese population.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RAD52Humanlung small cell carcinoma susceptibilityIAGP DNA:SNP:3'utr: (rs7963551) (human)RGD 
Rad52Ratlung small cell carcinoma susceptibilityISORAD52 (Homo sapiens)DNA:SNP:3'utr: (rs7963551) (human)RGD 
Rad52Mouselung small cell carcinoma susceptibilityISORAD52 (Homo sapiens)DNA:SNP:3'utr: (rs7963551) (human)RGD 
RAD52Humannicotine dependence susceptibilityIAGP DNA:SNP:3'utr: (rs7963551) (human)RGD 
Rad52Ratnicotine dependence susceptibilityISORAD52 (Homo sapiens)DNA:SNP:3'utr: (rs7963551) (human)RGD 
Rad52Mousenicotine dependence susceptibilityISORAD52 (Homo sapiens)DNA:SNP:3'utr: (rs7963551) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RAD52HumanAddictive nicotine use susceptibilityIAGP DNA:SNP:3'utr: (rs7963551) (human)RGD 
RAD52HumanSmall cell lung carcinoma susceptibilityIAGP DNA:SNP:3'utr: (rs7963551) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Rad52  (RAD52 homolog, DNA repair protein)

Genes (Mus musculus)
Rad52  (RAD52 homolog, DNA repair protein)

Genes (Homo sapiens)
RAD52  (RAD52 homolog, DNA repair protein)


Additional Information