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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:puerarin
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Accession:CHEBI:8633 term browser browse the term
Definition:A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol
 related_synonym: (1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-D-glucitol;   8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;   Formula=C21H20O9;   InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1;   InChIKey=HKEAFJYKMMKDOR-VPRICQMDSA-N;   NPI 031G;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)ccc2c1occ(-c1ccc(O)cc1)c2=O;   daidzein 8-C-glucoside;   kakonein
 xref: CAS:3681-99-0;   DrugBank:DB12290;   FooDB:FDB029976;   HMDB:HMDB0240265;   KEGG:C10524;   KNApSAcK:C00006094;   LIPID_MAPS_instance:LMPK12050005
 xref_mesh: MESH:C033607
 xref: MetaCyc:CPD-25752;   PMID:25310912;   PMID:25553536;   PMID:35807322;   PMID:36537316;   PMID:36815035;   PMID:37404717;   PMID:37705868;   PMID:37789701;   PMID:37801894;   PMID:38001459;   PMID:38043717;   PMID:38101001;   PMID:38114205;   PMID:38162309;   PMID:38196088;   PMID:38213236;   PMID:38215026;   PMID:38215692;   PMID:38255784;   PMID:38282474;   PMID:38283163;   PMID:38287862;   PMID:38305024;   PMID:38308547;   PMID:38323179;   Reaxys:64198;   Wikipedia:Puerarin
 cyclic_relationship: is_conjugate_acid_of CHEBI:229573


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puerarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP puerarin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin] CTD PMID:34217736 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA] CTD PMID:31273855 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACACB acetyl-CoA carboxylase beta multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACB mRNA] CTD PMID:31273855 NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226 		JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain increases expression ISO puerarin results in increased expression of ACADM mRNA CTD PMID:31273855 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO puerarin inhibits the reaction [lead acetate results in decreased expression of ACHE protein] CTD PMID:23501611 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACLY ATP citrate lyase increases expression EXP puerarin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression ISO puerarin results in increased expression of ACOX1 mRNA CTD PMID:31273855 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACTA2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:27318789 PMID:31273855 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP puerarin results in increased phosphorylation of AKT1 protein
fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of AKT1 protein]		 CTD PMID:21884717 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALB albumin multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein] CTD PMID:23146695 PMID:23500774 PMID:27318789 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G AQP1 aquaporin 1 (Colton blood group) increases expression EXP puerarin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517 		JBrowse link
G AQP3 aquaporin 3 (Gill blood group) increases expression EXP puerarin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 9:33,441,160...33,447,593
Ensembl chr 9:33,441,156...33,447,596 		JBrowse link
G AR androgen receptor decreases expression EXP puerarin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 puerarin results in increased expression of BAX protein
puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX protein]		 CTD PMID:16055262 PMID:27717697 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 puerarin results in decreased expression of BCL2 mRNA; puerarin results in decreased expression of BCL2 protein
puerarin inhibits the reaction [[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]
Arsenic Trioxide promotes the reaction [puerarin results in decreased expression of BCL2 mRNA]; puerarin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]		 CTD PMID:16055262 PMID:16426832 PMID:20416161 PMID:27717697 PMID:35331853 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions
decreases expression		 EXP arsenic trioxide promotes the reaction [puerarin results in decreased expression of BIRC5 mRNA] CTD PMID:20416161 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CASP1 caspase 1 multiple interactions EXP puerarin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein] CTD PMID:35331853 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity		 EXP
ISO		 arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP3 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]
puerarin results in increased activity of CASP3 protein
puerarin inhibits the reaction [cadmium acetate results in increased activity of CASP3 protein]; puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]; puerarin results in decreased expression of and results in decreased activity of CASP3 protein		 CTD PMID:16041641 PMID:16055262 PMID:20416161 PMID:24505050 PMID:27318789 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases expression
multiple interactions		 EXP puerarin results in increased expression of CASP8 protein
arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein]		 CTD PMID:20416161 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CAT catalase multiple interactions ISO puerarin inhibits the reaction [cadmium acetate results in increased activity of CAT protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein] CTD PMID:23315276 PMID:24975872 PMID:34897960 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCN2 cellular communication network factor 2 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of CCN2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA] CTD PMID:27318789 PMID:31273855 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CDH1 cadherin 1 increases expression EXP puerarin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of COL1A1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:27318789 PMID:31273855 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] CTD PMID:23500774 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression ISO puerarin results in increased expression of CPT1A mRNA CTD PMID:31273855 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein] CTD PMID:26607348 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CTSK cathepsin K multiple interactions ISO puerarin inhibits the reaction [cadmium acetate results in decreased expression of CTSK protein]; puerarin inhibits the reaction [cadmium acetate results in increased expression of CTSK mRNA] CTD PMID:34897960 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CYGB cytoglobin decreases expression EXP puerarin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr17:76,527,356...76,551,193
Ensembl chr17:76,527,356...76,551,175 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases expression		 ISO puerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]
puerarin results in increased expression of CYP2E1 protein		 CTD PMID:18038910 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO puerarin affects the reaction [Lead affects the expression of CYP7A1] CTD PMID:22001170 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G DSG3 desmoglein 3 decreases expression EXP puerarin results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:31,447,741...31,478,702
Ensembl chr18:31,447,741...31,478,702 		JBrowse link
G EGF epidermal growth factor decreases expression EXP puerarin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 ISO puerarin results in decreased phosphorylation of EIF4EBP1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:27762461 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G ESR1 estrogen receptor 1 decreases expression ISO puerarin results in decreased expression of ESR1 mRNA CTD PMID:22919047 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 decreases activity
decreases expression		 EXP
ISO		 puerarin results in decreased activity of ESR2 protein
puerarin results in decreased expression of ESR2 mRNA		 CTD PMID:18937077 PMID:20706672 PMID:22919047 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FASLG Fas ligand multiple interactions
increases expression		 EXP arsenic trioxide promotes the reaction [puerarin results in increased expression of FASLG protein] CTD PMID:20416161 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FASN fatty acid synthase multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of FASN mRNA] CTD PMID:31273855 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FBN1 fibrillin 1 decreases expression EXP puerarin results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,313...48,645,721 		JBrowse link
G FBN2 fibrillin 2 decreases expression EXP puerarin results in decreased expression of FBN2 mRNA CTD PMID:20706672 NCBI chr 5:128,257,909...128,538,245
Ensembl chr 5:128,257,909...128,659,185 		JBrowse link
G FGF1 fibroblast growth factor 1 increases expression EXP puerarin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP puerarin results in increased expression of FOS mRNA CTD PMID:17142977 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein; FYN protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; Lithium Chloride inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein]		 CTD PMID:32763437 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions ISO [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA; [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA; [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein]		 CTD PMID:32763437 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GDNF glial cell derived neurotrophic factor multiple interactions EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]; puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein] CTD PMID:27796870 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression		 EXP Sirolimus inhibits the reaction [puerarin results in increased expression of GPER1 protein] CTD PMID:27796870 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815 		JBrowse link
G GPI glucose-6-phosphate isomerase multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of GPI mRNA] CTD PMID:33404196 NCBI chr19:34,359,718...34,402,413
Ensembl chr19:34,359,480...34,402,413 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased activity of GPT protein] CTD PMID:26607348 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased phosphorylation of GSK3B protein CTD PMID:32763437 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSR glutathione-disulfide reductase increases expression
multiple interactions		 ISO puerarin results in increased expression of GSR protein
puerarin inhibits the reaction [Lead results in decreased activity of GSR protein]		 CTD PMID:18038910 PMID:22001170 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HAS1 hyaluronan synthase 1 decreases expression EXP puerarin results in decreased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr19:51,713,112...51,723,991
Ensembl chr19:51,713,112...51,723,991 		JBrowse link
G HK1 hexokinase 1 multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of HK1 mRNA] CTD PMID:33404196 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO puerarin affects the reaction [Lead affects the expression of HMGCR] CTD PMID:22001170 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO bisindolylmaleimide I inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]
puerarin results in increased expression of HMOX1 mRNA; puerarin results in increased expression of HMOX1 protein		 CTD PMID:20060010 PMID:24975872 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 increases expression EXP puerarin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21884717 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IFNG mRNA] CTD PMID:31273855 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IGF1 insulin like growth factor 1 decreases expression
multiple interactions		 EXP
ISO		 puerarin results in decreased expression of IGF1 mRNA
puerarin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]		 CTD PMID:20706672 PMID:23927877 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL18 interleukin 18 multiple interactions EXP PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]] CTD PMID:35331853 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1A interleukin 1 alpha decreases expression EXP puerarin results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP		 puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL1B mRNA]
PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]		 CTD PMID:31273855 PMID:35331853 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL6 mRNA]; puerarin inhibits the reaction [nickel sulfate results in increased expression of IL6 protein] CTD PMID:26607348 PMID:31273855 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INSR insulin receptor multiple interactions ISO puerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] CTD PMID:23927877 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G KL klotho decreases expression EXP puerarin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 multiple interactions ISO puerarin promotes the reaction [cadmium acetate results in decreased expression of LAMTOR1 protein] CTD PMID:34897960 NCBI chr11:72,097,292...72,103,297
Ensembl chr11:72,085,895...72,103,297 		JBrowse link
G LDHA lactate dehydrogenase A multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of LDHA protein] CTD PMID:33404196 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425 		JBrowse link
G LDLR low density lipoprotein receptor multiple interactions ISO puerarin affects the reaction [Lead affects the expression of LDLR] CTD PMID:22001170 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LIF LIF interleukin 6 family cytokine decreases expression ISO puerarin results in decreased expression of LIF mRNA CTD PMID:22919047 NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO puerarin inhibits the reaction [cadmium acetate results in decreased expression of MAP1LC3B protein modified form] CTD PMID:34897960 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 puerarin results in increased phosphorylation of MAPK1 protein
puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]		 CTD PMID:21884717 PMID:24975872 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP
ISO		 puerarin results in increased phosphorylation of MAPK3 protein
puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21884717 PMID:24975872 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression		 EXP arsenic trioxide promotes the reaction [puerarin results in increased expression of MAPK8 protein]
puerarin results in increased phosphorylation of MAPK8 protein		 CTD PMID:20416161 PMID:21884717 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP puerarin results in increased phosphorylation of MAPK9 protein CTD PMID:21884717 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MC1R melanocortin 1 receptor decreases expression EXP puerarin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA] CTD PMID:23500774 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I increases expression
multiple interactions		 EXP
ISO		 puerarin results in increased expression of COX1 mRNA
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]		 CTD PMID:20706672 PMID:23315276 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA] CTD PMID:23315276 NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269 		JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III multiple interactions ISO puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA] CTD PMID:23315276 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation		 EXP
ISO		 Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein]
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]		 CTD PMID:27762461 PMID:27796870 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP puerarin results in decreased expression of MYC protein CTD PMID:16055262 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization		 ISO [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of and affects the localization of NFE2L2 protein; FYN protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; Lithium Chloride inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]
[1-Methyl-4-phenylpyridinium co-treated with puerarin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein]
puerarin affects the localization of NFE2L2 protein		 CTD PMID:24975872 PMID:32763437 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO puerarin inhibits the reaction [Ethanol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]; puerarin inhibits the reaction [Ethanol results in decreased activity of [NFKB1 protein binds to NFKB1 protein]]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:17887948 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein] CTD PMID:27318789 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:35331853 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions ISO puerarin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein] CTD PMID:23501611 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression
multiple interactions		 EXP
ISO		 puerarin results in decreased expression of NOS2 mRNA
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]		 CTD PMID:20706672 PMID:23146695 PMID:24975872 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
increases expression
increases activity		 EXP
ISO		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; [puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; Fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; Fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; W 7 inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; W 7 inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]
puerarin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]
puerarin results in increased expression of NOS3 mRNA
puerarin results in increased activity of NOS3 protein		 CTD PMID:20706672 PMID:21884717 PMID:23501611 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]
puerarin results in increased expression of NQO1 protein		 CTD PMID:24975872 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO puerarin inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein]
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PARP1 protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PARP1 protein]		 CTD PMID:27318789 PMID:27717697 PMID:31273855 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PFKP phosphofructokinase, platelet multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PFKP mRNA] CTD PMID:33404196 NCBI chr10:3,067,548...3,136,805
Ensembl chr10:3,066,333...3,137,718 		JBrowse link
G PGAM1 phosphoglycerate mutase 1 multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PGAM1 mRNA] CTD PMID:33404196 NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444 		JBrowse link
G PGR progesterone receptor decreases expression
increases expression		 EXP
ISO		 puerarin results in decreased expression of PGR mRNA
puerarin results in increased expression of PGR protein		 CTD PMID:17142977 PMID:20706672 PMID:22919047 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 increases expression EXP puerarin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr 7:101,205,984...101,217,581
Ensembl chr 7:101,205,977...101,218,420 		JBrowse link
G PML PML nuclear body scaffold multiple interactions
decreases expression		 EXP arsenic trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form] CTD PMID:20416161 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA mRNA]; puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA protein]; puerarin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] CTD PMID:23927877 PMID:31273855 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases expression		 ISO
EXP		 puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]
puerarin results in decreased expression of PPARG mRNA		 CTD PMID:20706672 PMID:23500774 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A protein] CTD PMID:33404196 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein] CTD PMID:35331853 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PRKCD protein kinase C delta multiple interactions
increases phosphorylation		 ISO PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
puerarin results in increased phosphorylation of PRKCD protein		 CTD PMID:20060010 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PTGER1 prostaglandin E receptor 1 decreases expression EXP puerarin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:14,472,466...14,475,354
Ensembl chr19:14,472,466...14,475,354 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO puerarin results in decreased expression of PTGS2 mRNA
puerarin inhibits the reaction [nickel sulfate results in increased expression of PTGS2 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]		 CTD PMID:22919047 PMID:24975872 PMID:26607348 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions EXP puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of PYCARD protein] CTD PMID:35331853 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G RARA retinoic acid receptor alpha multiple interactions
increases expression
decreases expression		 EXP arsenic trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form]
puerarin results in increased expression of RARA mRNA		 CTD PMID:20416161 PMID:20706672 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; puerarin inhibits the reaction [nickel sulfate affects the localization of RELA protein]
puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]]		 CTD PMID:17887948 PMID:21884717 PMID:24975872 PMID:26607348 PMID:27318789 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 increases phosphorylation
multiple interactions		 EXP
ISO		 puerarin results in increased phosphorylation of RPS6KB1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]
Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of RPS6KB1 protein]		 CTD PMID:27762461 PMID:27796870 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions ISO puerarin inhibits the reaction [cadmium acetate results in decreased expression of RUNX2 protein] CTD PMID:34897960 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO
EXP		 puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein]
puerarin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]		 CTD PMID:33404196 PMID:35331853 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC25A4 solute carrier family 25 member 4 multiple interactions ISO puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 protein] CTD PMID:27717697 NCBI chr 4:185,143,266...185,150,382
Ensembl chr 4:185,143,266...185,150,382 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 multiple interactions ISO puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 protein] CTD PMID:27717697 NCBI chr  X:119,468,444...119,471,396
Ensembl chr  X:119,468,422...119,471,396 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SLC2A1 protein] CTD PMID:33404196 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO puerarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of SOD2 protein] CTD PMID:36527706 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOD3 superoxide dismutase 3 decreases expression EXP puerarin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions ISO puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein]; puerarin promotes the reaction [cadmium acetate results in increased expression of SQSTM1 protein] CTD PMID:27762461 PMID:34897960 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 decreases expression EXP puerarin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 2:31,522,480...31,663,009
Ensembl chr 2:31,522,480...31,580,938 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA] CTD PMID:31273855 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TERT telomerase reverse transcriptase decreases expression EXP puerarin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of TGFB1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]		 CTD PMID:23146695 PMID:27318789 PMID:31273855 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:23500774 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased expression of TLR4 protein] CTD PMID:26607348 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases activity		 EXP
ISO		 puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein]
puerarin inhibits the reaction [nickel sulfate results in increased expression of TNF protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
puerarin results in decreased activity of TNF protein		 CTD PMID:21884717 PMID:23146695 PMID:26607348 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b multiple interactions ISO puerarin promotes the reaction [cadmium acetate results in increased expression of TNFRSF11B mRNA] CTD PMID:34897960 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO [cadmium acetate co-treated with puerarin] results in increased expression of TNFSF11 mRNA CTD PMID:34897960 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TPT1 tumor protein, translationally-controlled 1 increases expression EXP puerarin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,284 		JBrowse link
G TXN thioredoxin increases expression EXP puerarin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
G TYRP1 tyrosinase related protein 1 decreases expression EXP puerarin results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 9:12,693,385...12,710,285
Ensembl chr 9:12,685,439...12,710,285 		JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in increased expression of UCP2 protein] CTD PMID:33404196 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases metabolic processing EXP UGT1A1 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases metabolic processing EXP UGT1A10 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases metabolic processing EXP UGT1A3 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing EXP UGT1A6 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases metabolic processing EXP UGT1A7 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases metabolic processing EXP UGT1A8 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases metabolic processing EXP UGT1A9 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO puerarin results in decreased expression of VEGFA mRNA CTD PMID:22919047 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G XIAP X-linked inhibitor of apoptosis increases expression ISO puerarin results in increased expression of XIAP protein CTD PMID:16041641 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      chemical role 24245
        antioxidant 17490
          puerarin 134
            3''-oxopuearin 0
            puerarin xyloside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  oxacycle 20023
                                    benzopyran 12740
                                      1-benzopyran 12476
                                        isoflavonoid 3883
                                          isoflavones 3865
                                            isoflavone 293
                                              puerarin 134
                                                3''-oxopuearin 0
                                                puerarin xyloside 0
paths to the root