Gene: PRKAA1 (protein kinase, AMP-activated, alpha 1 catalytic subunit)  Homo sapiens
Symbol: PRKAA1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Description: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK alpha 1; AMPK subunit alpha-1; AMPKa1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; MGC33776; MGC57364; OTTHUMP00000161795; OTTHUMP00000161796; tau-protein kinase PRKAA1
Orthologs: Mus musculus : Prkaa1 (protein kinase, AMP-activated, alpha 1 catalytic subunit)  MGI
Rattus norvegicus : Prkaa1 (protein kinase, AMP-activated, alpha 1 catalytic subunit)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_1540,704,256 - 40,743,073-NCBI
Human Genome Assembly HuRef540,711,304 - 40,750,184-NCBI
Human Genome Assembly GRCh37540,759,481 - 40,798,297-NCBI
Human Genome Assembly Build 36540,795,238 - 40,834,054-NCBI
Human Cytogenetic Map5p12 NCBI
Human Genome Assembly540,795,238 - 40,834,046 NCBI
Model

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Sequence

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Nomenclature History
  
More on PRKAA1
Entrez Gene
Ensembl Gene
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HGNC Report
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Vista
Vista + UCSC

RGD Object Information
RGD ID: 732865
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2013-05-28
Status: ACTIVE



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