CTSK (cathepsin K) - Rat Genome Database

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene: CTSK (cathepsin K) Homo sapiens

Symbol:

CTSK

Name:

cathepsin K

Description:

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cathepsin K; cathepsin O; cathepsin O1; cathepsin O2; cathepsin X; CTS02; CTSO; CTSO1; CTSO2; MGC23107; OTTHUMP00000032938; PKND; PYCD

Orthologs:

Mus musculus : Ctsk (cathepsin K) MGI
Rattus norvegicus : Ctsk (cathepsin K)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	1	157,270,298 - 157,282,531	-	NCBI
Human Genome Assembly HuRef	1	122,146,309 - 122,158,545	-	NCBI
Human Genome Assembly GRCh37	1	150,768,684 - 150,780,917	-	NCBI
Human Genome Assembly Build 36	1	149,035,311 - 149,047,436	-	NCBI
Human Cytogenetic Map	1	q21		NCBI
Human Genome Assembly	1	147,581,759 - 147,593,885		NCBI