GPI (glucose-6-phosphate isomerase)

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Keyword

Gene: GPI (glucose-6-phosphate isomerase) Homo sapiens

Symbol:

GPI

Name:

glucose-6-phosphate isomerase

Description:

This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

AMF; autocrine motility factor; DKFZp686C13233; glucose phosphate isomerase; glucose-6-phosphate isomerase; GNPI; hexose monophosphate isomerase; hexosephosphate isomerase; neuroleukin; NLK; oxoisomerase; PGI; PHI; phosphoglucose isomerase; phosphohexomutase; phosphohexose isomerase; phosphosaccharomutase; SA-36; SA36; sperm antigen 36; sperm antigen-36

Orthologs:

Mus musculus : Gpi1 (glucose phosphate isomerase 1) MGI
Rattus norvegicus : Gpi (glucose-6-phosphate isomerase)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	19	35,013,732 - 35,051,389	+	NCBI
Human Genome Assembly HuRef	19	31,360,777 - 31,377,222	+	NCBI
Human Genome Assembly HuRef	19	31,390,807 - 31,399,974	+	NCBI
Human Genome Assembly GRCh37	19	34,855,645 - 34,893,318	+	NCBI
Human Genome Assembly Build 36	19	39,547,909 - 39,583,076	+	NCBI
Human Cytogenetic Map	19	q13.1		NCBI
Human Genome Assembly	19	39,547,908 - 39,583,076		NCBI