RGD Reference Report - A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. - Rat Genome Database

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A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78.

Authors: Luo, Y  Long, JM  Lu, C  Chan, SL  Spangler, EL  Mascarucci, P  Raz, A  Longo, DL  Mattson, MP  Ingram, DK  Weng, NP 
Citation: Luo Y, etal., J Neurochem. 2002 Jan;80(2):354-61.
RGD ID: 1643424
Pubmed: PMID:11902125   (View Abstract at PubMed)

Neuroleukin (NLK) is a multifunctional protein involved in neuronal growth and survival, cell motility and differentiation, and glucose metabolism. We report herein that hippocampal expression of NLK and its receptor gp78 is associated with maze learning in rats. First, mRNA levels of NLK and gp78 were significantly increased in hippocampi of male Fischer-344 rats following training in the Stone T-maze and the Morris water maze. Second, a parallel increase was found in hippocampal NLK and gp78 proteins after maze learning. Third, NLK and gp78 mRNA and protein expression in hippocampus was reduced in a group of aged rats that showed more errors during the acquisition of the Stone maze task as compared with young rats. Finally, application of recombinant NLK to hippocampal neurons significantly enhanced glutamate-induced ion currents, functional molecular changes that have been correlated with learning in vivo. Taken together, our results identify a novel association of hippocampal expression of NLK and its receptor gp78 with rat maze learning. Interaction of NLK with gp78 and subsequent signaling may strengthen synaptic mechanisms underlying learning and memory formation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
learning or memory  IEP 1643424; 1643424 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Amfr  (autocrine motility factor receptor)
Gpi  (glucose-6-phosphate isomerase)


Additional Information