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The hexosamine biosynthetic pathway (HBP) results in the production of UDP-N-acetylglucosamine (UDP-GlcNAc) and other nucleotide hexosamines. UDP-GlcNAc, the major product, is the unique donor for the O-linkage of a single N-acetylglucosamine molecule (O-GlcNAc) to many cytoplasmic and nuclear proteins. Upon entering the cell glucose is rapidly phosphorylated to glucose-6-phosphate which can be oxidized via glycolysis or the pentose phosphate shunt or stored as glycogen. In glycolysis, G6P

Pathway Diagram:

Ariadne Genomics Inc. pentose phosphate pathway glycogen biosynthetic pathway fructose-6-phosphate G-Thr G-Ser O-GlcNac proteins Uap1 Mgea5 Ogt Pgm3 Gnpnat1 Gfpt1 acetyl-CoA glucose ---> glycogen biosynthetic pathway glucose glucose ---> glycolysis pathway glycolysis pathway glucose ---> pentose phosphate pathway N-acetylglucosamine UTP N-acetyl glucosamine-1-phosphate N-acetyl glucosamine-6-phosphate L-glutamine glucosamine-6-P UTP ---> N-acetylglucosamine N-acetyl glucosamine-6-phosphate ---> N-acetyl glucosamine-1-phosphate fructose-6-phosphate ---> glucosamine-6-P glucosamine-6-P ---> N-acetyl glucosamine-6-phosphate acetyl-CoA ---> N-acetyl glucosamine-6-phosphate N-acetylglucosamine ---> O-GlcNac proteins O-GlcNac proteins ---> proteins GlcNAc removed L-glutamine ---> glucosamine-6-P N-acetyl glucosamine-1-phosphate ---> N-acetylglucosamine proteins GlcNAc removed

Genes in Pathway:

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hexosamine biosynthetic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 GBrowse link 4 183,421,338 183,470,867 RGD:1625426
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 GBrowse link 15 23,685,448 23,698,244 RGD:1625539
G Gpi glucose-6-phosphate isomerase GBrowse link 1 91,207,014 91,234,890 RGD:1625539
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) GBrowse link 1 272,936,992 272,972,453 RGD:2311625
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link X 72,390,218 72,435,241 RGD:1625539
G Pgm3 phosphoglucomutase 3 GBrowse link 8 93,738,656 93,756,367 RGD:1625539
G Uap1 UDP-N-acteylglucosamine pyrophosphorylase 1 GBrowse link 13 93,089,458 93,123,827 RGD:1625539

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupO-GlcNAcylated proteinsseveral targets of O-GlcNAcylation

References Associated with the hexosamine biosynthetic pathway:

Ontology Path Diagram:

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