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The hexosamine biosynthetic pathway (HBP) results in the production of UDP-N-acetylglucosamine (UDP-GlcNAc) and other nucleotide hexosamines. UDP-GlcNAc, the major product, is the unique donor for the O-linkage of a single N-acetylglucosamine molecule (O-GlcNAc) to many cytoplasmic and nuclear proteins. Upon entering the cell glucose is rapidly phosphorylated to glucose-6-phosphate which can be oxidized via glycolysis or the pentose phosphate shunt or stored as glycogen. In glycolysis, G6P

Pathway Diagram:

Ariadne Genomics Inc. pentose phosphate pathway glycogen biosynthetic pathway fructose-6-phosphate G-Thr G-Ser O-GlcNac proteins Uap1 Mgea5 Ogt Pgm3 Gnpnat1 Gfpt1 acetyl-CoA glucose ---> glycogen biosynthetic pathway glucose glucose ---> glycolysis pathway glycolysis pathway glucose ---> pentose phosphate pathway N-acetylglucosamine UTP N-acetyl glucosamine-1-phosphate N-acetyl glucosamine-6-phosphate L-glutamine glucosamine-6-P UTP ---> N-acetylglucosamine N-acetyl glucosamine-6-phosphate ---> N-acetyl glucosamine-1-phosphate fructose-6-phosphate ---> glucosamine-6-P glucosamine-6-P ---> N-acetyl glucosamine-6-phosphate acetyl-CoA ---> N-acetyl glucosamine-6-phosphate N-acetylglucosamine ---> O-GlcNac proteins O-GlcNac proteins ---> proteins GlcNAc removed L-glutamine ---> glucosamine-6-P N-acetyl glucosamine-1-phosphate ---> N-acetylglucosamine proteins GlcNAc removed

Genes in Pathway:

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hexosamine biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 GBrowse link IMP 4 121,204,274 121,250,160 RGD:1625426 RGD
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 GBrowse link ISS 4 121,204,274 121,250,160 RGD:1625539 RGD
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 GBrowse link ISS 15 21,272,165 21,284,459 RGD:1625539 RGD
G Gpi glucose-6-phosphate isomerase GBrowse link ISS 1 86,658,836 86,686,712 RGD:1625539 RGD
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) GBrowse link TAS 1 250,966,386 251,000,363 RGD:2311625 RGD
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link ISS X 89,721,369 89,766,218 RGD:1625539 RGD
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link TAS X 89,721,369 89,766,218 RGD:2311625 RGD
G Pgm3 phosphoglucomutase 3 GBrowse link ISS 8 91,810,223 91,827,293 RGD:1625539 RGD
G Uap1 UDP-N-acteylglucosamine pyrophosphorylase 1 GBrowse link ISS 13 85,953,072 85,987,137 RGD:1625539 RGD

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupO-GlcNAcylated proteinsseveral targets of O-GlcNAcylation

Pathway Gene Annotations

Disease Annotations Associated with Genes in the hexosamine biosynthetic pathway
Disease TermsGene Symbols
Intellectual DisabilityGpi
Anemia, Hemolytic, CongenitalGpi
Diabetes Mellitus, Type 2Gfpt1
Neuromuscular DiseasesGpi
Uterine Cervical NeoplasmsPgm3
Insulin ResistanceGfpt1
Anemia, Hemolytic, Congenital NonspherocyticGpi
Diabetes Mellitus, ExperimentalGfpt1
Diabetic NephropathiesGfpt1
Reperfusion InjuryMgea5
Pathway Annotations Associated with Genes in the hexosamine biosynthetic pathway
Pathway TermsGene Symbols
glycolysis/gluconeogenesis pathwayGpi
alanine, aspartate and glutamate metabolic pathwayGfpt1
pentose phosphate pathwayGpi
nucleotide sugar metabolic pathwayGpi , Pgm3 , Gfpt1 , Gnpnat1 , Uap1
starch and sucrose metabolic pathwayGpi
amino sugar metabolic pathwayGpi , Pgm3 , Gfpt1 , Gnpnat1 , Uap1
O-linked glycan biosynthetic pathwayOgt
glycogen biosynthetic pathwayPgm3
glycogen degradation pathwayPgm3
hexosamine biosynthetic pathwayGpi , Ogt , Mgea5 , Pgm3 , Gfpt1 , Gnpnat1 , Uap1
glycolysis pathwayGpi
gluconeogenesis pathwayGpi

References Associated with the hexosamine biosynthetic pathway:

Ontology Path Diagram:

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