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The hexosamine biosynthetic pathway (HBP) results in the production of UDP-N-acetylglucosamine (UDP-GlcNAc) and other nucleotide hexosamines. UDP-GlcNAc, the major product, is the unique donor for the O-linkage of a single N-acetylglucosamine molecule (O-GlcNAc) to many cytoplasmic and nuclear proteins. Upon entering the cell glucose is rapidly phosphorylated to glucose-6-phosphate which can be oxidized via glycolysis or the pentose phosphate shunt or stored as glycogen. In glycolysis, G6P

Pathway Diagram:

Ariadne Genomics Inc. pentose phosphate pathway glycogen biosynthetic pathway fructose-6-phosphate G-Thr G-Ser O-GlcNac proteins Uap1 Mgea5 Ogt Pgm3 Gnpnat1 Gfpt1 acetyl-CoA glucose ---> glycogen biosynthetic pathway glucose glucose ---> glycolysis pathway glycolysis pathway glucose ---> pentose phosphate pathway N-acetylglucosamine UTP N-acetyl glucosamine-1-phosphate N-acetyl glucosamine-6-phosphate L-glutamine glucosamine-6-P UTP ---> N-acetylglucosamine N-acetyl glucosamine-6-phosphate ---> N-acetyl glucosamine-1-phosphate fructose-6-phosphate ---> glucosamine-6-P glucosamine-6-P ---> N-acetyl glucosamine-6-phosphate acetyl-CoA ---> N-acetyl glucosamine-6-phosphate N-acetylglucosamine ---> O-GlcNac proteins O-GlcNac proteins ---> proteins GlcNAc removed L-glutamine ---> glucosamine-6-P N-acetyl glucosamine-1-phosphate ---> N-acetylglucosamine proteins GlcNAc removed

Genes in Pathway:

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hexosamine biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 JBrowse link 4 118,852,046 118,901,583 RGD:1625426
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 JBrowse link 15 19,721,292 19,734,032 RGD:1625539
G Gpi glucose-6-phosphate isomerase JBrowse link 1 90,063,411 90,091,287 RGD:1625539
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) JBrowse link 1 265,506,752 265,542,452 RGD:2311625
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 71,540,870 71,585,906 RGD:1625539
G Pgm3 phosphoglucomutase 3 JBrowse link 8 94,225,513 94,243,230 RGD:1625539
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 JBrowse link 13 88,463,532 88,497,901 RGD:1625539

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupO-GlcNAcylated proteinsseveral targets of O-GlcNAcylation

Pathway Gene Annotations

Disease Annotations Associated with Genes in the hexosamine biosynthetic pathway
Pathway Annotations Associated with Genes in the hexosamine biosynthetic pathway
Pathway TermsGene Symbols
2-hydroxyglutaricaciduria disease pathwayGfpt1 , Gnpnat1
alanine, aspartate and glutamate metabolic pathwayGfpt1
amino sugar metabolic pathwayGfpt1 , Gnpnat1 , Gpi , Pgm3 , Uap1
DNA modification pathwayOgt
fanconi syndrome pathwayGpi
french type sialuria disease pathwayGfpt1 , Gnpnat1 , Pgm3 , Uap1
fructose-1,6-diphosphatase deficiency pathwayGpi
gluconeogenesis pathwayGpi
glutamic acid/glutamate metabolic pathwayGfpt1 , Gnpnat1
glycogen biosynthetic pathwayPgm3
glycogen degradation pathwayPgm3
glycogen storage disease pathway, type IAGpi
glycogen storage disease pathway, type IBGpi
glycogen storage disease pathway, type IIIGpi
glycogen storage disease pathway, type IV.Gpi
glycogen storage disease pathway, type VIGpi
glycogen storage disease pathway, type VIIGpi
glycolysis pathwayGpi
glycolysis/gluconeogenesis pathwayGpi
hexosamine biosynthetic pathwayGfpt1 , Gnpnat1 , Gpi , Mgea5 , Ogt , Pgm3 , Uap1
homocarnosinosis disease pathwayGfpt1 , Gnpnat1
nucleotide sugar metabolic pathwayGfpt1 , Gnpnat1 , Gpi , Pgm3 , Uap1
O-linked glycan biosynthetic pathwayOgt
pentose phosphate pathwayGpi
phosphoenolpyruvate carboxykinase deficiency pathwayGpi
ribose 5-phosphate isomerase deficiency pathwayGpi
sialic acid storage disease pathwayGfpt1 , Gnpnat1 , Pgm3 , Uap1
starch and sucrose metabolic pathwayGpi
succinic semialdehyde dehydrogenase deficiency pathwayGfpt1 , Gnpnat1
Sucrase-isomaltase deficiency pathwayGpi
Tay-Sachs disease pathwayGfpt1 , Gnpnat1 , Pgm3 , Uap1
transaldolase deficiency pathwayGpi
triosephosphate isomerase deficiency pathwayGpi

References Associated with the hexosamine biosynthetic pathway:

Ontology Path Diagram:

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Import into Pathway Studio: