A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.
hydrogenosome +
hydroxyisourate hydrolase complex
Ig heavy chain-bound endoplasmic reticulum chaperone complex
imidazoleglycerol-phosphate synthase complex
keratohyalin granule
large ribosomal subunit pre-assembly complex
membrane coat +
methane-oxidizing organelle
methionyl glutamyl tRNA synthetase complex
methylosome
microbody +
mitochondrial cloud
mitochondrial respiratory chain complex IV pre-assembly complex