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ONTOLOGY REPORT - ANNOTATIONS


Term:HSP90-CDC37 chaperone complex
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Accession:GO:1990565 term browser browse the term
Definition:A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.
Comment:An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).


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HSP90-CDC37 chaperone complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone part_of ISO
IEA
(PMID:21855797)
(MGI:5607224|PMID:21855797)
GO_REF:0000107
RGD
Ensembl
PMID:21855797 GO_REF:0000107 MGI:5607224 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 part_of ISO (PMID:21855797)
(MGI:5607224|PMID:21855797)
RGD PMID:21855797 MGI:5607224 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20010
    cellular anatomical entity 19714
      cytoplasm 11359
        HSP90-CDC37 chaperone complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20010
    cellular anatomical entity 19714
      intracellular anatomical structure 14388
        cytoplasm 11359
          HSP90-CDC37 chaperone complex 2
paths to the root