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ONTOLOGY REPORT - ANNOTATIONS


Term:HSP90-CDC37 chaperone complex
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Accession:GO:1990565 term browser browse the term
Definition:A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.
Comment:An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).
Synonyms:xref: IntAct:EBI-9990131;   IntAct:EBI-9990540


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HSP90-CDC37 chaperone complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291

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  cellular_component 20300
    intracellular 14243
      cytoplasm 11099
        HSP90-CDC37 chaperone complex 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.