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ONTOLOGY REPORT - ANNOTATIONS


Term:eukaryotic translation initiation factor 3 complex
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Accession:GO:0005852 term browser browse the term
Definition:A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Synonyms:exact_synonym: eIF-3;   eIF3


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eukaryotic translation initiation factor 3 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
G Eif3a eukaryotic translation initiation factor 3, subunit A JBrowse link 1 282,139,809 282,170,017 RGD:1624291
RGD:1600115
G Eif3b eukaryotic translation initiation factor 3, subunit B JBrowse link 12 16,285,730 16,310,190 RGD:1624291
RGD:13792537
RGD:1600115
G Eif3c eukaryotic translation initiation factor 3, subunit C JBrowse link 1 197,964,406 197,982,917 RGD:1624291
RGD:13792537
RGD:1600115
G Eif3d eukaryotic translation initiation factor 3, subunit D JBrowse link 7 119,188,189 119,200,578 RGD:1624291
RGD:13792537
RGD:1600115
G Eif3e eukaryotic translation initiation factor 3 subunit E JBrowse link 7 82,997,694 83,037,231 RGD:1624291
G Eif3el1 eukaryotic translation initiation factor 3, subunit E-like 1 JBrowse link 13 100,129,757 100,162,596 RGD:1600115
RGD:13792537
G Eif3f eukaryotic translation initiation factor 3, subunit F JBrowse link 1 173,532,826 173,541,806 RGD:1624291
G Eif3g eukaryotic translation initiation factor 3, subunit G JBrowse link 8 21,911,632 21,915,664 RGD:1624291
RGD:1600115
G Eif3h eukaryotic translation initiation factor 3, subunit H JBrowse link 6 10,151,732 10,236,677 RGD:1624291
RGD:13792537
RGD:1600115
G Eif3i eukaryotic translation initiation factor 3, subunit I JBrowse link 5 147,796,580 147,803,853 RGD:1624291
RGD:1600115
G Eif3j eukaryotic translation initiation factor 3, subunit J JBrowse link 3 113,976,687 113,998,925 RGD:1600115
RGD:13792537
RGD:1624291
G Eif3k eukaryotic translation initiation factor 3, subunit K JBrowse link 1 87,927,142 87,937,033 RGD:1624291
RGD:13792537
G Eif3l eukaryotic translation initiation factor 3, subunit L JBrowse link 7 120,320,547 120,331,596 RGD:1624291
RGD:13792537
G Eif3m eukaryotic translation initiation factor 3, subunit M JBrowse link 3 94,990,086 95,007,690 RGD:1624291
RGD:13792537
G LOC100365062 eukaryotic translation initiation factor 3, subunit 6 48kDa-like JBrowse link 1 66,643,731 66,645,224 RGD:13792537
G LOC100909481 eukaryotic translation initiation factor 3 subunit E-like JBrowse link 1 66,637,810 66,639,219 RGD:13792537
G LOC108348062 eukaryotic translation initiation factor 3 subunit H JBrowse link 6 108,698,680 108,756,289 RGD:1600115
RGD:13792537
G LOC108348260 eukaryotic translation initiation factor 3 subunit E RGD:1600115
RGD:13792537
eukaryotic translation initiation factor 3 complex, eIF3e term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif3a eukaryotic translation initiation factor 3, subunit A JBrowse link 1 282,139,809 282,170,017 RGD:13792537
G Eif3el1 eukaryotic translation initiation factor 3, subunit E-like 1 JBrowse link 13 100,129,757 100,162,596 RGD:1600115
G LOC100365062 eukaryotic translation initiation factor 3, subunit 6 48kDa-like JBrowse link 1 66,643,731 66,645,224 RGD:1600115
G LOC100909481 eukaryotic translation initiation factor 3 subunit E-like JBrowse link 1 66,637,810 66,639,219 RGD:1600115
G LOC108348260 eukaryotic translation initiation factor 3 subunit E RGD:1600115
eukaryotic translation initiation factor 3 complex, eIF3m term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif3a eukaryotic translation initiation factor 3, subunit A JBrowse link 1 282,139,809 282,170,017 RGD:1624291
RGD:13792537
G Eif3b eukaryotic translation initiation factor 3, subunit B JBrowse link 12 16,285,730 16,310,190 RGD:1624291
G Eif3c eukaryotic translation initiation factor 3, subunit C JBrowse link 1 197,964,406 197,982,917 RGD:1624291
G Eif3d eukaryotic translation initiation factor 3, subunit D JBrowse link 7 119,188,189 119,200,578 RGD:1624291
G Eif3f eukaryotic translation initiation factor 3, subunit F JBrowse link 1 173,532,826 173,541,806 RGD:1624291
RGD:13792537
G Eif3h eukaryotic translation initiation factor 3, subunit H JBrowse link 6 10,151,732 10,236,677 RGD:1624291
G Eif3i eukaryotic translation initiation factor 3, subunit I JBrowse link 5 147,796,580 147,803,853 RGD:1624291
RGD:13792537
G Eif3m eukaryotic translation initiation factor 3, subunit M JBrowse link 3 94,990,086 95,007,690 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20118
    protein-containing complex 5964
      eukaryotic translation initiation factor 3 complex 19
        eukaryotic translation initiation factor 3 complex, eIF3e 5
        eukaryotic translation initiation factor 3 complex, eIF3m 8
Path 2
Term Annotations click to browse term
  cellular_component 20118
    intracellular 14088
      cytoplasm 10968
        eukaryotic translation initiation factor 3 complex 19
          eukaryotic translation initiation factor 3 complex, eIF3e 5
          eukaryotic translation initiation factor 3 complex, eIF3m 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.