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ONTOLOGY REPORT - ANNOTATIONS


Term:eukaryotic translation initiation factor 3 complex
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Accession:GO:0005852 term browser browse the term
Definition:A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Synonyms:exact_synonym: eIF-3;   eIF3


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eukaryotic translation initiation factor 3 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3, X-linked colocalizes_with ISO (PMID:18628297) RGD PMID:18628297 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A part_of ISO
ISS
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
(MGI:3843422|PMID:17581632)
GO_REF:0000024
RGD
UniProt
PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773 GO_REF:0000024 MGI:3843422 NCBI chr 1:282,139,809...282,170,017
Ensembl chr 1:282,139,823...282,170,017
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B part_of ISS
ISO
IBA
GO_REF:0000024
(MGI:3843422|PMID:17581632)
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773), (PMID:8995410)
PMID:21873635
UniProt
RGD
PMID:8995410 PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773, PMID:21873635 GO_REF:0000024 MGI:3843422, RGD:13792537 NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C part_of ISO
IBA
ISS
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
(MGI:3843422|PMID:17581632)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773, PMID:21873635 GO_REF:0000024 MGI:3843422, RGD:13792537 NCBI chr 1:197,964,406...197,982,917
Ensembl chr 1:197,964,407...197,982,601
JBrowse link
G Eif3d eukaryotic translation initiation factor 3, subunit D part_of IBA
ISO
ISS
PMID:21873635
(MGI:3843422|PMID:17581632)
GO_REF:0000024
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773), (PMID:27462815)
RGD
UniProt
PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773 PMID:27462815, PMID:21873635 GO_REF:0000024 MGI:3843422, RGD:13792537 NCBI chr 7:119,188,189...119,200,578
Ensembl chr 7:119,188,185...119,200,623
JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E part_of ISO (PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773), (PMID:9295280)
(MGI:3843422|PMID:17581632)
RGD PMID:9295280 PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773 MGI:3843422 NCBI chr 7:82,997,694...83,037,231 JBrowse link
G Eif3el1 eukaryotic translation initiation factor 3, subunit E-like 1 part_of ISS
IBA
GO_REF:0000024
PMID:21873635
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:100,129,757...100,162,596
Ensembl chr13:100,129,761...100,162,461
JBrowse link
G Eif3f eukaryotic translation initiation factor 3, subunit F part_of ISO (PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
(MGI:3843422|PMID:17581632)
RGD PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773 MGI:3843422 NCBI chr 1:173,532,826...173,541,806
Ensembl chr 1:173,532,803...173,541,847
JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G part_of ISO
ISS
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
(MGI:3843422|PMID:17581632)
GO_REF:0000024
RGD
UniProt
PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773 GO_REF:0000024 MGI:3843422 NCBI chr 8:21,911,632...21,915,664
Ensembl chr 8:21,911,625...21,915,716
JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H part_of IBA
ISO
ISS
PMID:21873635
(MGI:3843422|PMID:17581632)
GO_REF:0000024
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
RGD
UniProt
PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773, PMID:21873635 GO_REF:0000024 MGI:3843422, RGD:13792537 NCBI chr 6:10,151,732...10,236,677
Ensembl chr 6:10,151,729...10,236,695
Ensembl chr 6:10,151,729...10,236,695
Ensembl chr 6:10,151,729...10,236,695
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I part_of ISO
ISS
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
(MGI:3843422|PMID:17581632)
GO_REF:0000024
RGD
UniProt
PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773 GO_REF:0000024 MGI:3843422 NCBI chr 5:147,796,580...147,803,853
Ensembl chr 5:147,796,662...147,803,851
JBrowse link
G Eif3j eukaryotic translation initiation factor 3, subunit J part_of IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:17322308), (PMID:18599441)
UniProt
RGD
PMID:17322308 PMID:18599441, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:113,976,687...113,998,925
Ensembl chr 3:113,976,687...113,998,922
JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K part_of IBA
ISO
PMID:21873635
(MGI:3843422|PMID:17581632)
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
RGD PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773, PMID:21873635 MGI:3843422, RGD:13792537 NCBI chr 1:87,927,142...87,937,033
Ensembl chr 1:87,927,141...87,937,516
JBrowse link
G Eif3l eukaryotic translation initiation factor 3, subunit L part_of IBA
ISO
PMID:21873635
(MGI:3843422|PMID:17581632)
(PMID:17322308), (PMID:17581632), (PMID:18599441), (PMID:25849773)
RGD PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773, PMID:21873635 MGI:3843422, RGD:13792537 NCBI chr 7:120,320,547...120,331,596
Ensembl chr 7:120,320,547...120,331,595
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M part_of ISO
IBA
(PMID:17322308), (PMID:18599441), (PMID:25849773)
PMID:21873635
RGD PMID:17322308 PMID:18599441 PMID:25849773, PMID:21873635 RGD:13792537 NCBI chr 3:94,990,086...95,007,690
Ensembl chr 3:94,990,068...95,007,712
JBrowse link
G LOC100365062 eukaryotic translation initiation factor 3, subunit 6 48kDa-like part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:66,643,731...66,645,224
Ensembl chr 1:66,643,739...66,645,214
Ensembl chr 1:66,643,739...66,645,214
JBrowse link
G LOC108348260 eukaryotic translation initiation factor 3 subunit E part_of ISS
IBA
GO_REF:0000024
PMID:21873635
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537
eukaryotic translation initiation factor 3 complex, eIF3e term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif3a eukaryotic translation initiation factor 3, subunit A part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:282,139,809...282,170,017
Ensembl chr 1:282,139,823...282,170,017
JBrowse link
G Eif3el1 eukaryotic translation initiation factor 3, subunit E-like 1 part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:100,129,757...100,162,596
Ensembl chr13:100,129,761...100,162,461
JBrowse link
G LOC100365062 eukaryotic translation initiation factor 3, subunit 6 48kDa-like part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:66,643,731...66,645,224
Ensembl chr 1:66,643,739...66,645,214
Ensembl chr 1:66,643,739...66,645,214
JBrowse link
G LOC108348260 eukaryotic translation initiation factor 3 subunit E part_of IEA GO_REF:0000104 UniProt GO_REF:0000104
eukaryotic translation initiation factor 3 complex, eIF3m term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif3a eukaryotic translation initiation factor 3, subunit A part_of IBA
ISO
PMID:21873635
(MGI:5543727|PMID:24003236)
RGD PMID:24003236, PMID:21873635 MGI:5543727, RGD:13792537 NCBI chr 1:282,139,809...282,170,017
Ensembl chr 1:282,139,823...282,170,017
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B part_of ISO (MGI:5543727|PMID:24003236) RGD PMID:24003236 MGI:5543727 NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C part_of ISO (MGI:5543727|PMID:24003236) RGD PMID:24003236 MGI:5543727 NCBI chr 1:197,964,406...197,982,917
Ensembl chr 1:197,964,407...197,982,601
JBrowse link
G Eif3d eukaryotic translation initiation factor 3, subunit D part_of ISO (MGI:5543727|PMID:24003236) RGD PMID:24003236 MGI:5543727 NCBI chr 7:119,188,189...119,200,578
Ensembl chr 7:119,188,185...119,200,623
JBrowse link
G Eif3f eukaryotic translation initiation factor 3, subunit F part_of IBA
ISO
PMID:21873635
(MGI:5543727|PMID:24003236)
RGD PMID:24003236, PMID:21873635 MGI:5543727, RGD:13792537 NCBI chr 1:173,532,826...173,541,806
Ensembl chr 1:173,532,803...173,541,847
JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H part_of ISO (MGI:5543727|PMID:24003236) RGD PMID:24003236 MGI:5543727 NCBI chr 6:10,151,732...10,236,677
Ensembl chr 6:10,151,729...10,236,695
Ensembl chr 6:10,151,729...10,236,695
Ensembl chr 6:10,151,729...10,236,695
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I part_of IBA
ISO
PMID:21873635
(MGI:5543727|PMID:24003236)
RGD PMID:24003236, PMID:21873635 MGI:5543727, RGD:13792537 NCBI chr 5:147,796,580...147,803,853
Ensembl chr 5:147,796,662...147,803,851
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M part_of ISO (MGI:5543727|PMID:24003236) RGD PMID:24003236 MGI:5543727 NCBI chr 3:94,990,086...95,007,690
Ensembl chr 3:94,990,068...95,007,712
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20138
    protein-containing complex 6037
      eukaryotic translation initiation factor 3 complex 17
        eukaryotic translation initiation factor 3 complex, eIF3e 4
        eukaryotic translation initiation factor 3 complex, eIF3m 8
Path 2
Term Annotations click to browse term
  cellular_component 20138
    cellular anatomical entity 19840
      intracellular anatomical structure 14441
        cytoplasm 11424
          eukaryotic translation initiation factor 3 complex 17
            eukaryotic translation initiation factor 3 complex, eIF3e 4
            eukaryotic translation initiation factor 3 complex, eIF3m 8
paths to the root