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Accession:GO:0002096 term browser browse the term
Definition:A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.
Comment:Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots.

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polkadots term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10, immune signaling adaptor ISO (MGI:MGI:3656456|PMID:16495340) RGD PMID:16495340 MGI:MGI:3656456 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Malt1 MALT1 paracaspase ISO (MGI:MGI:3656456|PMID:16495340) RGD PMID:16495340 MGI:MGI:3656456 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      polkadots 2
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        cytoplasm 11456
          polkadots 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.