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ONTOLOGY REPORT - ANNOTATIONS


Term:methylosome
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Accession:GO:0034709 term browser browse the term
Definition:A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
Synonyms:exact_synonym: 20S methylosome;   20S methyltransferase complex


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methylosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clns1a chloride nucleotide-sensitive channel 1A part_of ISS
ISO
IEA
GO_REF:0000024
(PMID:18984161)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:18984161 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:162,676,246...162,696,549
Ensembl chr 1:162,676,269...162,696,544
JBrowse link
G Erh ERH, mRNA splicing and mitosis factor part_of ISO (PMID:25284789) RGD PMID:25284789 NCBI chr 6:104,280,390...104,290,905
Ensembl chr 6:104,280,408...104,290,579
JBrowse link
G Prmt1 protein arginine methyltransferase 1 part_of ISO
ISS
(PMID:25284789)
GO_REF:0000024
RGD
UniProt
PMID:25284789 GO_REF:0000024 NCBI chr 1:100,971,132...100,980,411
Ensembl chr 1:100,971,273...100,980,340
JBrowse link
G Prmt5 protein arginine methyltransferase 5 part_of ISO (PMID:18984161), (PMID:25284789) RGD PMID:18984161 PMID:25284789 NCBI chr15:33,156,508...33,165,893
Ensembl chr15:33,156,492...33,165,895
JBrowse link
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 part_of ISO
ISS
(PMID:18984161)
GO_REF:0000024
RGD
UniProt
PMID:18984161 GO_REF:0000024 NCBI chr 3:122,696,125...122,703,734
Ensembl chr 3:122,695,939...122,703,734
JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide part_of ISO (PMID:18984161) RGD PMID:18984161 NCBI chr18:1,866,066...1,876,613
Ensembl chr18:1,866,080...1,876,613
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide part_of ISO (PMID:18984161) RGD PMID:18984161 NCBI chr 1:80,057,140...80,059,990
Ensembl chr 1:80,056,755...80,059,996
JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide part_of ISO (PMID:18984161) RGD PMID:18984161 NCBI chr20:14,080,562...14,095,644
Ensembl chr20:14,080,565...14,095,181
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E part_of ISO (PMID:18984161) RGD PMID:18984161 NCBI chr13:50,252,707...50,258,951
Ensembl chr 8:129,371,556...129,371,973
JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F part_of ISO (PMID:18984161) RGD PMID:18984161 NCBI chr 7:34,478,331...34,485,034
Ensembl chr 7:34,478,331...34,485,034
JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G part_of ISO (PMID:18984161) RGD PMID:18984161 NCBI chr 4:118,167,267...118,174,846
Ensembl chr 4:118,167,294...118,174,842
JBrowse link
G Wdr77 WD repeat domain 77 part_of IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:18984161), (PMID:25284789)
UniProt
RGD
PMID:18984161 PMID:25284789, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:208,577,292...208,587,263
Ensembl chr 2:208,420,309...208,587,260
Ensembl chr 2:208,420,309...208,587,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20138
    cellular anatomical entity 19840
      cytoplasm 11424
        methylosome 12
Path 2
Term Annotations click to browse term
  cellular_component 20138
    protein-containing complex 6037
      catalytic complex 1457
        transferase complex 800
          methyltransferase complex 95
            methylosome 12
paths to the root