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ONTOLOGY REPORT - ANNOTATIONS

Term:cytoplasmic exosome (RNase complex)
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Accession:GO:0000177 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms:exact_synonym: cytoplasmic exosome (ribonuclease complex);   cytoplasmic exosome multienzyme ribonuclease complex;   prokaryotic exosome multienzyme ribonuclease complex


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cytoplasmic exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carhsp1 calcium regulated heat stable protein 1 located_in
part_of		 ISS
ISO		 GO_REF:0000024
(PMID:21078874)		 UniProt
RGD		 PMID:21078874 GO_REF:0000024 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019 		JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:82,231,922...82,258,299
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Dis3l DIS3-like exosome 3'-5' exoribonuclease part_of ISO
ISS
IBA
IEA		 (PMID:20531386), (PMID:20531389)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000107		 RGD
UniProt
GO_Central
Ensembl		 PMID:20531386 PMID:20531389 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:73,699,185...73,735,581
Ensembl chr 8:64,803,927...64,840,165 		JBrowse link
G Exosc2 exosome component 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:35,360,652...35,370,948
Ensembl chr 3:14,962,917...14,973,575 		JBrowse link
G Exosc3 exosome component 3 part_of ISO
IBA
IEA		 (PMID:11110791)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:11110791 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc4 exosome component 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G Exosc5 exosome component 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265 		JBrowse link
G Exosc6 exosome component 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Exosc7 exosome component 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270 		JBrowse link
G Exosc8 exosome component 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928 		JBrowse link
G Exosc9 exosome component 9 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051 		JBrowse link
G Gtpbp1 GTP binding protein 1 part_of IDA PMID:21515746 UniProt PMID:21515746 RGD:8553842 NCBI chr 7:111,248,254...111,272,705
Ensembl chr 7:111,248,254...111,272,705 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21366
    cellular anatomical structure 21071
      cytoplasm 12301
        cytoplasmic exosome (RNase complex) 12
          bacterial degradosome 0
Path 2
Term Annotations click to browse term
  cellular_component 21366
    protein-containing complex 6834
      catalytic complex 1961
        exoribonuclease complex 25
          exosome (RNase complex) 20
            cytoplasmic exosome (RNase complex) 12
              bacterial degradosome 0
paths to the root