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ONTOLOGY REPORT - ANNOTATIONS


Term:nitric oxide biosynthetic process
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Accession:GO:0006809 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
Synonyms:exact_synonym: nitric oxide anabolism;   nitric oxide biosynthesis;   nitric oxide formation;   nitric oxide synthesis


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nitric oxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant acts_upstream_of ISO (PMID:11168643) MGI PMID:11168643 NCBI chrNW_004955495:2,418,113...2,421,181
Ensembl chrNW_004955495:2,418,364...2,421,538
JBrowse link
G Cav1 caveolin 1 acts_upstream_of ISO (PMID:12388077) MGI PMID:12388077 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403
JBrowse link
G Ifng interferon gamma acts_upstream_of ISO (PMID:11168643) MGI PMID:11168643 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G LOC102009223 cytochrome P450 1B1 involved_in ISO (MGI:4431324|PMID:20032512) UniProt PMID:20032512 MGI:4431324 NCBI chrNW_004955441:5,803,397...5,812,131
Ensembl chrNW_004955441:5,803,032...5,812,131
JBrowse link
G LOC102012303 NADH-cytochrome b5 reductase 3 involved_in ISO (PMID:24500710) FlyBase PMID:24500710 NCBI chrNW_004955413:27,971,140...27,979,905
Ensembl chrNW_004955413:27,969,949...27,979,909
JBrowse link
G LOC102026979 cytochrome b5 type B involved_in ISO (PMID:24500710) FlyBase PMID:24500710 NCBI chrNW_004955484:7,239,364...7,270,639
Ensembl chrNW_004955484:7,237,906...7,271,123
JBrowse link
G Nos1 nitric oxide synthase 1 involved_in ISO (MGI:3807771|PMID:7545544), (MGI:5582183|PMID:11591728)
PMID:1383204
RGD
BHF-UCL
PMID:1383204 PMID:7545544 PMID:11591728 PMID:14966111 MGI:3807771 MGI:5582183 RGD:1358520 RGD:8553334 NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566
JBrowse link
G Nos2 nitric oxide synthase 2 involved_in ISO (MGI:3807769|PMID:9271491), (MGI:3807772|PMID:1383204)
(PMID:7504305), (PMID:7682706)
RGD
BHF-UCL
UniProt
PMID:1383204 PMID:7504305 PMID:7682706 PMID:9271491 PMID:12826065 More... MGI:3807769 MGI:3807772 RGD:1358527 RGD:1580262 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
JBrowse link
G Nos3 nitric oxide synthase 3 acts_upstream_of_or_within
involved_in
ISO (PMID:15647265)
(PMID:1378832), (PMID:7488039)
RGD
MGI
BHF-UCL
PMID:1378832 PMID:7488039 PMID:12388111 PMID:15647265 PMID:16344378 RGD:628542 RGD:7794722 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
JBrowse link
G P2rx4 purinergic receptor P2X 4 acts_upstream_of_or_within ISO (PMID:16327800) MGI PMID:16327800 NCBI chrNW_004955482:7,031,874...7,039,026
Ensembl chrNW_004955482:7,031,874...7,039,220
JBrowse link
G Rora RAR related orphan receptor A acts_upstream_of_or_within ISO (PMID:7518067) MGI PMID:7518067 NCBI chrNW_004955450:14,262,199...14,434,611
Ensembl chrNW_004955450:14,262,190...14,425,233
JBrowse link
G Slc7a2 solute carrier family 7 member 2 acts_upstream_of_or_within ISO (PMID:12675924) MGI PMID:12675924 NCBI chrNW_004955552:2,117,972...2,141,144
Ensembl chrNW_004955552:2,117,755...2,141,231
JBrowse link
G Slc7a6 solute carrier family 7 member 6 involved_in ISO PMID:26448619 UniProt PMID:26448619 RGD:11531816 NCBI chrNW_004955484:8,335,508...8,383,814
Ensembl chrNW_004955484:8,349,622...8,383,475
JBrowse link
G Spr sepiapterin reductase involved_in ISO (PMID:15197144) UniProt PMID:15197144 NCBI chrNW_004955424:12,711,064...12,716,000
Ensembl chrNW_004955424:12,711,064...12,716,000
JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 acts_upstream_of ISO (PMID:12872135) MGI PMID:12872135 NCBI chrNW_004955495:4,197,083...4,204,999
Ensembl chrNW_004955495:4,202,372...4,204,513
JBrowse link
G Tlr2 toll like receptor 2 acts_upstream_of ISO (PMID:10549626), (PMID:16239543) MGI PMID:10549626 PMID:16239543 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr4 toll like receptor 4 acts_upstream_of ISO (PMID:10549626) MGI PMID:10549626 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
negative regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant acts_upstream_of_or_within ISO (PMID:11168643) MGI PMID:11168643 NCBI chrNW_004955495:2,418,113...2,421,181
Ensembl chrNW_004955495:2,418,364...2,421,538
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:11591728), (PMID:17242280), (PMID:19278978) BHF-UCL PMID:11591728 PMID:17242280 PMID:19278978 NCBI chrNW_004955406:39,552,034...39,645,694
Ensembl chrNW_004955406:39,552,019...39,645,694
JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within ISO (PMID:12388077) MGI PMID:12388077 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403
JBrowse link
G Dynll1 dynein light chain LC8-type 1 acts_upstream_of_or_within
involved_in
ISO PMID:8864115 MGI
UniProt
PMID:8864115 RGD:633683 NCBI chrNW_004955455:11,148,041...11,150,860
Ensembl chrNW_004955455:11,148,047...11,150,859
JBrowse link
G Epor erythropoietin receptor ISO RGD PMID:10489101 RGD:11041656 NCBI chrNW_004955495:2,293,587...2,299,302
Ensembl chrNW_004955495:2,293,540...2,298,715
JBrowse link
G Gla galactosidase alpha involved_in ISO (MGI:3624267|PMID:15668341) UniProt PMID:15668341 MGI:3624267 NCBI chrNW_004955503:7,526,077...7,535,817
Ensembl chrNW_004955503:7,521,930...7,535,817
JBrowse link
G Il10 interleukin 10 ISO RGD PMID:17017555 RGD:1598631 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Il4 interleukin 4 ISO RGD PMID:18182309 RGD:2317291 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Khsrp KH-type splicing regulatory protein involved_in ISO (PMID:16126846) UniProt PMID:16126846 NCBI chrNW_004955495:3,183,083...3,194,356
Ensembl chrNW_004955495:3,183,179...3,193,376
JBrowse link
G Oprm1 opioid receptor mu 1 involved_in ISO (PMID:20525224) UniProt PMID:20525224 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817
JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004955483:4,495,257...4,503,377 JBrowse link
G Ptgis prostaglandin I2 synthase involved_in ISO (PMID:20159982) UniProt PMID:20159982 NCBI chrNW_004955445:8,624,228...8,663,385
Ensembl chrNW_004955445:8,623,430...8,677,658
JBrowse link
G Rgn regucalcin ISO RGD PMID:12686401 RGD:9590175 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910
JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:29353861)
(MGI:6271078|PMID:29353861)
ARUK-UCL PMID:29353861 MGI:6271078 NCBI chrNW_004955487:5,856,190...5,972,408
Ensembl chrNW_004955487:5,859,204...5,972,401
JBrowse link
G Sirpa signal regulatory protein alpha involved_in ISO (MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:3760575 NCBI chrNW_004955415:13,030,752...13,072,735 JBrowse link
G Tspo translocator protein ISO RGD PMID:14678758 RGD:2317158 NCBI chrNW_004955413:28,309,105...28,315,075
Ensembl chrNW_004955413:28,308,658...28,315,075
JBrowse link
G Wdr35 WD repeat domain 35 ISO RGD PMID:18671723 RGD:11553926 NCBI chrNW_004955469:2,484,972...2,546,562
Ensembl chrNW_004955469:2,482,353...2,546,578
JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in ISO (PMID:18178554)
(MGI:5142149|PMID:21616078)
BHF-UCL
UniProt
PMID:18178554 PMID:21616078 MGI:5142149 NCBI chrNW_004955452:15,306,398...15,314,959
Ensembl chrNW_004955452:15,305,775...15,314,959
JBrowse link
positive regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:17616753 RGD:8548892 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357
JBrowse link
G Agxt2 alanine--glyoxylate aminotransferase 2 involved_in ISO (PMID:20018850) BHF-UCL PMID:20018850 NCBI chrNW_004955426:20,102,368...20,142,596
Ensembl chrNW_004955426:20,101,620...20,142,620
JBrowse link
G Aif1 allograft inflammatory factor 1 ISO RGD PMID:16157606 RGD:2313017 NCBI chrNW_004955437:157,509...158,919 JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:10376603) BHF-UCL PMID:10376603 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:18335029 RGD:2313325 NCBI chrNW_004955578:950,258...1,004,438
Ensembl chrNW_004955578:967,593...1,004,438
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:8995232) BHF-UCL PMID:8995232 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Asl argininosuccinate lyase involved_in ISO (PMID:22081021)
(MGI:5305859|PMID:22081021)
UniProt PMID:22081021 MGI:5305859 NCBI chrNW_004955456:8,409,767...8,419,915
Ensembl chrNW_004955456:8,411,220...8,416,992
JBrowse link
G Ass1 argininosuccinate synthase 1 involved_in ISO (PMID:21106532) BHF-UCL PMID:21106532 NCBI chrNW_004955513:443,372...485,190
Ensembl chrNW_004955513:445,462...485,190
JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
JBrowse link
G Clu clusterin involved_in ISO (PMID:15857407) Alzheimers_University_of_Toronto PMID:15857407 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 involved_in ISO (MGI:5315329|PMID:21493890) RGD
BHF-UCL
PMID:12237779 PMID:21493890 MGI:5315329 RGD:727432 NCBI chrNW_004955423:8,637,116...8,673,881
Ensembl chrNW_004955423:8,636,756...8,676,790
JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:16973909 RGD:9685181 NCBI chrNW_004955495:1,860,644...1,934,589
Ensembl chrNW_004955495:1,860,644...1,934,818
JBrowse link
G Esr1 estrogen receptor 1 involved_in ISO (PMID:21937726) UniProt PMID:21937726 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
JBrowse link
G Hrh1 histamine receptor H1 ISO RGD PMID:12419527 RGD:727463 NCBI chrNW_004955429:14,022,332...14,069,931
Ensembl chrNW_004955429:14,067,405...14,068,853
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in ISO (MGI:3687888|PMID:12855682) UniProt PMID:12855682 MGI:3687888 NCBI chrNW_004955538:1,469,544...1,475,010
Ensembl chrNW_004955538:1,469,544...1,475,019
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:9062344 RGD:1600239 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
JBrowse link
G Ifng interferon gamma involved_in
acts_upstream_of_or_within
ISO (PMID:8383325)
(PMID:11168643)
BHF-UCL
MGI
PMID:8383325 PMID:11168643 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:8383325) BHF-UCL PMID:8383325 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
G Il6 interleukin 6 ISO RGD PMID:15845578 RGD:2306941 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Insr insulin receptor involved_in ISO (PMID:10747347) BHF-UCL PMID:10747347 NCBI chrNW_004955563:1,867,400...2,011,845
Ensembl chrNW_004955563:1,867,400...2,009,149
JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:9062344 RGD:1600239 NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:12595539 RGD:1641934 NCBI chrNW_004955434:9,227,897...9,341,208
Ensembl chrNW_004955434:9,227,595...9,341,208
JBrowse link
G Klf4 KLF transcription factor 4 involved_in ISO (PMID:22430140) BHF-UCL PMID:22430140 NCBI chrNW_004955419:19,280,311...19,284,097
Ensembl chrNW_004955419:19,280,235...19,285,174
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:10593906 RGD:2304240 NCBI chrNW_004955408:391,094...430,638
Ensembl chrNW_004955408:391,094...430,981
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:19576187 RGD:10041012 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694
JBrowse link
G Nfatc3 nuclear factor of activated T cells 3 involved_in ISO (MGI:6871969|PMID:24970700) UniProt PMID:24970700 MGI:6871969 NCBI chrNW_004955484:8,433,765...8,558,005
Ensembl chrNW_004955484:8,436,330...8,526,680
JBrowse link
G Oprm1 opioid receptor mu 1 involved_in ISO (PMID:20214800) UniProt PMID:20214800 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta acts_upstream_of_or_within ISO (PMID:18558630) BHF-UCL PMID:18558630 NCBI chrNW_004955501:251,829...381,255
Ensembl chrNW_004955501:259,645...379,909
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel involved_in ISO (PMID:19265036)
(MGI:5315687|PMID:19265036)
BHF-UCL PMID:19265036 MGI:5315687 NCBI chrNW_004955474:1,831,221...1,868,170
Ensembl chrNW_004955474:1,833,701...1,868,817
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO RGD PMID:21926342 RGD:10041069 NCBI chrNW_004955403:49,856,056...49,970,800
Ensembl chrNW_004955403:49,855,541...49,973,225
JBrowse link
G Ptx3 pentraxin 3 acts_upstream_of_or_within ISO (PMID:14726497) MGI PMID:14726497 NCBI chrNW_004955448:8,366,795...8,373,010
Ensembl chrNW_004955448:8,366,925...8,372,411
JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:27038547) BHF-UCL PMID:27038547 RGD:11535100 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO RGD PMID:14720208 RGD:10042970 NCBI chrNW_004955484:8,207,686...8,298,164
Ensembl chrNW_004955484:8,272,572...8,298,144
JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO (PMID:15637112) MGI PMID:15637112 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 acts_upstream_of_or_within ISO (PMID:12872135) MGI PMID:12872135 NCBI chrNW_004955495:4,197,083...4,204,999
Ensembl chrNW_004955495:4,202,372...4,204,513
JBrowse link
G Tlr2 toll like receptor 2 acts_upstream_of_or_within ISO (PMID:10549626), (PMID:16239543) MGI PMID:10549626 PMID:16239543 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr4 toll like receptor 4 involved_in
acts_upstream_of_or_within
ISO (MGI:4438693|PMID:20037584)
(PMID:10549626)
ARUK-UCL
MGI
PMID:10549626 PMID:20037584 MGI:4438693 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tlr5 toll like receptor 5 ISO RGD PMID:16973131 RGD:1643119 NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093
JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:8383325) BHF-UCL PMID:8383325 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO RGD PMID:16081483 RGD:2317115 NCBI chrNW_004955467:13,221,391...13,239,089
Ensembl chrNW_004955467:13,221,391...13,239,089
JBrowse link
regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2a activin A receptor type 2A acts_upstream_of_or_within ISO (PMID:16093358) MGI PMID:16093358 NCBI chrNW_004955440:13,849,926...13,931,374
Ensembl chrNW_004955440:13,849,926...13,931,374
JBrowse link
G Arg2 arginase 2 ISO RGD PMID:11829529 RGD:634667 NCBI chrNW_004955466:2,549,557...2,577,060
Ensembl chrNW_004955466:2,549,557...2,577,060
JBrowse link
G Cd47 CD47 molecule involved_in ISO (MGI:6201986|PMID:16055727) ARUK-UCL PMID:16055727 MGI:6201986 NCBI chrNW_004955427:8,704,519...8,740,962 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in ISO (MGI:6162390|PMID:23499256) ARUK-UCL PMID:23499256 MGI:6162390 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
JBrowse link
G Igf1 insulin like growth factor 1 acts_upstream_of_or_within ISO (PMID:21677284) MGI PMID:21677284 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
JBrowse link
G Jak2 Janus kinase 2 involved_in ISO PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chrNW_004955434:9,227,897...9,341,208
Ensembl chrNW_004955434:9,227,595...9,341,208
JBrowse link
G Nosip nitric oxide synthase interacting protein involved_in ISO (PMID:15548660) UniProt PMID:15548660 NCBI chrNW_004955559:1,287,155...1,300,550
Ensembl chrNW_004955559:1,297,340...1,300,507
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Sirpa signal regulatory protein alpha involved_in ISO PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chrNW_004955415:13,030,752...13,072,735 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 12352
    metabolic process 7468
      biosynthetic process 5310
        nitric oxide biosynthetic process 78
          negative regulation of nitric oxide biosynthetic process 18
          positive regulation of nitric oxide biosynthetic process 43
          regulation of nitric oxide biosynthetic process + 67
Path 2
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  biological_process 12352
    metabolic process 7468
      reactive nitrogen species metabolic process 91
        nitric oxide metabolic process 89
          nitric oxide biosynthetic process 78
            negative regulation of nitric oxide biosynthetic process 18
            positive regulation of nitric oxide biosynthetic process 43
            regulation of nitric oxide biosynthetic process + 67
paths to the root