Insr (insulin receptor) - Rat Genome Database

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Gene: Insr (insulin receptor) Chinchilla lanigera
Analyze
Symbol: Insr
Name: insulin receptor
RGD ID: 8865081
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase binding (ortholog); amyloid-beta binding (ortholog); ATP binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); activation of protein kinase B activity (ortholog); adrenal gland development (ortholog); PARTICIPATES IN altered insulin signaling pathway; altered leptin system pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; ASSOCIATED WITH AIDS Dementia Complex (ortholog); Alzheimer's disease (ortholog); breast cancer (ortholog); FOUND IN caveola (ortholog); cell body (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,867,400 - 2,009,149 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,867,400 - 2,011,845 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
activation of protein kinase B activity  (ISO)
adrenal gland development  (ISO)
alternative mRNA splicing, via spliceosome  (ISO)
amyloid-beta clearance  (ISO)
animal organ morphogenesis  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cerebellum development  (ISO)
dendritic spine maintenance  (ISO)
embryonic liver development  (ISO)
epidermis development  (ISO)
exocrine pancreas development  (ISO)
fat cell differentiation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (ISO)
heart morphogenesis  (ISO)
hippocampus development  (ISO)
insulin receptor signaling pathway  (ISO)
liver development  (ISO)
liver regeneration  (ISO)
male gonad development  (ISO)
male sex determination  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of transporter activity  (ISO)
neuron projection maintenance  (ISO)
obsolete activation of MAPK activity  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of meiotic cell cycle  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex disassembly  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of respiratory burst  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of embryonic development  (ISO)
regulation of female gonad development  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of hydrogen peroxide metabolic process  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to resveratrol  (ISO)
response to starvation  (ISO)
response to testosterone  (ISO)
response to tumor necrosis factor  (ISO)
response to vanadate(3-)  (ISO)
response to vitamin D  (ISO)
transformation of host cell by virus  (ISO)

References


Genomics

Comparative Map Data
Insr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,867,400 - 2,009,149 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,867,400 - 2,011,845 (+)NCBIChiLan1.0ChiLan1.0
INSR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl197,112,255 - 7,294,414 (-)EnsemblGRCh38hg38GRCh38
GRCh38197,112,257 - 7,294,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,112,276 - 7,294,425 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,063,266 - 7,245,011 (-)NCBINCBI36hg18NCBI36
Build 34197,067,637 - 7,245,011NCBI
Celera197,049,684 - 7,205,258 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef196,846,024 - 7,028,322 (-)NCBIHuRef
CHM1_1197,111,894 - 7,294,726 (-)NCBICHM1_1
Insr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,200,922 - 3,329,649 (-)NCBIGRCm39mm39
GRCm39 Ensembl83,172,061 - 3,329,617 (-)Ensembl
GRCm3883,150,922 - 3,279,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,122,061 - 3,279,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv3783,150,922 - 3,279,617 (-)NCBIGRCm37mm9NCBIm37
MGSCv3683,155,669 - 3,279,176 (-)NCBImm8
Celera83,375,321 - 3,505,728 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.82NCBI
Insr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2121,193,193 - 1,330,976 (-)NCBI
Rnor_6.0 Ensembl121,680,957 - 1,816,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0121,682,527 - 1,816,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0123,848,670 - 3,989,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,934,967 - 3,087,691 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1122,934,966 - 3,087,691 (+)NCBI
Celera123,053,590 - 3,185,991 (-)NCBICelera
Cytogenetic Map12p12NCBI
INSR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1197,255,444 - 7,411,916 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,260,246 - 7,414,889 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0196,393,407 - 6,578,234 (-)NCBIMhudiblu_PPA_v0panPan3
INSR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,017,261 - 52,136,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,021,887 - 52,136,046 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2051,822,227 - 51,957,301 (-)NCBI
ROS_Cfam_1.02052,547,342 - 52,682,557 (-)NCBI
UMICH_Zoey_3.12051,751,620 - 51,886,677 (-)NCBI
UNSW_CanFamBas_1.02052,194,853 - 52,330,054 (-)NCBI
UU_Cfam_GSD_1.02052,425,027 - 52,560,283 (-)NCBI
Insr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,335,383 - 213,489,477 (+)NCBI
SpeTri2.0NW_0049365884,345,306 - 4,453,380 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,797,204 - 71,936,139 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,797,209 - 71,939,923 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,388,108 - 72,420,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q11-q21NCBI
INSR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,625,951 - 6,803,610 (-)NCBI
ChlSab1.1 Ensembl66,630,777 - 6,803,592 (-)Ensembl
Vero_WHO_p1.0NW_0236660811,077,953 - 1,266,880 (+)NCBI
Insr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624828345,135 - 485,856 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000003757   ⟹   ENSCLAP00000003681
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555631,867,400 - 2,009,149 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000003758   ⟹   ENSCLAP00000003682
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555631,867,400 - 2,009,149 (+)Ensembl
RefSeq Acc Id: XM_013509165   ⟹   XP_013364619
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555631,867,400 - 2,011,845 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013364619 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013364619   ⟸   XM_013509165
- Sequence:
RefSeq Acc Id: ENSCLAP00000003681   ⟸   ENSCLAT00000003757
RefSeq Acc Id: ENSCLAP00000003682   ⟸   ENSCLAT00000003758


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002624 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000003681 ENTREZGENE
Ensembl Transcript ENSCLAT00000003757 ENTREZGENE
NCBI Gene Insr ENTREZGENE