Tlr2 (toll like receptor 2) - Rat Genome Database

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Gene: Tlr2 (toll like receptor 2) Chinchilla lanigera
Symbol: Tlr2
Name: toll like receptor 2
RGD ID: 8784137
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); diacyl lipopeptide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell activation (ortholog); cell surface pattern recognition receptor signaling pathway (ortholog); cellular response to bacterial lipopeptide (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acne (ortholog); acute kidney failure (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: toll-like receptor 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554718,014,910 - 8,017,258 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,011,710 - 8,019,063 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acne  (ISO)
acute kidney failure  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
alveolar echinococcosis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
Bacterial Eye Infections  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Abscess  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
clonorchiasis  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
diffuse scleroderma  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Eosinophilia  (ISO)
eumycotic mycetoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
eye disease  (ISO)
Fever  (ISO)
Fungal Eye Infections  (ISO)
gastroesophageal reflux disease  (ISO)
glomerulonephritis  (ISO)
Gram-Positive Bacterial Infections  (ISO)
Hearing Loss  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
ileitis  (ISO)
Inflammation  (ISO)
invasive aspergillosis  (ISO)
keratitis  (ISO)
keratoconjunctivitis  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
mastoiditis  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Meningitis, Escherichia Coli  (ISO)
meningococcal meningitis  (ISO)
mite infestation  (ISO)
molluscum contagiosum  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive jaundice  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Pain  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Plaque, Atherosclerotic  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
seborrheic dermatitis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
sinusitis  (ISO)
skin papilloma  (ISO)
Staphylococcal Infections  (ISO)
Streptococcal Infections  (ISO)
suppurative otitis media  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell activation  (ISO)
cell surface pattern recognition receptor signaling pathway  (ISO)
cellular response to bacterial lipopeptide  (ISO)
cellular response to diacyl bacterial lipopeptide  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to peptidoglycan  (ISO)
cellular response to triacyl bacterial lipopeptide  (ISO)
central nervous system myelin formation  (ISO)
defense response  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to virus  (ISO)
detection of diacyl bacterial lipopeptide  (ISO)
detection of triacyl bacterial lipopeptide  (ISO)
I-kappaB phosphorylation  (ISO)
inflammatory response  (ISO)
learning  (ISO)
leukotriene metabolic process  (ISO)
microglia development  (ISO)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of synapse assembly  (ISO)
nitric oxide metabolic process  (ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
positive regulation of xenophagy  (ISO)
regulation of dendritic cell cytokine production  (ISO)
response to bacterial lipoprotein  (ISO)
response to bacterium  (ISO)
response to fatty acid  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to molecule of fungal origin  (ISO)
response to peptidoglycan  (ISO)
response to progesterone  (ISO)
response to toxic substance  (ISO)
toll-like receptor signaling pathway  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554718,014,910 - 8,017,258 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,011,710 - 8,019,063 (+)NCBIChiLan1.0ChiLan1.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl4153,684,070 - 153,706,260 (+)EnsemblGRCh38hg38GRCh38
GRCh384153,684,080 - 153,710,643 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374154,605,432 - 154,627,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,824,891 - 154,846,693 (+)NCBINCBI36hg18NCBI36
Build 344154,966,670 - 154,984,135NCBI
Celera4151,929,928 - 151,951,730 (+)NCBI
Cytogenetic Map4q31.3NCBI
HuRef4150,336,457 - 150,358,268 (+)NCBIHuRef
CHM1_14154,583,811 - 154,605,614 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39383,743,579 - 83,749,045 (-)NCBIGRCm39mm39
GRCm39 Ensembl383,743,579 - 83,749,074 (-)Ensembl
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBImm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.14157,848,058 - 157,870,324 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,866,977 - 157,869,331 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04146,024,653 - 146,091,388 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11551,454,557 - 51,465,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,454,695 - 51,465,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,808,717 - 51,811,083 (+)NCBI
ROS_Cfam_1.01552,140,775 - 52,151,566 (+)NCBI
UMICH_Zoey_3.11551,404,786 - 51,407,152 (+)NCBI
UNSW_CanFamBas_1.01551,510,608 - 51,512,974 (+)NCBI
UU_Cfam_GSD_1.01551,821,784 - 51,824,151 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530139,016,995 - 39,024,812 (-)NCBI
SpeTri2.0NW_004936576522,234 - 531,660 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl875,411,991 - 75,446,850 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,416,257 - 75,428,370 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,823,867 - 79,834,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.17100,239,533 - 100,565,955 (+)NCBI
ChlSab1.1 Ensembl7100,258,441 - 100,260,795 (+)Ensembl
Vero_WHO_p1.0NW_02366603779,891,761 - 79,956,832 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248584,931,820 - 4,984,175 (+)NCBI



Reference Sequences
RefSeq Acc Id: ENSCLAT00000025795   ⟹   ENSCLAP00000025533
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554718,014,910 - 8,017,258 (+)Ensembl
RefSeq Acc Id: XM_005400927   ⟹   XP_005400984
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554718,011,710 - 8,019,063 (+)NCBI
RefSeq Acc Id: XM_013522906   ⟹   XP_013378360
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554718,011,901 - 8,019,063 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005400984 (Get FASTA)   NCBI Sequence Viewer  
  XP_013378360 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005400984   ⟸   XM_005400927
- Sequence:
RefSeq Acc Id: XP_013378360   ⟸   XM_013522906
- Sequence:
RefSeq Acc Id: ENSCLAP00000025533   ⟸   ENSCLAT00000025795

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017621 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000025533 ENTREZGENE
Ensembl Transcript ENSCLAT00000025795 ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tlr2  toll like receptor 2    toll-like receptor 2  Symbol and/or name change 5135510 APPROVED