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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of nitric oxide biosynthetic process
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Accession:GO:0045428 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
Synonyms:exact_synonym: regulation of nitric oxide anabolism;   regulation of nitric oxide biosynthesis;   regulation of nitric oxide formation;   regulation of nitric oxide synthesis



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regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 IEP RGD PMID:11829529 RGD:634667 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Cd47 Cd47 molecule involved_in ISO (MGI:6201986|PMID:16055727) RGD PMID:16055727 MGI:6201986 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in ISO UniProtKB:P05067 (MGI:6162390|PMID:23499256) RGD PMID:23499256 MGI:6162390 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator NAS RGD PMID:8702680 RGD:728623 NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080
JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO MGI:2386329|MGI:2389580 (MGI:5433272|PMID:21677284) RGD PMID:21677284 MGI:5433272 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Jak2 Janus kinase 2 involved_in IGI PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein involved_in TAS PMID:20431962 DFLAT PMID:20431962 RGD:8553554 NCBI chr13:82,549,786...82,820,949
Ensembl chr13:82,530,577...82,820,949
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISO (MGI:3810237|PMID:17698736) RGD PMID:17698736 MGI:3810237 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in IGI PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Sirpa signal-regulatory protein alpha involved_in IMP PMID:16055727 ARUK-UCL PMID:16055727 RGD:13792550 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098
JBrowse link
negative regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180086 (MGI:1930064|PMID:11168643)
Ensembl
RGD
PMID:11168643 GO_REF:0000107 MGI:1930064 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:11591728), (PMID:19278978) RGD PMID:11591728 PMID:19278978 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
G Cav1 caveolin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180364 (MGI:2450774|PMID:12388077)
Ensembl
RGD
PMID:12388077 GO_REF:0000107 MGI:2450774 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cd34 CD34 molecule involved_in ISO
ISS
(PMID:17505307)
GO_REF:0000024
RGD
UniProt
PMID:17505307 GO_REF:0000024 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Dynll1 dynein light chain LC8-type 1 acts_upstream_of_or_within IDA PMID:8864115 MGI PMID:8864115 RGD:633683 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G Epor erythropoietin receptor IMP RGD PMID:10489101 RGD:11041656 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:9519713 RGD:2303775 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086
JBrowse link
G Gla galactosidase, alpha involved_in ISO (MGI:3624267|PMID:15668341) RGD PMID:15668341 MGI:3624267 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664
JBrowse link
G Il10 interleukin 10 IDA RGD PMID:17017555 RGD:1598631 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il4 interleukin 4 IDA RGD PMID:18182309 RGD:2317291 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Khsrp KH-type splicing regulatory protein involved_in ISS
ISO
GO_REF:0000024
(PMID:16126846)
UniProt
RGD
PMID:16126846 GO_REF:0000024 NCBI chr 9:1,862,555...1,872,301
Ensembl chr 9:1,862,899...1,872,451
JBrowse link
G Oprm1 opioid receptor, mu 1 involved_in ISO
ISS
(PMID:20525224)
GO_REF:0000024
RGD
UniProt
PMID:20525224 GO_REF:0000024 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgis prostaglandin I2 synthase involved_in ISO
ISS
(PMID:20159982)
GO_REF:0000024
RGD
UniProt
PMID:20159982 GO_REF:0000024 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Rgn regucalcin IMP RGD PMID:12686401 RGD:9590175 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:6271078|PMID:29353861)
(PMID:29353861)
Ensembl
RGD
PMID:29353861 GO_REF:0000107 MGI:6271078 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Sirpa signal-regulatory protein alpha involved_in IEA
ISO
GO_REF:0000107
(MGI:3760575|PMID:17954568)
Ensembl
RGD
PMID:17954568 GO_REF:0000107 MGI:3760575 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098
JBrowse link
G Tspo translocator protein IDA RGD PMID:14678758 RGD:2317158 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Wdr35 WD repeat domain 35 IDA RGD PMID:18671723 RGD:11553926 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISO
ISS
(PMID:18178554)
(MGI:5142149|PMID:21616078)
GO_REF:0000024
RGD
UniProt
PMID:18178554 PMID:21616078 GO_REF:0000024 MGI:5142149 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
positive regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:17616753 RGD:8548892 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 involved_in IBA
ISO
PMID:21873635
(PMID:20018850)
RGD PMID:20018850 PMID:21873635 RGD:13792537 NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
JBrowse link
G Aif1 allograft inflammatory factor 1 IDA
IMP
RGD PMID:16157606 PMID:16157606 RGD:2313017, RGD:2313017 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:10376603) RGD PMID:10376603 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IMP RGD PMID:18335029 RGD:2313325 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:O00206|UniProtKB:P16671|UniProtKB:Q9Y2C9 (PMID:20037584) RGD PMID:20037584 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ass1 argininosuccinate synthase 1 involved_in ISO (PMID:21106532) RGD PMID:21106532 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Cd36 CD36 molecule involved_in ISO
IEA
UniProtKB:P05067:PRO_0000000092 (MGI:4438693|PMID:20037584)
GO_REF:0000107
RGD
Ensembl
PMID:20037584 GO_REF:0000107 MGI:4438693 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15857407)
Alzheimers_University_of_Toronto
Ensembl
RGD
PMID:15857407 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Crp C-reactive protein IDA RGD PMID:9767445 RGD:9586000 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 involved_in IMP
ISO
IBA
(MGI:5315329|PMID:21493890)
PMID:21873635
RGD PMID:21493890 PMID:12237779 PMID:21873635 MGI:5315329, RGD:727432, RGD:13792537 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:16973909 RGD:9685181 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Esr1 estrogen receptor 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:21937726)
UniProt
RGD
PMID:21937726 GO_REF:0000024 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Hrh1 histamine receptor H 1 IDA RGD PMID:12419527 RGD:727463 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3687888|PMID:12855682)
UniProt
RGD
PMID:12855682 GO_REF:0000024 MGI:3687888 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Icam1 intercellular adhesion molecule 1 IMP RGD PMID:9062344 RGD:1600239 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma involved_in
acts_upstream_of_or_within
ISO (PMID:8383325)
(MGI:1930064|PMID:11168643)
RGD PMID:8383325 PMID:11168643 MGI:1930064 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
(PMID:8383325)
Ensembl
RGD
PMID:8383325 GO_REF:0000107 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 IDA RGD PMID:15845578 RGD:2306941 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor involved_in ISO
IEA
(PMID:10747347)
GO_REF:0000107
RGD
Ensembl
PMID:10747347 GO_REF:0000107 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Itgb2 integrin subunit beta 2 IMP RGD PMID:9062344 RGD:1600239 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:12595539 RGD:1641934 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Klf2 Kruppel-like factor 2 acts_upstream_of ISO (PMID:21768538) RGD PMID:21768538 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Klf4 Kruppel like factor 4 involved_in ISO (PMID:22430140) RGD PMID:22430140 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klrk1 killer cell lectin like receptor K1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2450811|PMID:12645935)
Ensembl
RGD
PMID:12645935 GO_REF:0000107 MGI:2450811 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
JBrowse link
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like acts_upstream_of_or_within ISO MGI:3701255 (MGI:3700871|PMID:16476767) RGD PMID:16476767 MGI:3700871
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mir29b1 microRNA 29b-1 IMP RGD PMID:29374012 RGD:13702880 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IMP
ISO
IEA
PMID:25049354
(MGI:6201889|PMID:25049354)
GO_REF:0000107
RGD
Ensembl
PMID:25049354 PMID:25049354 GO_REF:0000107 MGI:6201889, RGD:13792525 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:19576187 RGD:10041012 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Oprm1 opioid receptor, mu 1 involved_in ISO (PMID:20214800) RGD PMID:20214800 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel involved_in ISO (PMID:19265036)
(MGI:5315687|PMID:19265036)
RGD PMID:19265036 MGI:5315687 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:21926342 RGD:10041069 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Ptx3 pentraxin 3 acts_upstream_of_or_within ISO (MGI:3037598|PMID:14726497) RGD PMID:14726497 MGI:3037598 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G RGD1565355 similar to fatty acid translocase/CD36 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Smad3 SMAD family member 3 involved_in ISO
IGI
(PMID:27038547) RGD PMID:27038547 PMID:27038547 RGD:11535100 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:14720208 RGD:10042970 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857480 (MGI:3577668|PMID:15637112) RGD PMID:15637112 MGI:3577668 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 acts_upstream_of_or_within ISO MGI:2679794 (MGI:2670551|PMID:12872135) RGD PMID:12872135 MGI:2670551 NCBI chr 9:1,102,559...1,115,573
Ensembl chr 9:1,102,366...1,123,147
JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of_or_within ISO MGI:2178675 (MGI:2178646|PMID:10549626), (MGI:3611539|PMID:16239543) RGD PMID:10549626 PMID:16239543 MGI:2178646 MGI:3611539 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P05067:PRO_0000000092 (MGI:4438693|PMID:20037584)
MGI:1860885 (MGI:2178646|PMID:10549626)
Ensembl
RGD
PMID:10549626 PMID:20037584 GO_REF:0000107 MGI:2178646 MGI:4438693 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr5 toll-like receptor 5 IDA RGD PMID:16973131 RGD:1643119 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO UniProtKB:O00206|UniProtKB:P05067:PRO_0000000092|UniProtKB:P16671 (MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:4438693 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:8383325) RGD PMID:8383325 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:16081483 RGD:2317115 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Ulbp1 UL16 binding protein 1 acts_upstream_of_or_within ISO (MGI:2450811|PMID:12645935) RGD PMID:12645935 MGI:2450811 NCBI chr 1:1,694,255...1,716,160 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    regulation of biological process 13033
      regulation of metabolic process 6931
        regulation of nitrogen compound metabolic process 5682
          regulation of nitric oxide metabolic process 81
            regulation of nitric oxide biosynthetic process 76
              negative regulation of nitric oxide biosynthetic process 20
              positive regulation of nitric oxide biosynthetic process 50
Path 2
Term Annotations click to browse term
  biological_process 19834
    metabolic process 12042
      nitrogen compound metabolic process 10185
        cellular nitrogen compound metabolic process 6716
          cellular nitrogen compound biosynthetic process 5039
            nitric oxide biosynthetic process 88
              regulation of nitric oxide biosynthetic process 76
                negative regulation of nitric oxide biosynthetic process 20
                positive regulation of nitric oxide biosynthetic process 50
paths to the root