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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 17 cell differentiation
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Accession:GO:0072539 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: T-helper 17 cell development


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T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993 		JBrowse link
G ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:99,659,509...99,711,241
Ensembl chr10:99,659,509...99,711,241 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022 		JBrowse link
G RORA RAR related orphan receptor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G RORC RAR related orphan receptor C involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:18792410) UniProt
MGI		 PMID:18792410 GO_REF:0000024 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588 		JBrowse link
G FOXP3 forkhead box P3 involved_in IMP (PMID:23169781) UniProt PMID:23169781 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18792410) TreeGrafter
MGI		 PMID:18792410 GO_REF:0000118 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G PF4 platelet factor 4 ISO RGD PMID:24986443 RGD:329901907 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:122,844,556...122,905,359
Ensembl chr 9:122,844,556...122,905,359 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23034280) Ensembl
MGI		 PMID:23034280 GO_REF:0000107 NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:37,474,580...37,484,377
Ensembl chr 1:37,474,580...37,484,377 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA
IDA
ISS		 (PMID:28065600) Ensembl
UniProt		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:74,532,258...74,555,702
Ensembl chr 2:74,532,258...74,555,690 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 1:173,039,202...173,050,941
Ensembl chr 1:173,039,202...173,050,941 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MALT1 MALT1 paracaspase involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:58,671,465...58,754,477
Ensembl chr18:58,671,465...58,754,477 		JBrowse link
G MIR21 microRNA 21 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR326 microRNA 326 acts_upstream_of_or_within ISO (PMID:19838199) MGI PMID:19838199 NCBI chr11:75,335,092...75,335,186
Ensembl chr11:75,335,092...75,335,186 		JBrowse link
G NFKBID NFKB inhibitor delta involved_in ISS UniProt GO_REF:0000024 NCBI chr19:35,887,952...35,902,303
Ensembl chr19:35,887,630...35,902,303 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in IEA
IDA		 (PMID:28262505) Ensembl
UniProt		 PMID:28262505 GO_REF:0000107 NCBI chr 6:32,968,594...32,981,505
Ensembl chr 6:32,968,594...32,981,505 		JBrowse link
G BRD4 bromodomain containing 4 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545 		JBrowse link
G EP300 E1A binding protein p300 involved_in IDA (PMID:28262505) UniProt PMID:28262505 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077 		JBrowse link
G IL12B interleukin 12B involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL12RB1 interleukin 12 receptor subunit beta 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr19:18,058,995...18,098,816
Ensembl chr19:18,058,995...18,098,944 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA
IBA
ISS		 Ensembl
GO_Central
BHF-UCL		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL23R interleukin 23 receptor involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in NAS (PMID:29234109) ComplexPortal PMID:29234109 NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,141 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit involved_in NAS (PMID:29234109) ComplexPortal PMID:29234109 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G MIR301A microRNA 301a acts_upstream_of_or_within ISO (PMID:22517757) MGI PMID:22517757 NCBI chr17:59,151,136...59,151,221
Ensembl chr17:59,151,136...59,151,221 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993 		JBrowse link
G IL6 interleukin 6 involved_in ISS (PMID:27893700) UniProt PMID:27893700 GO_REF:0000024 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6R interleukin 6 receptor involved_in IEA
ISS		 (PMID:27893700) Ensembl
UniProt		 PMID:27893700 GO_REF:0000107 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer involved_in ISS (PMID:27893700) UniProt PMID:27893700 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443 		JBrowse link
G JAK1 Janus kinase 1 involved_in TAS (PMID:27893700) UniProt PMID:27893700 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754 		JBrowse link
G LY9 lymphocyte antigen 9 involved_in IDA (PMID:22184727) UniProt PMID:22184727 NCBI chr 1:160,796,174...160,828,255
Ensembl chr 1:160,796,074...160,828,261 		JBrowse link
G OTUD5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chr  X:48,922,024...48,958,381
Ensembl chr  X:48,922,024...48,958,386 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in IDA
IBA
IEA		 (PMID:22184727) UniProt
GO_Central
TreeGrafter		 PMID:22184727 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:160,485,036...160,523,255
Ensembl chr 1:160,485,030...160,523,262 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 involved_in TAS (PMID:27893700) UniProt PMID:27893700 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19613
    immune system process 3224
      immune response 2288
        adaptive immune response 839
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 453
            T-helper 17 type immune response 60
              T-helper 17 cell differentiation 45
                T-helper 17 cell lineage commitment + 22
                negative regulation of T-helper 17 cell differentiation + 13
                positive regulation of T-helper 17 cell differentiation + 14
                regulation of T-helper 17 cell differentiation + 32
Path 2
Term Annotations click to browse term
  biological_process 19613
    developmental process 7605
      cellular developmental process 5172
        cell differentiation 5171
          cell development 3453
            hemopoiesis 1167
              leukocyte differentiation 749
                mononuclear cell differentiation 620
                  lymphocyte differentiation 513
                    T cell differentiation 365
                      T cell differentiation involved in immune response 98
                        alpha-beta T cell differentiation involved in immune response 90
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 89
                            T-helper cell differentiation 87
                              T-helper 17 cell differentiation 45
                                T-helper 17 cell lineage commitment + 22
                                negative regulation of T-helper 17 cell differentiation + 13
                                positive regulation of T-helper 17 cell differentiation + 14
                                regulation of T-helper 17 cell differentiation + 32
paths to the root