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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 17 cell lineage commitment
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Accession:GO:0072540 term browser browse the term
Definition:The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Synonyms:exact_synonym: T-helper 17 cell fate commitment;   Th17 cell lineage commitment;   Th17 fate commitment


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T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO		 GO_REF:0000024
(MGI:3851267|PMID:19578362), (MGI:5448096|PMID:22983707)		 UniProt
RGD		 PMID:19578362 PMID:22983707 GO_REF:0000024 MGI:3851267 MGI:5448096 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3692468|PMID:16990136), (MGI:6142555|PMID:27893700)
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:16990136 PMID:27893700 GO_REF:0000002 GO_REF:0000024 MGI:3692468 MGI:6142555 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6142555|PMID:27893700)		 UniProt
Ensembl
RGD		 PMID:27893700 GO_REF:0000024 GO_REF:0000107 MGI:6142555 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (MGI:5448096|PMID:22983707) RGD PMID:22983707 MGI:5448096 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (PMID:25470037) RGD PMID:25470037 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO
IBA		 (PMID:22184727)
GO_REF:0000033		 RGD
GO_Central		 PMID:22184727 GO_REF:0000033 NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5825383|PMID:28065600)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 MGI:5825383 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825383|PMID:28065600)
(PMID:28065600)		 RGD PMID:28065600 MGI:5825383 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28262505)
(MGI:6106706|PMID:28262505)		 UniProt
RGD		 PMID:28262505 GO_REF:0000024 MGI:6106706 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) RGD PMID:28262505 MGI:6106706 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IBA		 (MGI:3851279|PMID:19501566)
GO_REF:0000033		 RGD
GO_Central		 PMID:19501566 GO_REF:0000033 MGI:3851279 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    immune system process 3017
      T cell selection 58
        positive T cell selection 43
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 26
            CD4-positive, alpha-beta T cell lineage commitment 22
              T-helper cell lineage commitment 20
                T-helper 17 cell lineage commitment 16
                  negative regulation of T-helper 17 cell lineage commitment 3
                  positive regulation of T-helper 17 cell lineage commitment 5
                  regulation of T-helper 17 cell lineage commitment + 8
Path 2
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cellular developmental process 4768
        cell differentiation 4767
          cell development 3311
            hemopoiesis 1064
              leukocyte differentiation 676
                mononuclear cell differentiation 545
                  lymphocyte differentiation 448
                    T cell differentiation 324
                      T cell differentiation involved in immune response 89
                        alpha-beta T cell differentiation involved in immune response 81
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 80
                            T-helper cell differentiation 78
                              T-helper cell lineage commitment 20
                                T-helper 17 cell lineage commitment 16
                                  negative regulation of T-helper 17 cell lineage commitment 3
                                  positive regulation of T-helper 17 cell lineage commitment 5
                                  regulation of T-helper 17 cell lineage commitment + 8
paths to the root