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ONTOLOGY REPORT - ANNOTATIONS


Term:T-helper 17 type immune response
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Accession:GO:0072538 term browser browse the term
Definition:An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22.
Synonyms:exact_synonym: Th17 immune response



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T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il17ra interleukin 17 receptor A involved_in ISO (MGI:5920593|PMID:28561022) RGD PMID:28561022 MGI:5920593 NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:5920593|PMID:28561022) RGD PMID:28561022 MGI:5920593 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Phb1 prohibitin 1 involved_in ISO
ISS
(PMID:31899195)
GO_REF:0000024
RGD
UniProt
PMID:31899195 GO_REF:0000024 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (PMID:31899195) RGD PMID:31899195 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO (MGI:5920593|PMID:28561022) RGD PMID:28561022 MGI:5920593 NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667
JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:5634593 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3817792|PMID:18792410)
RGD PMID:18792410 PMID:21873635 MGI:3817792, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933
JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO
GO_REF:0000107
(MGI:5634593|PMID:25642768)
Ensembl
RGD
PMID:25642768 GO_REF:0000107 MGI:5634593 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3530739 (MGI:5450776|PMID:23034280) RGD PMID:23034280 MGI:5450776 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO
GO_REF:0000024
(MGI:6142401|PMID:25282160)
UniProt
RGD
PMID:25282160 GO_REF:0000024 MGI:6142401 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:5825383 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
JBrowse link
negative regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27ra interleukin 27 receptor subunit alpha involved_in ISO UniProtKB:P35951 (MGI:5581894|PMID:22927332) RGD PMID:22927332 MGI:5581894 NCBI chr19:24,109,698...24,121,977
Ensembl chr19:24,109,972...24,121,938
JBrowse link
G Smad7 SMAD family member 7 involved_in ISO (MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:5634593 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260
JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (MGI:4436838|PMID:19838199) RGD PMID:19838199 MGI:4436838 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123
JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447
JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO
PMID:21873635
(MGI:3851279|PMID:19501566)
RGD PMID:19501566 PMID:21873635 MGI:3851279, RGD:13792537 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
positive regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arid5a AT-rich interaction domain 5A involved_in ISO (MGI:5780752|PMID:27022145) RGD PMID:27022145 MGI:5780752 NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
JBrowse link
G Card9 caspase recruitment domain family, member 9 involved_in ISO (PMID:24231284), (PMID:29080677)
(MGI:5567862|PMID:24470469), (MGI:6445005|PMID:32358020)
RGD PMID:24231284 PMID:24470469 PMID:29080677 PMID:32358020 MGI:5567862 MGI:6445005 NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
JBrowse link
G Clec4a C-type lectin domain family 4, member A involved_in ISO (MGI:6445005|PMID:32358020) RGD PMID:32358020 MGI:6445005 NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
JBrowse link
G Clec6a-ps1 C-type lectin domain family 6, member A, pseudogene 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:156,539,408...156,559,032
Ensembl chr 4:156,539,408...156,558,605
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:16482511) RGD PMID:16482511 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (MGI:3851279|PMID:19501566)
(PMID:16482511)
RGD PMID:16482511 PMID:19501566 MGI:3851279 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Mir301a microRNA 301a acts_upstream_of_or_within ISO (MGI:5426073|PMID:22517757) RGD PMID:22517757 MGI:5426073 NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435
JBrowse link
G Nlrp10 NLR family, pyrin domain containing 10 involved_in ISO (MGI:5449483|PMID:23071280) RGD PMID:23071280 MGI:5449483 NCBI chr 1:162,922,806...162,930,363
Ensembl chr 1:162,922,806...162,930,363
JBrowse link
G Prkcq protein kinase C, theta involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3769226|PMID:16493044)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:16493044 GO_REF:0000024 GO_REF:0000107 MGI:3769226 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:3820359 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:3820359 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Mir301a microRNA 301a acts_upstream_of_or_within ISO (MGI:5426073|PMID:22517757) RGD PMID:22517757 MGI:5426073 NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435
JBrowse link
regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb2 Eph receptor B2 IDA RGD PMID:33722292 RGD:127285641 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:5621075 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573
JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
GO_REF:0000024
(MGI:4456325|PMID:20421391), (MGI:5004732|PMID:21572431)
UniProt
RGD
PMID:20421391 PMID:21572431 GO_REF:0000024 MGI:4456325 MGI:5004732 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051
JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in ISO (MGI:5461233|PMID:23241884) RGD PMID:23241884 MGI:5461233 NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447
JBrowse link
G Rora RAR-related orphan receptor A involved_in ISO (MGI:3772713|PMID:18164222) RGD PMID:18164222 MGI:3772713 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Rorc RAR-related orphan receptor C involved_in
acts_upstream_of_or_within
ISO (MGI:3692468|PMID:16990136), (MGI:3772713|PMID:18164222)
(MGI:3817792|PMID:18792410)
RGD PMID:16990136 PMID:18164222 PMID:18792410 MGI:3692468 MGI:3772713 MGI:3817792 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
GO_REF:0000024
(MGI:3851267|PMID:19578362), (MGI:5448096|PMID:22983707)
UniProt
RGD
PMID:19578362 PMID:22983707 GO_REF:0000024 MGI:3851267 MGI:5448096 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051
JBrowse link
G Il6 interleukin 6 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000002
(MGI:3692468|PMID:16990136), (MGI:6142555|PMID:27893700)
UniProt
InterPro
RGD
PMID:16990136 PMID:27893700 GO_REF:0000002 GO_REF:0000024 MGI:3692468 MGI:6142555 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6142555|PMID:27893700)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:27893700 GO_REF:0000024 GO_REF:0000107 MGI:6142555 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (MGI:5448096|PMID:22983707) RGD PMID:22983707 MGI:5448096 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:84,081,283...84,100,757
Ensembl chr13:84,079,458...84,100,823
JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:5621075 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573
JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO
IBA
(PMID:22184727)
PMID:21873635
RGD PMID:22184727 PMID:21873635 RGD:13792537 NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300
JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5825383|PMID:28065600)
UniProt
RGD
PMID:28065600 GO_REF:0000024 MGI:5825383 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    response to stimulus 10575
      immune response 1697
        adaptive immune response 428
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 342
            T-helper 17 type immune response 45
              T-helper 17 cell differentiation + 31
              negative regulation of T-helper 17 type immune response + 12
              positive regulation of T-helper 17 type immune response + 14
              regulation of T-helper 17 type immune response + 31
paths to the root