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Ontology Browser

Term:
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460)
Annotations: Rat: (342) Mouse: (471) Human: (418) Chinchilla: (242) Bonobo: (282) Dog: (291) Squirrel: (258) Pig: (297)
Parent Terms Term With Siblings Child Terms
adaptive immune effector response +  
adaptive immune memory response +   
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +   
An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains 
negative regulation of adaptive immune response +   
positive regulation of adaptive immune response +   
primary adaptive immune response +   
regulation of adaptive immune response +   
suppression by virus of host adaptive immune response +  

Synonyms
Definition Sources: GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831

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