Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:interstrand cross-link repair
go back to main search page
Accession:GO:0036297 term browser browse the term
Definition:Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
Synonyms:exact_synonym: ICL repair


show annotations for term's descendants           Sort by:
interstrand cross-link repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenps centromere protein S involved_in ISO (PMID:20347429) RGD PMID:20347429 NCBI chr 5:159,563,917...159,573,534 JBrowse link
G Cenpx centromere protein X involved_in ISO (PMID:20347429) RGD PMID:20347429 NCBI chr10:105,991,469...105,994,310 JBrowse link
G Dclre1a DNA cross-link repair 1A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:255,569,911...255,589,815
Ensembl chr 1:255,569,919...255,589,678 		JBrowse link
G Dclre1b DNA cross-link repair 1B involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:20479256)		 Ensembl
GO_Central
RGD		 PMID:20479256 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423 		JBrowse link
G Dclre1c DNA cross-link repair 1C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO (PMID:23637614) RGD PMID:23637614 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc6l2 ERCC excision repair 6 like 2 involved_in ISO
IBA		 (PMID:24507776)
GO_REF:0000033		 RGD
GO_Central		 PMID:24507776 GO_REF:0000033 NCBI chr17:1,076,486...1,311,281
Ensembl chr17:1,216,428...1,310,275 		JBrowse link
G Exo5 exonuclease 5 involved_in ISO
IBA		 (PMID:23095756)
GO_REF:0000033		 RGD
GO_Central		 PMID:23095756 GO_REF:0000033 NCBI chr 5:134,494,440...134,497,757
Ensembl chr 5:134,493,829...134,497,772 		JBrowse link
G Faap100 FA core complex associated protein 100 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:105,641,677...105,653,809
Ensembl chr10:105,639,414...105,653,494 		JBrowse link
G Faap20 FA core complex associated protein 20 involved_in ISO
ISS		 (PMID:22266823), (PMID:22396592), (PMID:22705371)
GO_REF:0000024		 RGD
UniProt		 PMID:22266823 PMID:22396592 PMID:22705371 GO_REF:0000024 NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333 		JBrowse link
G Faap24 FA core complex associated protein 24 involved_in ISO (PMID:20347429) RGD PMID:20347429 NCBI chr 1:88,051,523...88,057,997
Ensembl chr 1:88,051,911...88,057,989 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 involved_in ISO
IBA		 (PMID:25430771)
GO_REF:0000033		 RGD
GO_Central		 PMID:25430771 GO_REF:0000033 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
G Fanca FA complementation group A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527 		JBrowse link
G Fancb FA complementation group B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192 		JBrowse link
G Fancc FA complementation group C involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376 		JBrowse link
G Fancd2 FA complementation group D2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Fance FA complementation group E involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631 		JBrowse link
G Fancf FA complementation group F involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923 		JBrowse link
G Fancg FA complementation group G involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Fancl FA complementation group L involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255 		JBrowse link
G Fancm FA complementation group M involved_in ISO
IBA		 (PMID:20347429)
GO_REF:0000033		 RGD
GO_Central		 PMID:20347429 GO_REF:0000033 NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028 		JBrowse link
G Firrm FIGNL1 interacting regulator of recombination and mitosis involved_in ISO
ISS		 (PMID:37256941)
GO_REF:0000024		 RGD
UniProt		 PMID:37256941 GO_REF:0000024 NCBI chr13:76,301,914...76,345,842
Ensembl chr13:76,301,918...76,345,804 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
ISO		 GO_REF:0000024
(PMID:33321094), (PMID:36608669), (PMID:37519246), (PMID:37950866)		 UniProt
RGD		 PMID:33321094 PMID:36608669 PMID:37519246 PMID:37950866 GO_REF:0000024 NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616 		JBrowse link
G Hrob homologous recombination factor with OB-fold involved_in ISO
IEA
ISS		 (PMID:31467087)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:31467087 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,206,017...87,222,483
Ensembl chr10:87,206,049...87,222,483 		JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 involved_in ISO
IBA		 (PMID:26323318)
GO_REF:0000033		 RGD
GO_Central		 PMID:26323318 GO_REF:0000033 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229 		JBrowse link
G Poln DNA polymerase nu involved_in ISO (PMID:19908865), (PMID:19995904) RGD PMID:19908865 PMID:19995904 NCBI chr14:76,579,983...76,752,460
Ensembl chr14:76,580,546...76,752,463 		JBrowse link
G Rad51 RAD51 recombinase involved_in ISO (PMID:26253028) RGD PMID:26253028 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 involved_in ISO
IBA		 (PMID:26323318)
GO_REF:0000033		 RGD
GO_Central		 PMID:26323318 GO_REF:0000033 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rad51d RAD51 paralog D acts_upstream_of_or_within ISO MGI:2386281 (PMID:15781618) RGD PMID:15781618 NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:28575657), (PMID:28575658), (PMID:33321094) RGD PMID:28575657 PMID:28575658 PMID:33321094 NCBI chr19:39,235,883...39,268,479
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Sprtn SprT-like N-terminal domain involved_in ISO
IEA		 (PMID:36608669)
GO_REF:0000107		 RGD
Ensembl		 PMID:36608669 GO_REF:0000107 NCBI chr19:52,857,612...52,864,864
Ensembl chr19:52,857,866...52,864,864 		JBrowse link
G Vcp valosin-containing protein involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:26323318) RGD PMID:26323318 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
nucleotide-excision repair involved in interstrand cross-link repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO
IBA		 (PMID:32034146)
GO_REF:0000033		 RGD
GO_Central		 PMID:32034146 GO_REF:0000033 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
recombinational interstrand cross-link repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor involved_in ISO (PMID:23401855) RGD PMID:23401855 NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008 		JBrowse link
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO
IEA		 (PMID:23401855)
GO_REF:0000107		 RGD
Ensembl		 PMID:23401855 GO_REF:0000107 NCBI chr20:32,818,219...32,929,577
Ensembl chr20:32,844,951...32,929,600 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    response to stimulus 10793
      response to stress 4260
        cellular response to stress 2017
          DNA damage response 868
            DNA repair 554
              interstrand cross-link repair 37
                non-recombinational interstrand cross-link repair 0
                nucleotide-excision repair involved in interstrand cross-link repair 2
                recombinational interstrand cross-link repair 2
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        primary metabolic process 10579
          nucleobase-containing compound metabolic process 5792
            nucleic acid metabolic process 5183
              DNA metabolic process 967
                DNA repair 554
                  interstrand cross-link repair 37
                    non-recombinational interstrand cross-link repair 0
                    nucleotide-excision repair involved in interstrand cross-link repair 2
                    recombinational interstrand cross-link repair 2
paths to the root